Anti Aging Research, Increasing Lifespan

Increasing Lifespans

Funding Aging Research

How to Live to 150

posted on March 10, 2009

Did you know bamboo is the fastest growing plant?  Some species grow four feet in one day! Bamboo reaches full height in one growth spurt of about two months.

But don™t plant it today and expect a crop tomorrow. It grows very little for the first 4 years. But then, suddenly in the 5th year, plants grow 80-90 feet tall. It takes bamboo about three full years, in the ground, before the mother plants really take off. Most of the bamboo grove slowly builds up steam underground, where you don™t notice it.

That™s how life is in general, and I™ll show you how understanding this could be critical to your continued health.

œOvernight successes usually burst on the scene after years and years of painstaking training, practice and education in anonymity. And it™s the same with research. Stem Cell Products is finally ready to launch some amazing anti-aging nutraceuticals and cosmeceuticals. It™s been over three years since the company was founded. And ten years of research preceded that. When the public will be saying œOh wow! management will be saying œAt last!

Here™s an even more dramatic example of an overnight success:

In 1980, Dr. Michael Rose began his quest for radical intervention in the aging process. Dr. Rose is an evolutionary biologist, and he has been able to increase the lifespans of his lab animals by over 400%. Here it is, almost 29 years later, when he is finally able to turn his research into products that could enhance and extend your life.

Following are some words from Dr. Gregory Benford, Chairman of Genescient, Inc, the company that is developing products based on Dr. Rose™s research


œI expect to see this happen says Dr. Benford, œbecause I'll be living longer. Maybe even to 150, about 30 more years than any human is known to have lived. (BTW, he is 68 years old now.)

œI expect this because I've worked on it, seen the consequences of genomics when applied to the complex problem of our aging. Genomics now reveals how complex the pathology of aging really is. We can't solve the aging problem using the standard research methods of cell biology, despite the great success such methods had with some other medical problems.

He goes on to say how aging comes from multiple genetic deficiencies, not a single biochemical problem.

But now we have genomics to reveal all the genes in an organism. More, we can monitor how each and every one of them expresses in your body. He says the aging riddle is inherently genomic in scale. There is no biochemical or cellular necessity to aging”it arises from side effects of evolution, through natural selection. But this also means we can attack it by using directed evolution.

Dr. Rose has produced "Methuselah flies" that live over four times longer than control flies in the lab. He did this by not allowing their eggs to hatch, until half are dead, for hundreds of generations. Methuselah flies are more robust, not less, and so resist stress. Methuselah flies genomics shows us densely overlapping pathways. Directed evolution uses these to enhance longevity. Since flies have about ? of their genes in common with us, this tells us much about our own pathways.

By finding substances that can enhance the action of those pathways, we have a 21st Century approach to aging. Such research is rapidly ongoing. The field is moving fast. Dr. Rose will introduce his first product to the market this summer that helps regulate 40 aging genes.

There seems no fundamental reason why we cannot live to 150 years or longer. After all, nature has done quite well on her own. We know of a 4,800-year-old bristlecone pine, a 400 year old clam”plus whales, a tortoise and koi fish over 200 years old”all without technology. These organisms use pathways we share, and can now understand. As I have pointed out in the past, if you can live to 150, or a lot less long, researchers say the restrictions on open-ended lifespans will be off.

Overnight success technologies are perfect illustrations of why it™s so critical for you to preserve and extend your health now. As more and more of these breakthroughs explode on the scene after years of brain sweating research, the greater your chances are for using them to launch you to a limitless future. Big breakthroughs could be right around the corner, so increase your odds to see them.

The first person to live to 150 may be reading this right now, or it might have been written by that person.


Faking Calorie Restriction (March 06 2009)
Via the Times of India, which somewhat misses the point by focusing on sugar rather than food in general: "over-consumption of sugar is directly linked to aging. The researchers, however, say that it's not sugar itself that is important in this process, but rather the ability of cells to sense its presence, that affects the lifespan of a person. The study found that if they removed the gene for a glucose sensor from yeast cells, they lived just as long as those living on a glucose-restricted diet. This implies that the fate of these cells doesn't depend on what they eat, but on what they think they're eating, according to the researchers. It was found that the lifespan of yeast cells increased when glucose was decreased from their diet. They then asked whether the increase in lifespan was due to cells decreasing their ability to produce energy or to the decrease in signal to the cells by the glucose sensor. The scientists found that cells unable to consume glucose as energy source are still sensitive to the pro-aging effects of glucose. On the other hand, obliterating the sensor that measures the levels of glucose significantly increased lifespan." It will be interesting to see whether this is also true - and/or useful - in mammalian cells, and perhaps the basis of a different approach for calorie restriction mimetics.

