Dear Future Centenarian,

You almost certainly have at least one. And the temporary comfort it gives you could very well cost you your life.

Almost all of us are unknowingly addicts. When we use that A word, it generally conjures up images of someone struggling with hard to shake drug, alcohol, or tobacco habits.

But most addictions ar­­e much more subtle… and seemingly harmless.

First, exactly what is an addiction? All addictions seem to boil down to one thing – losing your ability to abstain.

That’s acutely obvious with alcohol addiction for example.

Sure, alcoholism is a serious issue, leading to ruining personal and professional lives. And of course it could be a serious life shortener. On the other hand, we all know of functional alcoholics who manage successful careers. But the rest of their lives can be disastrous.

Let’s look at seemingly innocuous “habits” that are in fact addictions which can ruin lives and careers, robbing us of our chances to achieve the dreams, hopes and aspirations that are usually dividing lines between happiness and unhappiness.

Between success and failure.

And often between wellness and death.

These addictions can be anything you surrender to:

Sleeping in. Sugar. Second helpings. Passively watching TV. Skipping workouts. Negative thinking. Physical laziness. Mental laziness. Living in the past. Accepting things at face value. Reluctance to say “no.” Going with the flow.

We can go on an on with this exercise. Sometimes addictions are things that seem virtuous such as working unreasonably long hours… but while ignoring your family… also known as “workaholism.”

In my analysis, all addictions contribute to chronic stress. (And chronic stress kills.)

That’s just one way addictions shorten your life… while extending your periods of sickness and suffering.

I know I keep hammering away at how important it is to manage your lifestyle with healthy longevity as your target. I used to annoy some friends who lived for instant gratification and almost universally told me: “You have to die from something.”

My usual retort was that their habits typically lead to years of sickness before killing them. I gave up on trying to convince them that reversing their course could lead to open ended healthy lifespans.

Now, I don’t bother broaching the subject with them. In fact, I rarely speak with most of them at all anymore. We drifted apart, since I get satisfaction from relationships with people like you who place a high value on life, wellness, and longevity.

That’s energizing. Trying to convince anyone to do something that simply does not resonate with them drains your energy… and chews up your time.

So it’s YOUR addictions I want to address. Mainly the life-shortening ones like poor diet choices, lack of exercise, stress, and more. I wrote about each in detail in Smart, Strong and Sexy at 100.

Leading radical life extension authorities calculate we could reach the age reversal tipping point in nine years or so.

That doesn’t mean they agree you will be rejuvenated by then. It does mean you could essentially stop deteriorating from aging by 2030 if you take the right steps… starting TODAY.

Then you could be able to comfortably live the good life until rejuvenating technologies can dramatically turn back your aging clock.

Next week, I will show you how and why this could be possible.

Don’t expect a free lunch though. You will need to work to survive those sneaky addictions and trade short term gratification leading to DEATH for long term satisfaction and LIFE.

More Life,
David Kekich



Weekly News

Senescent Microglia are Present in Greater Numbers in the Brains of Patients with Neurodegenerative Conditions

Accumulation of lingering senescent cells is an important mechanism of aging, as these errant cells secrete a potent mix of molecules that spurs chronic inflammation and degrades nearby tissue structure and function.

Evidence has emerged for the presence of senescent supporting cells in the brain, such as microglia and astrocytes, to contribute to many different neurodegenerative diseases.

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An Interview with Ronjon Nag, Investor in the Longevity Industry

Ronjon Nag is an academic turned inventor turned entrepreneur turned investor in the communications and software industries, and now of late the longevity industry, a career path shared with a growing number of his peers in the Bay Area investment community.

Alongside his principals Anastasiya Giarletta and Artem Trotsyuk, Ronjon Nag runs R42, a fund that grew out of his angel investing experience and successes. As is the case for near all of those who arrived comparatively early to the advent of this new industry, the R42 Group principals have a strong personal interest in health and longevity.

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The longevity industry started up in earnest over the past five years or so, as early successes in aging research moved out of the labs and into biotech companies. In parallel, a growing number of technology investors have developed an interest in this field, expanding their portfolios to include biotechnology startups focused on aging. This is the next step in an ongoing process of support and interest: the application of the life sciences to the slowing and reversal of aging has long been an attraction to the successful and the influential of the Bay Area. It isn’t an accident that the SENS Research Foundation was located there, for example, and nor is it an accident that much of the charitable funding that has supported rejuvenation research programs over the past decade or more was provided by technology industry philanthropists.

