Dear Future Centenarian,
“The most expensive information in the world is bad information.”
My cousin Rich told me, that when he was in high school in the ‘70s, one of his science teachers told the class not to believe 90% of the news.
And here we thought ‘fake news” was a new phenomenon.
The more time, money, and thinking you invest in your education, the quicker you will attain wisdom, esteem, happiness and success.
That doesn’t mean regurgitating what you’re told, read or view. It does mean learning to THINK for yourself… to analyze, to dissect arguments and look at them from all angles before reaching conclusions.
It also means analyzing both sides of controversial issues, even if, and especially if, you strongly disagree with one side.
Who knows, maybe you’ll discover you have been wrong most of your life on some issues important to you.
That doesn’t mean you will necessarily have to spend a fortune on “education” on the world’s most expensive universities.
In fact, you will get a leg up on most of the world by investing $25 on a book called “The Daily Stoic” and invest just 20 minutes a day for a year. Four minutes on reading just one page a day and 16 minutes thinking deeply about what you read and what it means to you.
You will now be on the path to understanding how the world works and will start to learn to shield yourself from misinformation. You will learn the art of living in one short year and will be positioned to get the most out of educational courses, lectures, and videos moving forward.
You will start to acquire the skill of intellectual leverage and save years in squeezing the meat out of your education while casting aside the majority of information which is superfluous and/or wrong.
What I’ve found is “expensive” is relative.
There are people who simply don’t want to pay for anything, or they aren’t willing to invest in themselves.
Many people in fact. Actually most.
That said, I put a lot of information in my newsletters, and it doesn’t cost anything…
But think about the advice, suggestions, or information you followed (or were given) at some point that led to a bad result.
Now, think about some of the BEST advice, suggestions, or information you got.
Think about some of the best things you bought having the highest return and most use in any area of your life; your health, relationships, finances, and/or more.
If you set your mindset to look for information that is Useful and Valuable – not ‘cheap’ – it can Transform your Health, Longevity, and Life.
One example is RAADfest. It’s not free, but you get cutting edge information from some of the world’s experts on health and longevity.
It’s also unbelievably AFFORDABLE.
Even though they are carefully screened, does that mean SPEAKERS are all correct? Far from it. Do you know anyone who is right 100% of the time? I don’t. But now I’m better equipped to dig in, internalize the info and come to my own conclusions.
By applying critical thinking, you will get a bonus… increased comprehension.
When it comes to your health, question your doctors and conventional “wisdom.” If you search hard enough, you’ll find doctors and health advisors who are as dedicated, independent, and diligent in their thinking skills as I recommend you become.
Targeting Neuroinflammation in Alzheimer’s Disease
As noted by the authors of today’s open access review paper, Alzheimer’s disease is just as strongly characterized by chronic inflammation in brain tissue as it is by the presence of aggregates of amyloid-? and phosphorylated tau.
More modern views of Alzheimer’s disease etiology place more emphasis on chronic inflammation as a cause of pathology, either wrapping it into the amyloid cascade hypothesis, or replacing amyloid-? with inflammatory processes in the progression of the foundational, earlier stage of the condition.
Looking Forward to the Longevity Industry in 2021
Having written retrospectives for 2020, longevity industry observers are now looking forward to what we might expect in 2021. This survey of companies and projects in the longevity industry is unbiased from the point of view of whether or not the treatments under development are expected to have a sizable effect on human aging.
Can they slow aging or actually reverse aging meaningfully? It is more focused on progress on startups, business matters, and potential for profit.
KAT7 Inhibition via Gene Therapy Reduces Cellular Senescence in the Liver and Extends Life in Mice
Since the confirmation of cellular senescence as an important contributing cause of aging, a great many research initiatives have focused on the biochemistry of senescent cells, in search of new approaches to rejuvenation therapies.
A common strategy in the life sciences is to deactivate genes one by one and observe the results, in search of suitable regulators to change cell behavior. In today’s open access paper, researchers report on the results of such a screen of gene functions, identifying KAT7 as a gene important in the regulation of cellular senescence in at least the liver.
The 2020 Year End Fundraiser Brought in More than 2 Million for the SENS Research Foundation
The SENS Research Foundation represents the best of charitable organizations working on the treatment of aging as a medical condition.
It is well run, focuses on approaches capable of rejuvenation rather than merely modestly slowing aging, devotes funds and attention towards those projects in rejuvenation research that most need support in order to advance, and has a great track record when it comes to helping development programs to make the leap from academic laboratories to commercial development in startup biotech companies.
A Few More Mammalian Species Found to Exhibit Amyloid-? and Tau Pathology
The primary challenge in Alzheimer’s disease research has long been that short-lived laboratory species do not naturally exhibit any of the features of the condition.
Thus all mouse models of the condition are highly artificial genetic constructs, and potential treatments and relevant mechanisms in these models have a high chance of being irrelevant to Alzheimer’s disease as it exists in humans.
Suggesting Gum Disease Worsens the Progression of Other Conditions via Oxidative Stress Rather than Inflammation
Periodontitis, gum disease, produces chronic inflammation that is thought to worsen the progression of conditions such as cardiovascular disease and dementia, through the size of the effect is debated.
