Health and Life Extension, Aging Research

Health and Life Extension

Funding Aging Research

Producing, Investing and Life Extension

posted on March 31, 2009

We™re going to cover the third rendition of Kekich™s Credo by Dr. Pete Hilgartner in this issue.

Credo #6. Produce for wealth creation and accumulation.  Invest profits for wealth preservation and growth.  Produce more than you consume and save a minimum of 20% of all earnings.  Pay yourself first.

From Dr. Pete:

Not only is this great financial advice, but with a little creativity, it can be directly applied to your health.

Here goes¦

Produce for wealth creation and accumulation.

As humans, we are producers and creators.  Every second of every day, we are producing new cells to replace old, used up cells.  We are producing energy that allows us to produce ideas, products, goods, and services.  We are producing amino acids that build muscles and other structures in the body.  We are also accumulating a reserve of energy and nutrient stores to be used at a later date or in times of stress.  (That is, as long as we are eating the right foods to produce the reserve.)

However, we also accumulate waste products.  We accumulate these waste products form the normal process of metabolism, but also from our exposure to the junk, chemicals, pesticides, preservatives and additives in our food and environment.  Good food, clean water and a fast or detox-cleanse every 3 months will help.

Think of the accumulation of nutrient stores as money in the bank and toxin and waste product stores as credit card debt.  Which one makes you feel more secure?  Which one is healthier for you?  Which one do you do?  A detox is like a huge payment toward your debt.  The more you do, the more stable your situation becomes.

You may be saying, œI know, I know¦ I™ve heard this before.  The question is, do you DO it.  If you DO it, you KNOW it.  If you don™t do it, you only know ABOUT it.

To use the rest of the statement¦

If you are investing profits for œhealth preservation and growth, you have to be doing the things in life that will actually produce a œhealth profit.

If you have read my book, The Secrets of How to Feel 20 Years Younger in 90 Days or Less, you know there are six things you need to regularly do in order to maximize your genetic potential for health.

You need to have a strategy that addresses your Structure, Nutrition, Exercise, Rest, Attitude and Energetics.  By taking action on this strategy, you are investing in health preservation and growth, just as if you invested a portion of your pay to accumulate wealth.

To apply the ˜produce more than you consume, and save a minimum of 20%of all earnings, look at energy intake and output.  Eat less than you burn.  Don™t take in more calories than you use. That™s not where you want to apply the ˜save 20%™ principle.

The save 20% piece can apply to the simple idea of setting aside specific time each day just for you.

Busy Moms can relate to this one.  Who always gets the short end of the stick?  Mom!  She is typically so busy taking care of everyone else that she puts herself last.

That™s the wrong answer.  Be a little selfish.  Maybe you take 30 minutes every morning before everyone is up, to walk or meditate or read. It could be that you take an hour out of your busy week for a massage.
Maybe you take a few extra minutes to cut and prepare some fresh foods rather than the œCrap-in-a-tray you were thinking about eating.

The point is, Pay Yourself First!  Save that 20% for YOU.

Give from your abundance, not from your poverty.

If you are always producing, creating and giving to others before your self, that™s like spilling water out of a pitcher without refilling it. Eventually the pitcher runs dry. Then what happens?

That™s right, all hell breaks loose and the whole house of cards falls down.  Kinda like what™s happening all around us for those who have more debt than savings. The same principles apply to health.

Don™t let life foreclose on your body!


Thank you Dr. Pete, for your great insights and advice.


While our society is still only at the very base of the ladder of longevity technologies, we have a good view ahead as to what is possible in years to come. We know that we or our descendants can eventually cure aging completely, because we know that the machinery capable of that task is not forbidden by the laws of physics - and in fact many good examples already exist in the world around us.

"There's no law of physics that will prevent we clever humans - and our enhanced descendants - from eventually building technologies that can maintain and arrange every aspect of our bodies exactly as we'd like them to be. Technologies that can find every out of place molecule or damaged component and promptly fix it up. Aging will be a thing of the past in that era of molecular nanotechnology, whenever it comes to pass.

"Systems that can identify, manage and place trillions of molecules accurately are not a pipe dream; after all, we are already surrounded by examples. You, for example, are just such a system, albeit somewhat slow at self-assembly to full size. There's nothing in the laws of physics that jumps out and says we can't do this. It's just a matter of time.

"Our cells are already very impressive examples of adaptive machinery. The machines our descendants will build with the knowledge gained from today's study of biology will be even more impressive yet. Cells, for all their intricacy, are far less efficient and organized than the laws of physics permit. One day, that inefficiency and disorganization will be eliminated by machinery intended to augment or replace our cells, and everyone will be the better for it."


Heat Shock Proteins and Cancer Immunotherapy (March 27 2009)
One of the roles of heat shock proteins such as Hsp70 is to carry other proteins around a cell - for example, when they are damaged or misplaced and need to be broken down in a lysosome. This paper shows that if you hook out heat shock proteins from cancer cells, they come attached to all sorts of biochemicals that can be used to train the immune system to kill those cancer cells: "In the present investigation, we have demonstrated that immunization with tumor cell derived Hsp70 lead to an effective survival advantage in mice with minimal residual tumor cells from which Hsp70 is derived, by involvement of immune cell types in the rejection of tumors. It has been observed that autologous Hsp70 induces specific anti-tumor immunity and effectively eradicates tumors in the host mice, thereby enhancing survival of tumor-bearing host. Furthermore, Hsp70 immunized mice did not show any systemic disorder. Therefore, it could be assumed as safe and might be clinically useful for vaccination against malignant human tumors."