Aspiring to Longevity (March 06 2009)
A somewhat rambling and superficial look at aspirations to longevity, scientific and poetic, from the Vancouver Sun: "Now, say some longevity experts, [greatly extended healthy life] may be within reach of scientists working in air-conditioned labs to unravel the genetic code, map the hidden processes of the immune system, explore nanotechnologies that could make possible repairs to body structures too tiny to see and to develop ways to grow or construct and then safely install new or synthetic body parts. We don't blink at new hip joints, transplanted heart valves or minuscule plastic lenses that unfold inside the eye like flowers following cataract surgery, longevity advocates argue, so what's surprising about the looming possibility of even more extensive and complex replacements? We are now beginning to talk about curing old age. It really does look as though there is no fixed, non-changeable upper limit to life span. Replacing damaged organs to greatly extend the human lifespan by substituting young and healthy for old and failing is no longer science fiction. If trends in increasing life expectancy are sustained or accelerated by medical breakthroughs, then it certainly seems plausible to speculate that somebody alive today might indeed still be living in 2159."

The Path to Synthetic Organs (March 05 2009)
Yet another path towards replacement - or even additional, completely novel - organs is examined at EurekAlert!: researchers "have assembled different types of genetically engineered cells into synthetic microtissues that can perform functions such as secreting and responding to hormones, promising more complex biological capabilities than a single cell alone could produce. ... This is like another level of hierarchical complexity for synthetic biology. People used to think of the cell as the fundamental unit. But the truth is that there are collections of cells that can do things that no individual cell could ever be programmed to do. We are trying to achieve the properties of organs now, though not yet organisms. While the synthetic tissues today comprise only a handful of cells, they could eventually be scaled up to make artificial organs that could help scientists understand the interactions among cells in the body and might some day substitute for human organs. In principal, we might be able to build a stem cell niche from scratch using our techniques, and then study those very well defined structures in controlled environments."

Dopamine Neurons From iPS Cells (March 05 2009)
Via EurekAlert!: "researchers have developed a novel method to remove potential cancer-causing genes during the reprogramming of skin cells from Parkinson's disease patients into an embryonic-stem-cell-like state.
Scientists then used the resulting induced pluripotent stem (iPS) cells to derive dopamine-producing neurons, the cell type that degenerates in Parkinson's disease patients. This marks the first time researchers have generated human iPS cells that have maintained their embryonic stem-cell-like properties after the removal of reprogramming genes. Until this point, it was not completely clear that when you take out the reprogramming genes from human cells, the reprogrammed cells would actually maintain the iPS state and be self-perpetuating. Because [dopamine neurons] reside in the patients' brains, researchers cannot easily access them to investigate how the disease progresses at the cellular level, what kills the cells, or what might prevent cellular damage. Therefore, the ability to create patient-specific iPS cells, derive the dopamine-producing cells, and study those patient-specific cells in the lab could be a great advantage for Parkinson's disease researchers."

The Importance of the Stem Cell Environment (March 04 2009)
Research indicates that a future path for stem cell therapies might involve manipulating the cells' immediate environment in ways that reprogram those cells in specific, controllable ways: "We found that adult human mammary stem and progenitor cells exhibit impressive plasticity in response to hundreds of unique combinatorial microenvironments. Our results further suggest that rational modulation of the microenvironmental milieu can impose specific differentiation phenotypes on normal stem or progenitor cells, and perhaps even [restore cancerous cells to normal behavior]. All of this points to the rational manipulation of adult stem and progenitor cells as a promising pathway for beneficial therapies. Working with unique microenvironment microarrays (MEArrays) [we] can use combinations of proteins from a select tissue to create multiple microenvironments on a single chip about two square centimeters in area. These results are exciting because they indicate that we can test a large number of effectors and determine which ones to use to direct the fate of adult stem and progenitor cells. This give hope that one day - sooner rather than later - the information could be used for therapy."

Another Media Article on Intermittent Fasting (March 03 2009)
The health benefits of intermittent fasting - practiced as a form of calorie restriction - seem to be the flavor of the week. Here's an article from the Independent: "a mounting body of evidence is hinting strongly at the therapeutic value of intermittent fasting - of taking the occasionally day - weekly or monthly, perhaps - off food altogether. Much of that evidence comes from [a] 'quite large body of results' from animal studies.
Mattson explains that in laboratory tests, rats and mice on fasting diets tend to live longer, develop fewer cancers and show reduced cognitive decline in aging compared with animals with continuous access to food. A few recent human studies seem to back up the view that intermittent fasting, and calorie restriction more generally, are fertile areas for healthcare research. Studies on animals suggest this is a protective response. At a cellular level, the dearth of food prompts a mild stress reaction. We've seen this with brain cells and also liver and heart cells. Mild stress prompts an increase in production of stress-resistant proteins. Thanks to almost universally encouraging results from animal studies, several are already under way or in the pipeline. It's not inconceivable that in the next few years doctors will be recommending intermittent fasting in the same breath as five-a-day and regular exercise."

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