Certainly there are good reasons to believe that more chronic inflammatory signaling is worse than less chronic inflammatory signaling. Researchers here suggest that the observed relationship between periodontitis and progression of chronic kidney disease is mediated by excessive production of oxidative molecules rather than by inflammation.
Effects of Calorie Restriction on Cognitive Decline
The practice of calorie restriction slows aging and extends healthy life, quite dramatically so in short-lived species, and far more modestly in long-lived species.
All of the mechanisms of aging, the forms of damage that accumulate in old tissues and the outcomes of that damage, are affected. Some are affected more than others, however. So it is possible to see some aspects of aging that are less robustly responsive to calorie restriction, such as loss of cognitive function, as noted here.
Immunosenescence in Alzheimer’s Disease
Researchers here catalog the various mechanisms known to be involved in the development of Alzheimer’s disease that occur as a result of the aging of the immune system.
The immune system becomes less effective with age, but also constantly overactive. It generates constant and unresolved inflammatory signaling that damages tissue structure and disrupts tissue function. All of the common age-related conditions are accelerated and worsened by the chronic inflammation resulting from the age-damaged immune system.
Thoughts on the Road to Greater Human Longevity
I recently noticed this scientific commentary, published in a journal not specifically focused on aging. The author is far from the only person to have noticed that priorities in medical research and development do not seem to match up with the major causes of death all that well. I
t can’t hurt to keep on pointing out that research into the most harmful biological processes in the world, meaning the mechanisms that cause aging, is very poorly funded and investigated in comparison to the vast and ongoing toll of death that results. Until aging is defeated, more funding for research into rejuvenation therapies will continue to be the most cost-effective way to improve the human condition.
Predicting Alzheimer’s Disease via Detection of Misfolded Amyloid-? in a Blood Sample
The research community is making progress towards forms of low cost testing for Alzheimer’s disease risk. At present, the well-established tests are invasive or expensive.
The very early stages of Alzheimer’s disease, in which symptoms are mild or absent, are characterized by increasing levels of amyloid-? in the brain. However, amyloid-? in the brain is in a state of dynamic equilibrium with amyloid-? in the bloodstream, and in principle a suitable sensitive test can use a blood sample to assess the relevant aspects of amyloid-? burden.
It takes years to validate predictions of Alzheimer’s risk of course, and here researchers report on a lengthy but successful validation of one particular blood sample assay.
Targeting TGF? to Treat Fibrotic Disease
TGF? is an important component of the inflammatory signaling of senescent cells, and cellular senescence is involved in the progression of numerous fibrotic and age-related conditions.
Chronic inflammation causes tissue maintenance processes to run awry, and fibrosis, the inappropriate deposition of scar-like collagen structures that disrupt tissue function, is one of the possible outcomes.
Senescent Cells Provoke Excessive Sympathetic Nerve Fiber Growth, with Harmful Consequences
Senescent cells are created constantly throughout life in response to a range of circumstances, but only begin to accumulate in later life, once there is an imbalance between processes of creation (as a response to cell damage, for example) and processes of destruction (such as immune surveillance of senescent cells).
Senescent cells secrete a potent mix of signals that, when sustained over time, provokes chronic inflammation and alters nearby cell behavior and tissue structure in detrimental ways. Researchers are only now attempting to catalog exactly how senescent cells cause harm, given the advent of senolytic therapies that allow a good assessment of the degree to which senescent cell accumulation contributes to specific degenerative processes in aging.
A Continued Focus on Metformin, a Demonstrably Poor Approach to Treating Aging
Metformin is a poster child for the way in which much of the aging research community is focused on approaches to aging that cannot possibly achieve more than a very modest slowing of degeneration, and where the existing evidence strongly suggests that those tiny positive outcomes will be unreliable at best.
Metformin is a way to tinker with the operation of a damaged metabolism, not a way to repair that damage. As a calorie restriction mimetic, the animal data shows that it compares very poorly to calorie restriction itself. We know that calorie restriction doesn’t do anywhere near enough for human longevity. This is not the way forward to human rejuvenation.
A Hypoxia Mimetic Drug Improves the Bone Marrow Environment to Treat Osteoporosis
Researchers here show that an iron chelation drug (deferoxamine, brand name desferal) triggers a portion of the cellular reaction to hypoxia in bone marrow.
Hypoxia is one of the many types of stress that, when mild, induces cells to greater efforts in maintenance and repair, resulting in a net gain in cell function. In the rats treated with deferoxamine in this study, the hypoxia mimetic acts to reduce the burden of cellular senescence, and otherwise shift the behavior of cells in the direction of slowing the onset of osteoporosis.
Klotho Links Inflammation, Salt Sensitivity, Hypertension and Mortality in Aging
Klotho is one of the few robustly demonstrated longevity-associated genes. Greater expression extends life in mice, while reduced expression shortens life.
Present investigations of the mechanisms by which klotho produces effects on life span are largely focused on the direct actions of klotho in the kidney, and then the effects of kidney function on broader health.
Kidney function influences cardiovascular decline and the aging of other organs through a variety of mechanisms. While klotho level is well known to correlate with the degree of cognitive decline with age, this is most likely a demonstration of the importance of kidney function and cardiovascular function on overall health. The brain suffers when its supporting organ systems suffer.