Improved Induced Pluripotency (March 27 2009)
Researchers continue to move rapidly in advancing the state of the art in induced pluripotent stem cells: "A team of scientists has advanced stem cell research by finding a way to endow human skin cells with embryonic stem cell-like properties without inserting potentially problematic new genes into their DNA. This is not the first time that scientists have endowed differentiated cells like skin cells with the capacity to develop into any of the roughly 220 types of cells in the body, a process known as induced pluripotency. But it is the first time that they have done so without using viruses, which can insert potentially harmful genes into the cells' genetic material and trigger cancer. [The] new method imports the necessary genes on a small circle of DNA known as a plasmid. Over time, the plasmid disappears naturally from the cell population, avoiding the danger posed by using viruses. Scientists view pluripotent cells as invaluable to studies of normal and disease processes and to understanding the effects of certain drugs. In the future, doctors might be able to use such cells therapeutically to replace those affected by diseases such as Alzheimer's and Parkinson's or lost to traumatic injuries."

More on the Value of Exercise (March 26 2009)
Level of exercise beginning in middle age and mortality rate are very well correlated, as shown by this study: "Despite the known hazards of physical inactivity, it continues to be a major health problem. Physical inactivity is associated with increased incidence rates of obesity, diabetes, cardiovascular diseases, osteoporosis, and cancer. The absolute mortality rate was 27.1, 23.6, and 18.4 per 1000 person years in the groups with low, medium, and high physical activity, respectively. The relative rate reduction attributable to high physical activity was 32% for low and 22% for medium physical activity. Increased physical activity in middle age is eventually followed by a reduction in mortality to the same level as seen among men with constantly high physical activity. This reduction is comparable with that associated with smoking cessation." To restate that last point: lazing around and skipping over a little exercise every day costs you as much healthy life in the long run as smoking does.

Immunized Against Cancer? (March 26 2009)
From ScienceDaily: "New research suggests that monoclonal antibody therapy of cancer can be improved to be much more powerful than it is today. We believe that antibody therapy has the capacity to immunize people against cancer. Treatment modifications might be able to prolong, amplify, and shape a continuous immune response to cancer cells. Scientists now believe that it will be possible to alter the antibodies so that they induce both kinds of human immunity - the innate immune response that is short-lasting and which directly kills tumor cells, and a long-lasting 'memory' response that comes from the adaptive immune response. We have long thought that monoclonal antibodies are capable of stimulating the innate immune system, but we now have evidence that the therapy can prime an adaptive response as well. Such responses would make the treatment much more powerful, capable of keeping cancer under control."

On Longevity Gene Networks (March 24 2009)
Our genes of metabolism interact in a very complex and dynamic fashion, and some aspects of that interaction determine longevity. Efforts to pick apart this tangled web require equally complex tools of analysis: "The genome era and the advent of high-throughput technologies have brought about a huge increase in the amount of data available to biologists: each genome contains tens of thousands of genes, whose products can potentially interact with each other in an astronomical number of ways. This quantitative change has created a need for a qualitative change in the way we perform analyses: the human brain is not very good at understanding thousands of things at once, let alone millions or billions, so we must find new ways to extract comprehensible patterns from torrents of data. Many of the techniques being developed to analyze large biological networks fall under the umbrella of systems biology. Some of the newest tools have been used guide genetic perturbation studies in yeast, resulting in the discovery of novel lifespan control genes. What can such network analysis tell us about human aging?" The enormous complexity of metabolism-determined longevity is yet another argument for focusing on repair of already identified damage to reverse aging, rather than trying to manipulate this tangled system to slow aging.

What is Transhumanism? (March 24 2009)
Via the Exception: "The doubling rate of medical knowledge is three years - that is, the next three years of medical research will yield as much knowledge as has been yielded in all of human history. The next three years will double our knowledge again, and again, and so on. This exponential growth in knowledge will rapidly enable us to eradicate disease and radically improve the human condition. Indeed, we will be able to look beyond curing the sick, towards a future in which we make ourselves more than healthy. We will be able to enhance our memory and our intellectual capacity. We will use technology to make ourselves faster, more efficient, and radically longer-lived. We will be able to augment our physical strength, stamina, and resistance to disease. We might enhance specific skills, such as visual acuity or musical talent. In the extreme, we will correct the molecular wear-and-tear that causes deterioration and death “ reversing the aging process itself. Humans might even obtain entirely new capacities, such as infrared vision, or bat-like echolocation. The body of thought that deals with enhancement technologies is called transhumanism. In essence, transhumanists favor using technology to enhance mental and physical human capacities."

Bivalves in Aging Research (March 23 2009)
You might recall that some species of clam live for as long as four centuries, and possibly longer. Others do not. Such differences between closely related species are an opportunity for researchers to uncover important mechanisms of longevity. From Ouroboros: "This invertebrate group includes species with the longest metazoan lifespan approaching 400 y, as well as species of swimming and sessile lifestyles that live just for 1 y. Bivalves from natural populations can be aged by shell growth bands formed at regular intervals of time. Extreme longevity of some bivalve models may help to analyze general metabolic strategies thought to be life prolonging, like the transient depression of metabolism, which forms part of natural behaviour in these species. One of the great advantages of bivalves is their variety: even though they're anatomically quite similar, they occupy a wide range of niches and consequently exhibit a large variation in aspects of their natural histories, including longevity. This makes clams and oysters excellent candidates for comparative biogerontology: studying organisms with basically identical body plans but wildly different lifespans allows us to focus more tightly on the features (molecular, cellular, systemic) that might explain the change in longevity. This theme is currently being developed - outside the mollusk community - into a large-scale project that will study dozens of species in four or five vertebrate clades."

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