Longevity “Fast” Track

Healthy Life Extension

Funding Aging Research

Longevity "Fast" Track

posted on November 8th, 2011

Dear Future Centenarian,

Have you explored the values of fasting?

We see pros and cons about extended fasts, but most knowledgeable health experts agree that skipping meals or fasting gives your digestive system a rest and helps detoxify your system if your diet is unhealthy. If you are a carbohydrate nutritional type who fares better with a high complex carbohydrate diet, you might do better with fasting than a protein nutritional type who functions better with a lot of protein.

Maybe the best argument for fasting is, our ancestors did not eat regular meals like we do today. They ate when they killed or found food and when they had some stored food left over. Extended periods between meals was normal. Our bodies are still programmed to miss meals. That™s one reason you should break up your regular meal schedule or grazing with some type of intermittent fasting.

Fasting also helps, because what you eat, drink and breathe all have the potential to increase your toxic load. Ditto for what you put on your skin. Even though your lungs, liver, kidneys and your skin are designed to remove your toxins, they are stretched beyond their limits in today™s polluted world. So it™s up to you to periodically cleanse your system if you want to keep toxins from prematurely aging you and making you sick.

If you™re average, you may be carrying around putrefying sludge in your colon. Some carry pounds of it. Get rid of it. It is aging you before your time by reducing your body™s ability to absorb nutrients. It also makes you sick by dumping its rotting by-products into your system. You can do this by fasting.

Fasting is simple and easy. I recommend short fasts, two to four days every month. Or you might try two days every two weeks or one day every week. Drink only filtered water or distilled water and bone broth. For even better results, you might drink two to three large mugs of hot filtered water each fast day with two tablespoons of raw apple cider vinegar and one teaspoon of raw honey.

You can get the beneficial effects of caloric restriction (CR) if you eat as much as you want every other day and fast every other day. Besides being the only proven way to extend maximum lifespans in mammals, CR is also an effective way to dodge diabetes, heart disease and nearly every other disease associated with aging.

Another form of fasting is going on a CR 7 eating schedule. What does this mean? It means you utilize a concept called œintermittent fasting to redistribute and lose body fat and to simulate caloric restriction. Do not eat past 6 PM and do not eat before 11 AM.  By doing so, you go on a 17 hour fast every day. According to a 2005 article in Lancet, mice and rats maintained on an intermittent fasting regimen lived up to 30% longer than those fed otherwise.

Combine fasting with a pure diet coupled with regular exercise to remove toxins from your body and to keep them from accumulating in the first place.

Long Life,
David Kekich


RESEARCH ON BACTERIAL AGING Friday, November  4, 2011 http://www.fightaging.org/archives/2011/11/research-on-bacterial-aging.php
The aging of bacteria grants us insight into the very earliest evolutionary origins of aging: "When a bacterial cell divides into two daughter cells and those two cells divide into four more daughters, then 8, then 16 and so on, the result, biologists have long assumed, is an eternally youthful population of bacteria. Bacteria, in other words, don't age - at least not in the same way all other organisms do. [But] not only do bacteria age, but [their] ability to age allows bacteria to improve the evolutionary fitness of their population by diversifying their reproductive investment between older and more youthful daughters.

Aging in organisms is often caused by the accumulation of non-genetic damage, such as proteins that become oxidized over time. So for a single celled organism that has acquired damage that cannot be repaired, which of the two alternatives is better - to split the cellular damage in equal amounts between the two daughters or to give one daughter all of the damage and the other none? Bacteria appear to give more of the cellular damage to one daughter, the one that has 'aged,' and less to the other, which the biologists term 'rejuvenation'. In a bacterial population, aging and rejuvenation goes on simultaneously, so depending on how you measure it, you can be misled to believe that there is no aging. We ran computer models and found that giving one daughter more the damage and the other less always wins from an evolutionary perspective. It's analogous to diversifying your portfolio."

PGC-1 AND FLY LONGEVITY Thursday, November  3, 2011 http://www.fightaging.org/archives/2011/11/pgc-1-and-fly-longevity.php
PCG-1 is known to be connected to the benefits of calorie restriction in a range of species, and here researchers are working with flies:
"One of the few reliable ways to extend an organism's lifespan, be it a fruit fly or a mouse, is to restrict calorie intake. Now, a new study in fruit flies is helping to explain why such minimal diets are linked to longevity and offering clues to the effects of aging on stem cell behavior. Scientists [found] that tweaking a gene known as PGC-1, which is also found in human DNA, in the intestinal stem cells of fruit flies delayed the aging of their intestine and extended their lifespan by as much as 50 percent.

