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35 Dynamic Years :)… then 35 in a Char :(

Healthy Life Extension

Funding Aging Research

First AI Proof of Concept for Aging Completed

Dear Future Centenarian, 

A KEY aging culprit is finally addressed by advanced technology.

As we age, it turns against our bodies. It creates the plaques in our arteries which can lead to heart attacks and strokes. It damages DNA, and can turn healthy cells into cancers. In cartilage, it™s the proximate cause of arthritis. In fact¦

TIME Magazine calls it œThe Secret Killer.

It can destroy you¦ without your awareness. Time also calls it the surprising link to HEART ATTACKS, CANCER, ALZHEIMER™S and other diseases.

The Cleveland Clinic says: "Although it is essential to know your cholesterol levels, the actual cause of heart attack, stroke or death is (It).

And it really kicks in as we grow older. Besides killing us, it can cause¦

  • Low energy
  • Aches and pain
  • Accelerated aging
  • Allergies and hay fever
  • Decreased sex drive
  • Skin disorders like eczema

The œIT in this case is INFLAMMATION. And it is shrouded in mystery, misinformation, misconceptions, and, it is, if the experts quoted above truly know their stuff, UNDERESTIMATED as a huge contributor to aging, dying and pain.

I™ll get back to inflammation, but first allow me to digress to another and even bigger topic¦and for a good reason.

It™s no secret that my favorite technology to accelerate life extension research is Artificial Intelligence (AI). Specifically Artificial General Intelligence (AGI). AGI technology will allow computers to learn, think and respond like humans.

Few realize that virtually every phase of our lives is already impacted and dependent on AI.

And even fewer realize that the lack of AI has kept biology in the dark ages compared to other fields.

But biology is simply too complex to be solved without increasingly powerful tools. AGI is such a tool.

Imagine this¦ a Ph.D. lab assistantthat would have total recall and tirelessly work around the clock. It would be able to download all the data it needs from the Internet almost instantaneously. It could collaborate with humans and other AGI. And then, it could be quickly copied as many times as necessary.

Imagine unleashing 100,000 AGI researchers. Imagine how much faster they would develop real anti-aging therapies. This is in our future.

But we don't need full-scale AGI to make an impact on aging.

œWe have just done it.

Here is why my digression was an important one. We have crafted something unexpectedly simple, yet one that can have a profound effect on that Silent Killer.

See, the first of several nutritional supplements developed entirely by AI addresses perhaps the single biggest threat to our wellness and longevity “ chronic inflammation.
Lowering your chronic inflammation is one of the most effective overall wellness and anti-aging strategies on the planet for you to learn.

What is most exciting about this Inflammation/AI connection is that you can now put your genes to work for you.

For the first time, AI technology has isolated the genes involved in inflammation.  Next, AI was used to determine how to control these genes with networks of natural compounds. 

With traditional nutraceutical discovery, largely based upon œtrial and error, this would never have been possible.

For this supplement, AI algorithms were used to match thousands of herbal extracts against those newly discovered genetic networks that contribute to inflammation.

Next, developers put together the most effective herbal network to plant into the body™s genetic command system to counteract the ill effects of inflammation in those affected.

The result? InflammExâ„¢: a strategically designed nutritional supplement for anti-inflammatory support. It combines the technology of AI with the full-spectrum of whole herbs in their natural state.

It officially goes on sale today, and you are among the first to be alerted.

Please go to now to see more.

More Life,
David Kekich

P.S. Here™s an entertaining 86 second video by Greta Blackburn which gets right to the heart of the matter. 

Latest Headlines from Fight Aging!

Proposing to Print a New Heart Within a Decade - Monday, November 25, 2013
Researchers are becoming more comfortable putting forward timelines for organ printing, which we might take as a sign of progress in and of itself.

Read More

A Perspective on Coming to Support Longevity Science - Monday, November 25, 2013
The most important aspect of our era by far is the prospect for greatly extending healthy life through new medical technology. Long after everything else is forgotten, these years will be remembered as the end of degenerative aging.

The new biotechnologies of rejuvenation will only happen rapidly enough to benefit those of use in mid-life if greater funding and attention is given to the best lines of research, however. This is the most important age of mankind, but we ourselves will not greatly benefit from it unless we help move things along more rapidly.

When you are deeply involved in advocacy for longevity science, it is easy to lose your memory of not caring and not knowing. Once upon a time we were all either ignorant or opposed to living longer, as most of the world remains at this time.

Read More

Growing Artificial Skin From Umbilical Cord Cells - Tuesday, November 26, 2013
Here is news of one of a number of approaches to building bioartificial skin. As for many organs, a replacement doesn't have to be exactly the same as natural tissue. Rather it just has to be capable of at least some of the functions provided by natural tissue in order to be both beneficial and useful.

