Dear Future Centenarian

A bestselling book enters new markets and predicts Longevity Escape Velocity by 2029/30.

Longevity Escape Velocity (LEV) is a predicted situation in which life expectancy is extended longer than the time that is passing.

For example, in a given year in which longevity escape velocity would be maintained, technological advances would increase life expectancy more than the year that just went by.

The term “Longevity Escape Velocity” was coined by biogerentoloist Aubrey de Grey.

In the past, life expectancy at each age has increased slightly every year as treatment strategies and technologies have improved. At present, more than one year of research is required for each additional year of expected life.

Longevity escape velocity occurs when this ratio reverses, so that life expectancy increases faster than one year per one year of research.

Proponents include David Gobel, co-founder of the Methuselah Foundation and futurist and technologist Ray Kurzweil.

Kurzweil predicts that Longevity Escape Velocity will be reached before humanity will realize it. According to him, it will be reached in 8 to 10 years.

At that point in time which, once reached, it will define the ability for science to indefinitely prolong healthy life.

Kurzweil said “The next decade is going to be a profound revolution.” From there, he predicts nanorobots will “basically finish the job of the immune system,” with the ability to seek and destroy cancerous cells and repair damaged organs.

As we head into this sci-fi-like future, your most important job for the next decade or so is to stay alive.

Within a month or so, I will finish updating my 7 simple Steps to thrive at 100… and beyond which will show you how to stay healthy until Longevity Escape Velocity arrives. They will be encapsulated in seven e-books. When all seven are complete, I will show you where to download them for free.

It won’t be like turning on a switch either. This year, you might add a month or two to your expected lifespan. Then more every year until your goal is realized.

My friend, Jose Cordeiro and his co-author David Wood brought the Longevity Escape Velocity concept to Spanish, Portuguese and French speaking audiences in their best-selling book The Death of Death.

Both experienced speakers and writers, their combined knowledge of the Longevity field is considerable. Cordeiro is an engineer, economist, futurist and transhumanist, who has worked in different fields including economic development, international relations and is an international member of the World Academy of Arts and Sciences.

Wood , the creator of the world’s first operating system for smartphones, sits on the Board of Directors of the Institute for Ethics and Emerging Technologies.

They will also be releasing their book in Russian and in Chinese, with other international versions in the works.

Aging is a disease, the authors tell us, that can be cured and that must be cured. Progress in Longevity research means the death of death is achievable, says Cordeiro.

He goes as far as to indicate a timetable. “By 2029/30, so by the end of this decade,” Cordeiro says “we will have reached Longevity Escape Velocity.

“We believe that death will be optional by 2045, or even earlier, if more public and private funds are invested in rejuvenation technologies,” he says.

“Thanks to exponential advances in artificial intelligence, tissue regeneration, stem cell treatments, organ printing, cryopreservation, genetic or immunological therapies will solve – and are already solving – the problem of aging of the human body. By 2045, technology for rejuvenation will be very, very cheap.”

It comes down to a mental block, explains Cordeiro. “No-one likes to think about death, let alone their own death; we have a death mindset, but Longevity research is breaking that dogma by repairing aging damage and slowing aging and even reversing it.

“Our book seeks to change the public perception of aging, to disrupt the paradigm of accepting aging and death as inevitable consequences of life, to bring about the death of death itself.”

More Life,
David Kekich



Weekly News

Amyloidosis Contributes to Muscle Aging, and NAD+ Upregulation Reduces Amyloid Burden

Amyloids are misfolded proteins that can cause other molecules of the same protein to misfold in the same way, linking together into solid deposits that are disruptive to normal cell and tissue function.

Read More

Cellvie Seed Funded to Develop Mitochondrial Transplantation as a Therapy

Mitochondria are the power plants of the cell, producing chemical energy store molecules to power cellular processes. They are also embedded deeply into may core functions of the cell, from replication to programmed cell death.

Mitochondrial function declines throughout the body with age, for reasons that are likely downstream of other more fundamental damage. Mitochondrial dynamics change in ways that make mitochondria more resilient to removal via mitophagy when worn or broken, and mitophagy itself loses efficiency.

