Longevity News Digest

Funding Aging Research

Your Blood¦ or Your Life

Dear Future Centenarian,

Would you trade your life for a small vial of your blood? Millions of uninformed people unwittingly do just that.

Imagine a pair of identical twins. Twin A is 79 years old. Active, energetic, lean. His biological tests predict he will stay vibrant for ten more years minimum¦ assuming he follows his current lifestyle.

Twin B? He died eleven years ago after six years of agony, the last two in a nursing home. Toward the end¦ he couldn™t even feed himself.

Why the difference, especially when they were identical in nearly every way, including their lifestyle habits?

It started with a routine blood test that someone talked twin A into over twenty years ago. Twin B wasn™t interested.

Twin A had his CRP levels tested. This simple blood test most likely saved his life. Ignoring it could cost you yours. Getting it could also result in your improved healthier body “ and a sharper mind built to last.

C-reactive protein, or CRP, has long been used as a reliable marker of inflammation in the body.

High CRP levels are found in practically EVERY known inflammatory state. Even if you have no symptoms of disease, elevated CRP levels may signal an increased risk for practically ALL degenerative disorders, including cardiovascular disease, cancer, obesity, diabetes, arthritis and more.

Twin A™s doctor explained this to him. Even though he felt fine, he took protective measures to stem the tide and to undo the silent toll chronic inflammation likely was taking on him. He modified his diet, started a conservative exercise program, added nutritional supplements and quit smoking.

Recently, researchers discovered that CRP turns out to be more than just a marker of inflammation. It also causes inflammation.

Not knowing your CRP puts you at a HUGE disadvantage.

When CRP rises unchecked, it can contribute to destructive chronic inflammation. If it™s elevated, you can take proactive steps to lower it. But if you don™t know what it is, it could steadily unleash an accelerating cascade of irreversible damage to your vital organs.

Lowering CRP levels then, is a vital part of a healthy lifestyle. Fortunately, we have natural ways to address chronic inflammation. You can find simple ways by CLICKING HERE for a free report which tells you what you can start doing now if your CRP level is high.

Get your CRP tested, and get started today on lifestyle changes that can work for you. Some safe, affordable nutritional supplements may offer immediate help too.

Even otherwise healthy people with modestly raised CRP levels have a significantly higher risk of future cardiovascular events and a higher risk of complications.

CRP is also associated with other cardiovascular-related conditions such as high blood pressure. In addition to being a marker of risk, there is growing evidence that CRP contributes directly to cardiovascular and diabetes risk.

In one study, women with the highest CRP levels had a 16-fold risk for developing diabetes compared with those at the lowest levels.

Strong evidence shows that CRP is an active (and destructive) participant in promoting inflammation. And in addition, there™s equally strong interest in discovering ways to actively lower a person™s CRP levels to reduce their cancer risk”or to promote their recovery if they already have cancer.

In breast cancer for example, a CRP level of greater than 10 mg/L, compared with a level of less than 1 mg/L predicted a 96% greater risk of dying from any cause, a 91% greater risk of dying from breast cancer specifically, and a 69% greater risk of having additional breast cancer-related events.

By lowering your CRP, you™ll be taking a critical first step to protect yourself against chronic inflammation before it progresses to a life-threatening disease.

Optimal levels for women are 1 mg/L or lower and 0.55 mg/L for men.

Learn what to do NOW.

More Life,
David Kekich

P. S. Special thanks to Life Extension for inspiring this email and for providing some of the information.

Latest Headlines from Fight Aging!

Selection Effects of Human Longevity Genes are Decreasing – Monday, May 12, 2014
When considering survival in early old age lifestyle is more important than genetics, but genetic lineage becomes increasingly important for survival in extreme old age.

This is reflected in the increased frequency of the few known genetic variants associated with longevity in older populations: those without the variants have a higher mortality rate, and so the relative proportion of those with the variants rises over time.

Researchers here demonstrate that this effect has been gently diminishing in recent decades, and thus cohorts of the oldest people born more recently include more individuals without longevity-associated genetic variants. This would be the expected outcome in an environment of consistently improving medical technology.

Past improvements in medicine have only indirectly impacted the processes that drive aging, however, or provide only limited benefits to people suffering from age-related conditions because the treatments don’t address the underlying causes of aging. They are essentially patches on a fast-growing hole, which is better than nothing, but not a solution.

Read More https://www.fightaging.org/archives/2014/05/selection-effects-of-human-longevity-genes-are-decreasing.php

The Fear of Growing Old: Tithonus and Centenarians – Monday, May 12, 2014
It is thought that one of the greatest hurdles to growth in public support of longevity science is the fact that most people assume increased longevity through medicine would mean being old, frail, and in pain for longer.

This is very much not the case, however: the goal is always to extend or restore the period of healthy life, and given that aging is an accumulation of damage in and between cells it might not even be possible to engineer a situation in which people are older for longer rather than younger for longer.

Either you repair the underlying damage that causes aging by implementing something like the SENS research program, in which case people will be all-round healthier for longer, or you don’t. In the latter case you have the present situation in mainstream medicine of an expensive, only marginally beneficial, and ultimately futile process of trying to keep heavily damaged machinery running at all.