Read More

Cellular Senescence in Aging as Adapted Tool of Development - Tuesday, November 26, 2013
An accumulation of senescent cells is one of the causes of degenerative aging. These are damaged or otherwise dysfunctional cells than stop dividing and start issuing signals that are disruptive to surrounding tissues.

They should be destroyed by their own programs or by the immune system, but nonetheless accumulate over time, their presence becoming increasingly harmful. Cellular senescence is thought to be a defense against cancer, and as is also the case for the shutting down of stem cell activities with age, this is a defense that bears its cost in terms of increased frailty and tissue failure.

Here researchers argue that the increasing presence of cell senescence with age is a late-life adoption of a mechanism that evolved to steer embryonic development.

Read More

Regular Exercise Correlates With Better Long Term Health - Wednesday, November 27, 2013
Here is a study that provides more data to strengthen the already well-proven correlation between regular exercise and long-term health.

Read More

A Review of Natural Mechanisms for Removing Tau - Wednesday, November 27, 2013
Like the better known amyloid-beta, the protein tau accumulates in Alzheimer's disease, and there is still much debate over exactly how this relates to damage and dysfunction.

A fair portion of Alzheimer's research now focuses on clearance of amyloid and tau, often through immune therapies. We can hope that this produces technology platforms that can be turned to the removal of other forms of amyloid and unwanted proteins known to build up in old tissue. Here is an open access review that looks over what is presently known of the existing natural mechanisms that work to clear tau.

Read More

Ray Kurzweil and Radical Life Extension - Thursday, November 28, 2013
I have long found it curious that Ray Kurzweil's public position on radical life extension omits support of specific ongoing research aimed at producing therapies for aging, such as the SENS program of rejuvenation biotechnology.

This may be because he prefers to think in terms of broader trends rather than try to pick winners from present initiatives. Alternatively it may be because he sees the machine phase of medicine - the use of swarms of nanorobots capable of maintaining or replacing our biology - as emerging sooner rather than later.

As for me, I don't think that an early arrival of machine phase medicine is plausible: from where I stand it looks as though the medicine of the next four decades will be almost entirely based on control and manipulation of cells, alongside the design of proteins that complement our existing evolved set of protein machinery. We will augment and direct our own molecular biology using more molecular biology for decades before we get to the point of designing and using nanomachines that are as complex as cells without being biological at all.

So programs that are logical outgrowths of present day medicine - like SENS, pushing for repair therapies for cells and clearance of waste products - are the next step in human longevity. It's not a matter of skipping straight to nanorobotic cell replacements of the sort envisaged by Robert Freitas and others.

Read More

Multiple Methods of Regeneration in Similar Salamander Species -Thursday, November 28, 2013
Researchers have for some years been investigating the mechanisms by which salamanders can regenerate limbs and organs. The hope is that either this capacity still exists in mammals in some form, dormant but able to be reactivated, or otherwise that there is something to be learned from salamander biology that might be imported to mammals to create greater feats of regeneration.
This latest research might go some way to explaining some of the contradictory results that have emerged from past work on the biology of salamander regeneration, such as whether or not their regenerative capacity declines with age.

Read More

Correlations With Species Longevity Found in the Lipidome - Friday, November 29, 2013
The membrane pacemaker hypothesis suggests that one of the most important links between biology and longevity is the composition of cell and organelle membranes.

If membranes are more resistant to oxidative damage then the result will be greater longevity. Differing levels of resistance can emerge in different species because of differing proportions of various lipids that make up membrane structures: some lipids are less vulnerable to peroxidation than others. Here, researchers demonstrate a good correlation between lipid profiles and longevity.

Read More

A Look at Lipid Replacement Therapy - Friday, November 29, 2013
There has been more interest of late in how to engineer ways to sneak useful proteins past the digestive system so that they can be added to the diet but still find their way into cells.

Researchers here combine this with the idea that you can dilute the proportion of damaged lipids present in cell membranes by providing a patient with a supply of undamaged lipids, larger than the body would otherwise generate on its own. I am not familiar enough with this line of work to be able to comment on how useful it is in practice, or whether the balance of evidence suggests that the observed results in trials actually occur due to the replacement of damaged lipids, as the authors state below. It is nonetheless quite interesting in the context of the membrane pacemaker hypothesis.

Read More

DISCLAIMER:  News summaries are reported by third parties, and there is no guarantee of accuracy. This newsletter is not meant to substitute for your personal due diligence and is not to be taken as medical advice. For originating report, please see

David A. Kekich
Maximum Life Foundation

"Where Biotech, Infotech and Nanotech
     Meet to Reverse Aging by 2033"


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