Healthy Life Extension
Dear Future Centenarian,Â
You are basically¦ your brain.
Cut off an arm, and you are still œyou. But suffer a serious head injury, and you lose functionality. Get advanced Alzheimer™s, and you become demented. Eventually, you even lose your identity. Your sense of self.
And when you die¦ goodbye. At least as far as we know.
But wait. What if your brain can be preserved after death? Save your brain and save yourself?
You™re probably aware of cryonics by now. I™m a strong advocate and have been for over 30 years. Since then, the technology has come a long way. In fact, I think it™s viable. IMO, it will work.
But there are barriers. Even though the vast majority of members of cryonics organizations fund their suspension with life insurance, it leans toward the expensive side. And some simply can™t afford it. A deceased friend of mine lost his chance for a œsecond chance for this reason. And the world lost one of the best minds of our time in the process.
Then there are long term storage issues under liquid nitrogen temperatures. Although they are secure, they are not iron clad.
When it comes to your life, leave as little as possible to chance.
What if the cryonics hurdles were overcome? What if at death, you could have your brain chemically fixated for no higher cost than conventional burials or even cremations? And what if it could be stored at room temperature in any secure place in the world? And what if you had the same chance of being revived with future technologies aggregates and rescuing your memory, your personality and your sense of œself as cryonics offers?
That may be possible.
Don™t worry about your body. Seriously. If you haven™t cryonically preserved it too, growing a new stronger one should be routine if your brain could be revived. Worry about survival first if extreme healthy longevity is your goal.
For now, cryonics is your only option for your memory and identity to survive legally defined death.
But I™m here to tell you something you have probably not heard before.
Neuroscientists today can preserve small volumes (<1mmÂ³) of animal brain tissue immediately after death with incredible precision. The features and structure of every synapse within these volumes is well-protected down to the nanometer scale, using an inexpensive, room-temperature process of chemical fixation and plastic embedding, or "plastination."
And this may someday be your ticket to the future.
Lots of research is neededÂ though, and you can help without spending a dime.
The Brain Preservation Research Foundation (BPF) is engaged in a competition for $60,000 of funds right now, which they sorely need for research and equipment. A few more Facebook likes between now and 11/23, and they should win those funds.
Please donate five minutes of your time. You can greatly help BPF (www.brainpreservation.org ) win the funds for their brain preservation research.Â
Whichever of four brain research charities receives the most Likes at http://on.fb.me/17Hd6JP by 11/23/13 will receive these funds from Steve Aoki's Charity Fund. They are currently in Second Place, just 90 Facebook "Likes" behind the leader, the University of Rochester Memory Care Program.
This is the first time BPF has gone up against more conventional brain research charities in open funding competition.
So I™m asking you to œLike BPF on Facebook. And please invite all of your Facebook friends to Vote to Save Brains BPF Facebook event.
Here™s how to do this:
- Install the Invite All browser plugin, while using the Chrome browser (20 seconds).
- Go to the Vote to Save Brains Facebook event, click to join it, and then you'll see an "Invite Friends" button. Click that, and all your friends will pop up in a dialog box, with a "Select All" button.
Click that, wait while the script scrolls to the bottom of the box. When it hits the bottom click "Save". If you have many FB friends, you'll have to wait another [1 - 2] minutes. for a Captcha to come up.
Enter the numbers you see, and then you'll get a confirm message that all your friends have been invited.
Presto. In the time you take to brush your teeth, you may have pushed this important initiative over the top.
Tiny contributions of your time here and there can go viral before you know it. And once that happens, the positive impacts on aging research can be enormous¦ well beyond winning this critical $60,000 prize.
Tand your loved ones?
P.S. At Maximum Life Foundation, we spend all day, seven days a week in pursuit of longevity. We don™t expect you to do that. But we do hope you will take five minutes NOW on this initiative.
Latest Headlines from Fight Aging!
Potential for Photoacoustic Therapy to Target Protein Aggregates in Neurodegenerative Disease - Monday, November 4, 2013
Photoacoustic therapy involves the use of carefully modulated laser light to rapidly dump energy into very specific locations in a tissue, where flash heating will destroy the intended target.
Work to date involves, for example, delivering carbon nanotubes to cancer cells and then using laser light to explode the nanotubes. Researchers are now considering the potential for forms of photoacoustic therapy to destroy aggregates of misfolded proteins associated with neurodegenerative disease.
This may be overly optimistic on a few counts: firstly that the amyloid is definitely the disease agent in all cases, versus a secondary effect - though the research community should still work to remove it, as it is an enumerated difference between healthy and diseased tissue. Secondly it may not be as straightforward as hoped to deliver heat via laser only to amyloid without causing secondary damage to delicate nearby structures in neurons and synapses.
You might recall that a community-funded attempt to break down liposfuscin through modulated laser light didn't go so well on that count. It proved more challenging than expected to keep the heat and damage constrained to just the lipofuscin. Still, this should just be another technical hurdle to overcome.