The state of present mainstream medicine is what people see and what they assume to be the case in the future, however. It is strange that we live in a time of constant change, and yet the average fellow in the street assumes that the present is a good model for what lies ahead.

The relationship between aging and medicine is about to change radically, as the research community for the first time works towards directly treating the causes of aging. But to make good progress here, to raise the necessary funds, the public must be on board and supportive in the same way as they are for stem cell research or cancer research. That has yet to happen, however, and this is why we need advocacy and persuasion.

Read More https://www.fightaging.org/archives/2014/05/the-fear-of-growing-old-tithonus-and-centenarians.php

Examining Mitochondria in Long-Lived Individuals – Tuesday, May 13, 2014
A part of the genetic contribution to survival to extreme old age may have to do with adaptations allowing for better mitochondrial function despite accumulated damage.

Or it could be the case that in extreme old age mitochondria are significantly different in structure to merely old age, and this is a global phenomenon for all who make it that far. Either way, this is interesting research; you might want to skip to figure 6 in the discussion section of the paper for a graphical summary of the authors’ hypothesis.

Read More https://www.fightaging.org/archives/2014/05/examining-mitochondria-in-long-lived-individuals.php

Shorter Men Have a Longer Life Expectancy – Tuesday, May 13, 2014
There is plenty of evidence to show that shorter people tend to live longer. Here is more of the same.

Read More https://www.fightaging.org/archives/2014/05/shorter-men-have-a-longer-life-expectancy.php

Reinforcing Microtubules as an Alzheimer’s Treatment – Wednesday, May 14, 2014
A number of approaches to Alzheimer’s disease don’t seek to address the underlying causes of pathology, but rather shore up crucial mechanisms that are harmed.

This approach is actually very common throughout modern medicine, and it is something that I think has to change in order to improve the effectiveness of medical research and development. This is an example of the type.

Read More https://www.fightaging.org/archives/2014/05/reinforcing-microtubules-as-an-alzheimers-treatment.php

Early Calorie Restriction Extends Life in Mice – Wednesday, May 14, 2014
Reducing calorie intake for a comparatively short period of time very early in life is here shown to have life-long effects in mice. This provides more insight into the way in which metabolism in shorter-lived mammals has evolved to react to temporary famine conditions, producing more robust health and up to 40% longer life spans for life-long calorie restriction.

It is interesting that even a short period of low calorie intake early in life can have the effects noted in this study.

We humans share the same evolutionary heritage of nutrient sensing mechanisms intended to alter our metabolic processes based on calorie intake, and the beneficial effects of calorie restriction on measures of health are quite similar to those in mice, but calorie restriction doesn’t extend our life by anywhere near the same proportion.

The consensus in the scientific community is that calorie restriction will extend human life by perhaps 5% or a little more. On the other hand, the health benefits are greater than those produced by any presently available medical technology or lifestyle choice.

Read More https://www.fightaging.org/archives/2014/05/early-calorie-restriction-extends-life-in-mice.php

Sensing Lack of Water Extends Life in Flies – Thursday, May 15, 2014
It is well known that calorie restriction extends life in near all species in which it has been tested. In mammals much of this effect seems to operate through sensing low levels of methionine, an essential amino acid.

Here researchers show that in flies in addition to mechanisms that react to the level of food intake there is also water sensor that separately and distinctly alters metabolism so as to extend healthy life.

Read More https://www.fightaging.org/archives/2014/05/sensing-lack-of-water-extends-life-in-flies.php

Chronic Obstructive Pulmonary Disease is not an Age-Related Condition – Thursday, May 15, 2014
There are many ways in which you can sabotage your future health, but putting on weight and smoking are the most popular choices.

They even have similar harmful effects on life expectancy: a decade or more of life lost. At the level of cells and tissue structures the effects of smoking look a lot like accelerated aging in some ways – which should not be surprising if we consider aging as nothing more than accumulated damage to the biological machinery of the body. This is a theme taken up in the paper quoted here.

Read More https://www.fightaging.org/archives/2014/05/chronic-obstructive-pulmonary-disease-is-not-an-age-related-condition.php

Neural Precursor Cells Induce Repair of Myelin Loss in Mice – Friday, May 16, 2014
Myelin is the sheathing of nerves, and loss of myelin contributes to a number of debilitating diseases.

This loss is also shown to occur to a lesser degree in aging, so just as for many types of disease it is worth keeping an eye on the progression of treatments such as the one discussed here. This paper is open access, but the full version is in PDF format only at the moment.

Read More https://www.fightaging.org/archives/2014/05/neural-precursor-cells-induce-repair-of-myelin-loss-in-mice.php

Induced Pluripotent Stem Cell Therapy Tested in Primates – Friday, May 16, 2014
Work progresses on therapies that use reprogrammed stem cells derived from easily obtained patient tissue samples, such as small pieces of skin.

Read More https://www.fightaging.org/archives/2014/05/induced-pluripotent-stem-cell-therapy-tested-in-primates.php

DISCLAIMER:  News summaries are reported by third parties, and there is no guarantee of accuracy. This newsletter is not meant to substitute for your personal due diligence and is not to be taken as medical advice. For originating report, please see www.fightaging.org/

David A. Kekich
Maximum Life Foundation

“Where Biotech, Infotech and Nanotech
     Meet to Reverse Aging by 2033″


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