While little is known about the biological mechanisms underlying this phenomenon, studies have shown that the cells of calorie-restricted animals have greater numbers of energy-generating structures known as mitochondria. In mammals and flies, the PGC-1 gene regulates the number of these cellular power plants, which convert sugars and fats from food into the energy for cellular functions. The researchers found that boosting the activity of dPGC-1, the fruit fly version of the gene, resulted in greater numbers of mitochondria and more energy-production in flies - the same phenomenon seen in organisms on calorie restricted diets. When the activity of the gene was accelerated in stem and progenitor cells of the intestine, which serve to replenish intestinal tissues, these cellular changes correspond with better health and longer lifespan."

DEDIFFERENTIATION AND STEM CELL TRANSPLANT EFFECTIVENESS Thursday, November  3, 2011 http://www.fightaging.org/archives/2011/11/dedifferentiation-and-stem-cell-transplant-effectiveness.php
Via EurekAlert!: "Research into differentiation has led to a variety of breakthroughs as stem cell researchers harvest cells from one part of the body and genetically adapt them to fulfill a specialized role. However, if the implanted cells are too much like the cells of the targeted area they may not have the plasticity to engraft and repair the injured tissue. ... Stem cell differentiation and transplantation has been shown to improve function in conditions including degenerative diseases and blood supply disorders. However, the survival rate of transplanted cells in patients limits their overall effectiveness, which is a barrier to clinical use.

To overcome this issue [researchers] explored de-differentiation, a process that reverts specialized, differentiated cells back to a more primitive cell. The team focused their research on multipotent stem cells, (MSCs) which can be altered into a variety of cell types through differentiation. Bone marrow MSCs have the potential to differentiate into each of the three basic types of lineage cells which form bone (osteocytes), cartilage (chondrocytes) and fat tissue (adipocytes).The team first differentiated bone marrow MSCs towards a neuronal lineage, but then removed the differentiation conditions, allowing the cell to revert back to a form with more basic cellular characteristics. Following this process the team recorded increased cell survival rates following transplants. In an animal model de-differentiated cells were found to be more effective in improving cognitive functions and in aiding recovery from strokes, compared to un-manipulated stem cells both in living specimens and in laboratory experiments."

MORE DATA ON AGE AND STEM CELL TRANSPLANTATION Wednesday, November  2, 2011 http://www.fightaging.org/archives/2011/11/more-data-on-age-and-stem-cell-transplantation.php
Making therapies that can work in older patients despite their frailty and damage is an important part of progress in stem cell medicine of all sorts: "Age alone no longer should be considered a defining factor when determining whether an older patient with blood cancer is a candidate for stem cell transplantation. That's the conclusion of the first study summarizing long-term outcomes from a series of prospective clinical trials of patients age 60 and over.  The five-year rates of overall and disease-progression-free survival among mini-transplant patients were 35 percent and 32 percent, respectively.

Patients in three age groups - 60 to 64, 65 to 69 and 70 to 75 - had comparable survival rates, which suggested that age played a limited role in how patients tolerate the mini-transplant. Conventional transplants, which are generally not performed on people over age 60 or others who are medically unfit, use high doses of total-body irradiation and potent chemotherapy to eliminate leukemic cells. The intense treatment destroys the blood and immune system and is fatal unless the patient is rescued by infusion of donor bone marrow or stem cells isolated from peripheral blood. The mini-transplant, in contrast, relies on the ability of donor immune cells to target and destroy the cancer - without the need for high-dose chemotherapy and radiation. Instead, low-dose radiation and chemotherapy is used to suppress the immune system rather than destroy it. This helps the body accept the donor stem cells, which then go to work to attack cancer cells - called the graft-vs.-leukemia effect - and rebuild the immune system."

AGE DIMINISHING AS A BARRIER IN REGENERATIVE MEDICINE Tuesday, November  1, 2011 http://www.fightaging.org/archives/2011/11/age-diminishing-as-a-barrier-in-regenerative-medicine.php
Over the last few years there have been a series of positive developments in stem cell research that suggest the age of a patient will not be a significant hurdle in generating useful cells for therapeutic use. Here is another: "Researchers were able to successfully transform cells from patients as old as 100 into stem cells virtually identical to those found in embryos. If these can be used to grow healthy tissue which can safely be transplanted into elderly patients it could open up new avenues of treatment for the elderly.

This is a new paradigm for cell rejuvenation. The age of cells is definitely not a barrier to reprogramming. Scientists can use a method of taking normal cells from adults and reversing them to an unspecialized state, known as induced pluripotent stem cells (iPS), making them almost indistinguishable from embryonic stem cells. But experts are divided over whether the technique can work efficiently in elderly patients, who have the most to gain from the potential treatments, because their cells have deteriorated further. By adding two new ingredients, known as transcription factors, to the method of generating adult stem cells, they were able to overcome this hurdle and 'reset' many of the key markers of ageing in cells."

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