A Popular Science Article on the Comparative Study of Aging in Short-Lived and Long-Lived Species - Monday, November 4, 2013
Looking for longevity-assurance mechanisms in long-lived animals is a growth concern these days, though it is still largely an aspect of the slow road in longevity science.
Slowing aging safely by creating a new operating state for our cellular biology is a very challenging and expensive endeavor, and one which will yield little benefit for people who are already old. In comparison keeping the metabolism we have while working to periodically remove the damage that degrades its operation sounds like a much better plan, and one that will help the old by actually rejuvenating them.
Here is a popular science piece that looks at the work of one of the researchers involved in comparative studies of the genetics of aging in varied animal species.
The Science of Staying Younger Longer - Tuesday, November 5, 2013
It is pleasant to see larger, more conservative research institutions being much more aggressive in publicizing longevity science and the goal of extending the healthy human life span. It shows that the old scientific and funding institution culture of hiding and suppressing any work on aging that might be relevant to extending life is done with and over.
When the research community talks openly about their goals, levels of funding and public support rise. Nowadays the more important battle is fought to ensure that the best strategies for extending life are those that are funded: for example none of the lines of research mentioned in the article below are in any way relevant to the SENS vision of rejuvenation through damage repair.
Despite the talk of rejuvenation they instead reflect the mainstream focus on altering genes and metabolism to slow down the progression of aging, which is a harder, slower, less certain road to a less useful outcome.
Born Too Early? - Tuesday, November 5, 2013
Practical human rejuvenation lies in the near future: the means to reverse age-related degeneration and restore youthful function to the old, thereby extending healthy life and eliminating age-related disease.
With the right sea changes in scientific funding, so that organizations like the SENS Research Foundation become the mainstream of the aging research community, rejuvenation therapies could well arrive by the late 2030s. If the present mainstream focus on gently slowing aging continues as is, however, then it will take much longer to realize rejuvenation. But however long it takes, some fraction of those people presently alive will have been born too early.
From where I stand, the best thing to do is not to agonize over the odds but rather work to help shape the odds. Donate to research, persuade your friends, advocate for rejuvenation science, help make cryonics an ever more viable alternative for those who do not have enough time to wait for life-extending therapies, and more. There is plenty that can be done, and still all too few people working on it.
Evaluating Autologous Stem Cell Therapy for Peripheral Artery Disease - Wednesday, November 6, 2013
VesCell was one of the first of the present generation of commercialized stem cell therapies in which a patient's own cells are taken, expanded, and then returned to the body.
The company was notable for marketing in the US while setting up clinics elsewhere in the world to evade onerous FDA restrictions on stem cell therapies: medical tourism at its finest. These sorts of treatments are only now becoming available in the US thanks to the fact that over the past fifteen years a range of pioneers successfully developed commercial clinical applications beyond the reach of US regulators.
Otherwise we'd still be waiting and FDA bureaucrats would still be forbidding commercialization of stem cell research, demanding ever more trials and data.
Treating Traumatic Brain Injury With Stem Cells - Wednesday, November 6, 2013
Here is one example drawn from many ongoing lines of research aimed at the development of stem cell treatments for a broad variety of injuries. Enhanced regeneration will be a strong theme in the new medical technologies of the next two decades.
An Interesting Approach to Finding Longevity-Associated Genetic Variations - Thursday, November 7, 2013
Researchers here use dead people as their initial study group, an approach which has some advantages.
One could imagine setting up a very large and cost-effective study based on introducing a simple skin sample procedure into standard end of life medical care, and then matching those results to genetic data drawn from existing large studies of old people. Researchers would only have to match age and gender between the deceased and living individuals from another body of study results in order to start producing value.
Considering Impairment of Regeneration in Aging - Thursday, November 7, 2013
There is much debate over the origins and causes of the well-known decline in regenerative capability with age, characterized by reduced numbers of stem cells and reduced stem cell activity in tissue maintenance, among other mechanisms.
A mainstream position is that this is an evolved response to damage, lengthening life by reducing the risk of cancer that might result from damaged stem cells, but at the cost of increasing frailty. There are other views, of course.
More on Lin28a and Enhanced Regeneration Â - Friday, November 8, 2013
Here is a better set of publicity materials describing recent research in which scientists demonstrated enhanced regeneration in mice.
A Scaffold Patch Combined With Gene Delivery Regrows Bone - Friday, November 8, 2013
One branch of tissue engineering focuses on the creation of scaffolds that mimic enough of the features of the extracellular matrix or local cellular environment to encourage regrowth. With suitable chemical signals a scaffold can guide the normal processes of regeneration to fill out its structure with suitable tissue, as demonstrated here for bone regrowth.
DISCLAIMER:Â News summaries are reported by third parties, and there is no guarantee of accuracy. This newsletter is not meant to substitute for your personal due diligence and is not to be taken as medical advice. For originating report, please see www.fightaging.org/
David A. Kekich
Maximum Life Foundation
"Where Biotech, Infotech and Nanotech
Â Â Â Â Meet to Reverse Aging by 2033"