Healthy Life Extension
What Will Humans Look Like in 2033?
Dear Future Centenarian,
We won™t look much different than we do now, but we may SEE much better.
Not only that, but we should look, perform and feel much better too. I invite you to check out this video to see what is happening in that regard today. And as the carney barker says, œYou ain™t seen nothin™ yet.
In case you didn™t click on that link, let me tell you what you may want to see:
- Today™s cyborgs: Losing a limb, an eye and other body parts isn™t what it used to be.
- How man and machines are merging, and why we humans will be superhuman.
- Brain/machine interfaces¦ and just SOME of the implications.
- Will we someday OPT for prosthetics and trash our limbs¦ and even organs?
Some of this scares many people. It™s perfectly okay, and even desirable to replace a lost limb. But would it be okay to replace our legs with prosthetics to make us faster, stronger, more durable and injury-proof?
How about augmenting our brains so we can think faster, remember better and just be¦ well¦ smarter?
Physically and mentally speaking, our futures are bright. Besides being stronger and smarter, how about aches and pains? For the most part, probably history.
Parkinson™s patients have had chips implanted in their brains for years to mitigate their symptoms. Paralyzed people wirelessly control computers, wheelchairs and more with their thoughts, thanks to neural implants.
Why should they be the œlucky ones. With more advancements in the technologies, which are accelerating at lightning speed by the way, why shouldn™t we be able to do the same “ but way more? Imagine accessing any information you want from the Internet, simply by thinking your question.
We™ve already started down this path, and you may be faced with some of these options sooner than you think. When you are, I wonder how you will react. And we™ve just scratched the surface of endless possibilities.
One thing™s certain. Most who resist these possibilities today will embrace them once they become commonplace. It wasn™t too long ago that conventional wisdom dictated that anesthesia for childbirth should be forbidden.
Times change¦ and so will we.
LATEST HEADLINES FROM FIGHT AGING!
CALORIE RESTRICTION PROTECTIVE OF SPECIFIC BRAIN MECHANISMS Friday, MarchÂ 1, 2013
Calorie restriction produces a general slowing of the progression of degenerative aging and creates sweeping changes at all levels of metabolism.
Thus it should not be a surprise to find protective effects no matter how deep you dive into the biochemistry of calorie restricted laboratory animals. Here's one of the many more detailed examples, looking at the abundances of receptors known to be important in brain function:
ANOTHER STUDY ON INHERITANCE OF HUMAN LONGEVITY Friday, MarchÂ 1, 2013
Studies suggest that longer life expectancy runs in families to some degree - though it is always the case that what you get in the genetic lottery can be squandered by poor lifestyle choices.
Gene variants appear to be more important in determining remaining life expectancy at older ages than at younger ages, which is another way of saying much the same thing. Either way, the end result will be the same until we can build rejuvenation biotechnology.
INFUSING LARGE NUMBERS OF IMMUNE CELLS AS A THERAPY Thursday, February 28, 2013
Since it is possible to take a patient's cells and generate a very large number of immune cells, far more than the patient would ever have normally, and since it's possible to make some alterations to immune cells to make them more effective, why not do this?
ONE VIEW OF THE WIDESPREAD UNTHOUGHT OPPOSITION TO ENGINEERED HUMAN LONGEVITY Thursday, February 28, 2013
The average fellow in the street thinks that helping people to live longer is a bad idea, and usually expresses some combination of the Tithonus Error (the misapprehension that life extension technologies would make you live in increasing frailty, rather than extending youth) and the modern mixed package of environmentalist / classist / Malthusian / conservative beliefs on wealth and privilege:
that equality should come by tearing down those at the top and halting progress, that there are too many people in the world, that any sort of increased consumption is evil, that changing anything to do with aging is bad.
CAUTIOUS STUDIES TEND TO DISPROVE DIETARY LONGEVITY CLAIMS Wednesday, February 27, 2013
A research group is presently working through a grand tour of replicating longevity claims in mice, using careful and cautious study designs that eliminate calorie restriction effects as much as is possible.
This sort of approach shows that many past claims of dietary additions that modestly extend life in mice were probably the result of inadvertent calorie restriction - which is why you have to look carefully at every study to make sure that researchers controlled for this issue.
A PODCAST INTERVIEW WITH AUBREY DE GREY Wednesday, February 27, 2013
An audio interview with Aubrey de Grey of the SENS Research Foundation: "Like it or not, aging is a byproduct of the daily activity of life.
But Aubrey de Grey believes that the molecular and cellular damage that defines aging and creates disability and disease can be targeted for medical interventions that restore health and radically extend life.
PARTHOGENESIS IN REGENERATIVE MEDICINE Tuesday, February 26, 2013
This popular science piece looks at parthogenesis as an alternative to both embryonic stem cells and induced pluripotency reprogramming as a source of stem cells:
"Parthenogenesis is a form of asexual reproduction that occurs naturally in plants, insects, fish, amphibians and reptiles.
VERY HEALTHY ELDER ATHLETES DON'T ACTUALLY TELL US ALL THAT MUCH ABOUT AGING Tuesday, February 26, 2013
A number of studies have shown that it is possible to be both old and very healthy in comparison to your peers, and surveying older athletes is a good way to find some of those old, very healthy people.
The big question is one of causation: are they healthy because they are athletes, or did they become healthy athletes because they are more physically robust, thanks to genetic or other differences?
SENS RESEARCH FOUNDATION SITE REDESIGN Monday, February 25, 2013
The SENS Research Foundation works on the foundational biotechnologies that will be needed to create therapies capable of reversing aging: ways to make mitochondrial DNA damage irrelevant, removing harmful aggregates that build up with age within and between cells, and so forth.
CONSIDERING DNA METHYLATION AND AGING Monday, February 25, 2013
An article on DNA methylation, which researchers have demonstrated to have the basis for a biomarker of aging; some of the patterns that tend to occur in the way in which these epigenetic decorations to DNA occur correlate well with biological age.
This author is optimistic that manipulating DNA methylation can slow aging, which is something of a programmed aging point of view - that epigenetic changes are a root cause of aging and give rise to the damage of aging we can observe, rather than vice versa.