Read More

Debating the Connection Between Herpesvirus Infection and Alzheimer’s Disease

The role of persistent infection in the development of Alzheimer’s disease is much debated these days, particularly now that the amyloid cascade hypothesis is under attack, following the continued failure of trials for therapies that clear amyloid-?.

The biggest challenge in understanding Alzheimer’s disease is the question of why only some people develop the condition, even given very similar lifestyle choices relating to weight, exercise, and other well-known influences on health.

Read More

A New Era in Research into Aging, Focused on Intervention and Treatment

Past research into aging was characterized by a driving philosophy of “look but don’t touch”. Intervention in the aging process was presented as exclusively the domain of fraud, lies, and marketing, exemplified by the activities of anti-aging marketplace, all hope and non-functional potions.

To treat aging was an aspiration that every scientist was strongly encouraged to avoid by those who controlled the research agenda and its funding. This was the case from at least the 1970s until comparatively recently.

Read More

The Practice of Calorie Restriction Reduces Blood Pressure and Cardiovascular Risk

In today’s open access paper, the authors review the evidence for the practice of calorie restriction to reduce blood pressure and cardiovascular disease risk in human subjects.

Read More

Evidence for Microglia to be Involved in the Depression Accompanying Neurodegenerative Conditions

Chronic inflammation and activation of microglia in the brain may contribute to the depression that can accompany neurodegenerative conditions, as well as other diseases that feature persistently raised inflammation.

Read More

Towards a Universal Epigenetic Clock for Mammals

Epigenetic marks are constantly added to and removed from CpG sites on the genome, controlling gene expression and thus cell behavior. The pattern of epigenetic marks in any given cell shifts in response to environment and circumstances, and some of those changes are characteristic of the presence of the underlying molecular damage of aging.

Read More

Longevity Gene INDY is Involved in Blood Pressure Control

The INDY gene has been known to affect longevity in a range of species for quite some time, as I noted at length back in 2015. It is more than 20 years now since INDY was first discovered to affect fly aging, and work continues to link the outcomes on life span to specific effects on aging and cell function.

Read More

MOTS-c Upregulation Mimics Exercise to Improve Health and Extend Life in Mice

Upregulation of MOTS-c improves mitochondrial function and has other less well explored influences on stress responses in cells. This might be considered a form of exercise mimetic therapy, given that MOTS-c upregulation is one of the outcomes of exercise.

The result of artificial upregulation of MOTS-c in mice is improved health, greater exercise capacity, and extended life span.

Read More

Further Investigations of Partial, Transient Cellular Reprogramming

Reprogramming cells from old tissues into induced pluripotent stem cells has the effect of reversing many of the epigenetic changes that are characteristic of age, thus restoring mitochondrial function and other aspect of cell behavior.

Read More

An Example of Automating Nematode Lifespan Studies

The growth of interest in targeting mechanisms of aging has led to the development of a variety of approaches to automating nematode life span studies, some of which are already available as commercial services.

Read More

Notes on European Longevity Industry Startups

While much of the longevity industry is based in the US, there are a fair number of companies elsewhere in the world, working on approaches that target the mechanisms of aging in order to better treat age-related conditions or improve health in later life.

Read More

A Growing Interest in the Treatment of Aging as a Medical Condition

There is a growing interest in the treatment of aging as a medical condition, targeting mechanisms that cause aging or that are involved in the pathologies of aging.

Read More

Theorizing that Too Much Propionate Contributes to Alzheimer’s Disease

Proprionate is generated by gut microbes, and is generally thought to be beneficial, acting to improve measures of health. Thus it has been lumped in with butyrate and a few other metabolites as beneficial outputs of the gut microbe that decline with age as the microbial populations shift.

Read More

Accelerated Inflammatory Aging Observed in Alzheimer’s Disease Patients

Alzheimer’s disease, like many age-related conditions, has a strong inflammatory component.
Read More