A Profile of Buck Institute Startup Company Gerostate Alpha

A sizable fraction of the startup biotech companies in the small but growing longevity industry are essentially screening programs, in that they are developing various improvements on the standard approaches to screening small molecule databases in search of drugs that affect mechanisms relevant to aging.

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The Potential for Senolytics and Other Senotherapies to Improve Outcomes in Cancer Therapies

Cellular senescence is a double-edged sword in the matter of cancer. The state of senescence is a growth arrest coupled with pressure to self-destruct and a call to the immune system to destroy the senescent cell.

As such it serves as a first line of defense against cancer. Most cancer treatments force large numbers of cancerous cells into senescence, in addition to causing outright cell death, shutting down their ability to replicate. Unfortunately, the presence of too many senescent cells is harmful in and of itself, as their signaling produces chronic inflammation, disrupts tissue function throughout the body, and makes the environment more hospitable for cancer growth.

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Profiles of Two Senolytics Companies with Quite Different Approaches

The two senolytics companies profiled here employ quite different approaches to the selective destruction of senescent cells, and indeed also to the business side of the equation – which age-related conditions to tackle first, whether to build a therapy or a platform for therapies, and so forth.

These are two representative companies of a much larger number of groups working in this part of the field. It isn’t just biotech startups.

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Aging is Contagious within the Body

In the midst of a discussion regarding the limitations of life span studies, in that the use of death as an endpoint fails to capture all of the variances in health due to aging, the authors of this paper offer up the thought that aging is contagious within the body. Declines in one cell spread to another, directly or indirectly.

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Reduced Capillary Density in the Retina Indicative of the Progression of Neurodegeneration

Capillary networks are very dense, hundreds of capillaries passing through any given square millimeter of tissue. This network of microvessels is necessary to supply tissues with oxygen and nutrients. Unfortunately it declines in density with age, for reasons that are not well understood in detail.

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Visual Decline Correlates with Severity of Parkinson’s Disease

Researchers here note that in many people visual decline precedes the more evident worsening of Parkinson’s disease as it progresses.

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Reviewing the Epigenetics of Aging

Epigenetic mechanisms regulate the pace of production of specific proteins in a cell. Feedback loops link the activities of proteins produced, input from the surrounding cell environment, and epigenetic alterations that change further production of proteins.

Epigenetic control of protein production shifts constantly in response to circumstances, but many changes are characteristic of aging and the aged tissue environment.

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More Evidence for Senescent Cell Clearance as a Treatment for Neurodegenerative Conditions

Senescent cells accumulate in the brain with age, and these cells generate chronic inflammation in brain tissue. Neurodegenerative conditions such as Alzheimer’s disease are known to prominently involve inflammation in the progression of pathology.

At least one senolytic treatment, the combination of dasatinib and quercetin, can pass the blood-brain barrier to destroy senescent cells in the brain, and has been shown to reduce inflammation and reverse tau pathology in mouse models of Alzheimer’s disease.

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EP2 Knockdown in Macrophages Reduces Inflammation and Restores Cognitive Function in an Alzheimer’s Mouse Model

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Chronic Inflammation and Macrophage Dysfunction in Aging

Chronic inflammation is of great importance in degenerative aging. Unresolved inflammation that lingers for the long term disrupts tissue function and accelerates the onset and progression of many age-related conditions.

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CDC42 Inhibition via CASIN as a Possible Approach to Rejuvenation of Hematopoietic Stem Cell Function

CDC42 inhibition looks promising as a way to rejuvenate immune function via reversing the age-related disruption of hematopoiesis in bone marrow.

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Improving Synthetic Bone Materials to Heal Injuries

Packing injured bone with synthetic bone material can speed regeneration, allowing even severe injuries involving missing bone or multiple fractures to resolve. Here researchers report on improvements to this class of approach, coercing the behavior of natural processes of bone growth and resorption to be more amenable to the regeneration that is desired.

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One Cannot be “Fat But Healthy”

Extensive human evidence strongly supports the conjecture that excess fat tissue is simply harmful. That harm cannot be evaded by exercise: one cannot be “fat but healthy”.

Visceral fat packed around the abdominal organs generates chronic inflammation, a raised burden of senescent cells, and all sorts of other issues. It pushes fat into the organs themselves; in the case of the pancreas that excess fat is the primary cause of type 2 diabetes.

In the liver, it leads to fatty liver disease. Even modest amounts of excess fat tissue raise mortality rates and shorten life expectancy.

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