Dear Future Centenarian,

I was in a hospital for over a week for a surgery on the spinal surgery wound from my original surgery on 3/31. I have a post-surgical infection and complications that have made existence next to impossible these past 5 weeks.

The bug has not yet been identified but appears to be a bone infection. We hope to have it identified this week.

I had a PICC line installed and am learning how to inject two antibiotics 4 times a day for the next six weeks. You may have read how Prof. Joe Carrington saved my life in December. Now, four months later, he might have done it again in collaboration with my primary physician.

Sick or healthy, Joe should be your medical consultant. He gets results where few in this world can.

Most change in life comes through adversity. Most breakthroughs come out of having to break something. For me, that has been the aging process over the past 22 years. That’s still my mission, but for now, I need to get through each day until I beat this infection and get back to being functional.

If you look at times in your Life where you had the greatest awareness or greatest shift, it’s probable it came out of pain.

Maybe someone died who was close to you.

Maybe you had a breakup that felt like your heart had been ripped out of your chest.

Maybe you had another traumatic experience.

But in one way or another, it’s the suffering, diseases and conditions of aging that catch up to ALL of us who escape an unlucky premature death.

There are areas of life that work and areas of life that don’t work.

Most lessons and breakthroughs come out of an area of life that doesn’t work and you’re forced to face it, and make a change.

Aging and vitality do not go hand-in-hand. But finally, with new and emerging technologies, they are already starting to. If you follow the advice in my 7 new free e-books, you could slash your odds of ever getting an aging-related disease or condition… plus you could add enough active years to see and incorporate full age-reversal capabilities.

Make the choice to grow younger.

More Life,
David Kekich



Weekly News

The Future of Cryopreservation

The ability to cryopreserve and thaw organs via vitrification, without ice formation and significant tissue damage, allowing for indefinite storage time, would go a long way towards simplifying the logistics and reducing the costs of present organ donation and future tissue engineering of organs for transplantation.

Cryopreservation via vitrification also offers the possibility of indefinitely storing the terminally ill and recently deceased until such time as medical science advances to the point of restoration. This has been practiced for several decades by the small cryonics industry.

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Does the Gut Microbiome Contribute to Age-Related Anabolic Resistance

The gut microbiome is a highly varied collection of microbial populations that acts in symbiosis with the body to process food and provide needed metabolites.

With age, there is a detrimental shift in these populations. Those generating useful metabolites, such as butyrate, iminish in number. Those capable of infiltrating tissue, generating inflammatory compounds, or otherwise interacting with the immune system to provoke chronic inflammation increase in number.

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Nicotinamide Riboside Supplementation Beginning in Mid-Life Slows Osteoporosis in Mice

In today’s open access paper, researchers report that long-term supplementation with nicotinamide riboside in mice, starting from mid-life and continuing into old age, slows the pace of osteoporosis.

The extracellular matrix of bone tissue is constantly remodeled over time, broken down by osteoclasts and built up by osteoblasts. Osteoporosis is caused by a growing imbalance between these two processes that favors destruction over creation. Bones lose mass and become brittle as a result, eventually becoming a serious health issue.

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A Gene Therapy Platform Applied to Skin Rejuvenation

MRBL is one of the many projects relevant to the treatment of aging that is in George Church’s orbit.

This is a collection of gene therapy technologies intended for delivery of vectors to areas of skin directly, coupled with analysis of age-related and disease-related gene expression changes in skin cell populations to provide targets. It is a viewed as a basis for approaches in cell reprogramming that could make aged skin cells behave in a more youthful fashion, overriding their response to the age-damaged local environment.

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It is Faintly Ridiculous to Propose that Human Life Span Cannot be Increased by Altering Metabolism

Today’s open access commentary is, I think, an overreaction to present challenges in engineering greater longevity via metabolic manipulation.

I would be the first to say that altering the operation of metabolism is not a good path forward, at least if the goal is to engineer greater healthy longevity in our species. Cellular metabolism and its intersection with aging is ferociously complex and poorly understood in detail.

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Cap-Independent Translation of mRNA as a Common Mechanism of Longevity

Researchers here show that increased levels of cap-independent translation (CIT) of messenger RNA (mRNA) take place in a diverse set of interventions known to modestly slow aging in mice, suggesting it to be a common phenomenon in these shifts of metabolism towards a slower pace of aging.

CIT is a process that in part drives the movement of mRNA, produced from genetic blueprints, into ribosomes for the production of proteins. Since protein levels determine cell behavior, the way in which translation of mRNA into proteins takes place is important. The work here makes a compelling case to link altered CIT levels to mTORC1 inhibition, suggesting that mTOR, already a popular area of study, may play a role in more age-slowing interventions than thought.

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A Model to Demonstrate the Excessive T Cell Expansion and Differentiation of an Aged Immune System Produces Chronic Inflammation in Tissues

Researchers here use a novel model to demonstrate that T cells made to exhibiting the greater replication and differentiation characteristic of an aged immune system, leading to cellular senescence, cause chronic inflammation in heart tissue in young animals.

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Targeting Cell Maintenance Processes to Improve Mitochondrial Function and Slow Aging

Many approaches shown to slow aging in animal studies involve an increased efficiency of cell maintenance processes such as the ubiquitin-proteasome system and various types of autophagy. Here researchers discuss the improvement of autophagy in order to slow the age-related decline of mitochondrial function.

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Loss of Neurogenesis with Age is in Part Mediated by Inflammatory Signaling in the Brain

The immune system is intimately involved in tissue function throughout the body, but particularly so in the brain.

The immune system of the brain is distinct from that of the rest of the body, the two separated by the blood-brain barrier, and the immune cells of the brain participate in a range of activities necessary to the function of neurons, as well as the creation, destruction, and maintenance of synaptic connections between neurons.

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In Horses, the Gut Microbiome Interacts with Mitochondria to Improve Function

The study here is carried out in horses, but it is reasonable to expect to find very similar mechanisms in other mammals.

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Noting the Work of Jim Mellon to Advance the Longevity Industry and Related Research

In the past few years Jim Mellon, high net worth investor and philanthropist, has put in a great deal of time and effort to help push forward the development of a biotech industry focused on intervention in human aging.

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COVID-19 Data Shows the Importance of Thymic Atrophy in Aging

The decline of the immune system is of great importance in aging. Vulnerability to infection, a decreased surveillance of senescent cells and cancerous cells, and growing chronic inflammation all take their toll.

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Yuva Biosciences as an Example of the Cosmeceuticals Path to Development of Aging Interventions

Yuva Biosciences is attempting to treat skin aging by improving mitochondrial function, and they are taking a cosmeceutical approach.

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Lysosomal Dysfunction and the Death of Neurons via Ferroptosis

Here find supporting evidence for the SENS view of lipofuscin and lysosomal dysfunction in aging. Lysosomes are the recycling units of the cell, packed with enzymes to break down unwanted structures and molecules into raw materials.

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Treating Sleep Apnea Lowers Dementia Risk By 20-30%

The results of this epidemiological study suggest that suffering from untreated sleep apnea can raise the risk of later dementia and mild cognitive impairment by 20-30%.

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