Longevity News Digest

Funding Aging Research

Discovery Illuminates Your Path to Healthiest Longevity

Dear Future Centenarian,

We have known for a long time how important eating habits and exercise are to wellness and longevity.


It took an evolutionary biologist™s 30 year research project to discover just HOW important¦ and more importantly¦ the most impactful TYPE of diet and exercise.

Dr. Michael Rose, at the University of California at Irvine, selectively bred fruit flies for longevity for over 30 years. Today, his animals live an astounding FOUR times longer than their not-so-lucky cohorts. They act young all that time too. He then determined the genetic differences between his flies and their mere mortal cousins.

Surprisingly, Dr. Rose™s animals™ longevity genes are about 90% common to humans™. While analyzing those genes, he had a œeureka experience. In a flash, he hypothesized how to mimic the evolutionary basis for human longevity through diet and exercise. He discovered what evolution teaches us about how to age without aging.

It boils down to two simple habits.

Mother Nature is not our friend much longer after reproduction age. We™re dispensable with few built-in mechanisms to counteract aging-related diseases. Worse, modern diets and lack of, or wrong types of exercise, accelerate our decline and encourage heart disease, cancer and more.

Factoring in chronic stress, no wonder the average person dies at least ten years prematurely¦ and suffers and declines unnecessarily our last 7-8 years.

So what™s the simple key to keeping vibrant about 17 years longer than your neighbors?

Just this: According to Dr. Rose, all you need is getting back to basics. Live eat and exercise as closely as you can to the way your ancestors did.

And I don™t mean your great grandparents. We™re talking Stone Age. Long before the agriculture age “ starting 10,000 years ago. Ironically, farming and commercial food production which made it possible for civilization to flourish, led to most of the diseases we suffer from today.

Why? Because foods that dominate farming, notably grains, dairy and legumes, were not part of our ancestors™ regular diets.

So we are not genetically adapted to them yet. It takes much longer than the 5-10,000 years from the time humans started eating them, for us to genetically adapt. So our bodies start to rebel after age 40 or so, age prematurely, and start developing killer diseases. 

Following may be the most life-enhancing tips you have ever gotten:

Eliminate, or cut way back, all grains, dairy and legumes from your diet if you are over 40, and especially if you are over 50. Eat a wide variety of fresh veggies, fruits and nuts and some free-range animal products if you wish.

I know what you™re thinking. œThat would be too much of a sacrifice, and it would deprive you of a big chunk of life™s pleasures. That™s what I thought too, until I found how easy it is to find amazingly tasty substitutes. I™ve been on this path for almost five years now and have NEVER felt better.

Exercise like a caveman. They walked a lot, jogged some, sprinted and carried stuff¦ and got plenty of sleep. Their stress was the kind that promotes growth, not the chronic stress modern civilization heaps upon us. Exercise with interval training, and relax proactively.

Mimic your ancestors™ lifestyle to live, and live well, way beyond average lifespans.

To see how to make this and more easy for you, get your copy of Smart, Strong and Sexy at 100 at Amazon.com. Here™s your LINK.

More Life,
David Kekich

P.S. Watch this TED talk if you want to see just how powerful this strategy can be. https://www.youtube.com/watch?v=KLjgBLwH3Wc

Latest Headlines from Fight Aging!

A Measure of Declining Cancer Mortality Rates – Monday, January 5, 2015
A combination of advances in medicine and a decline in smoking are reducing the mortality rates due to cancer.

The effect of smoking is large because so many people do it and it is an effective road to the development of lung cancer. It is worth noting that the decrease in cancer mortality rates is in a time when the demographic profile of the population is shifting to include a larger number of older people with a greater risk of suffering cancer, as well as a concurrent rise in the number of overweight and obese individuals, a condition that is also associated with increased risk of suffering many cancers.

Read More https://www.fightaging.org/archives/2015/01/a-measure-of-declining-cancer-mortality-rates.php

Considering Sarcopenia – Monday, January 5, 2015
A post on age-related loss of muscle mass and strength can be found at the Science of Aging blog of the Buck Institute for Research on Aging.

Read More https://www.fightaging.org/archives/2015/01/considering-sarcopenia.php

A Review of What is Known of MicroRNAs in Aging – Tuesday, January 6, 2015
MicroRNA (miRNA) molecules play a complex and quite indirect role in the process of producing proteins from genetic blueprints, their activities adjusting the amount of protein produced for a range of genes.

Since protein levels change in aging, we should expect to also see changes in miRNAs also. The system reacts to the cellular and molecular damage that causes aging, and this is another part of the reaction.

Read More https://www.fightaging.org/archives/2015/01/a-review-of-what-is-known-of-micrornas-in-aging.php

Are Lysosomes Influencing Longevity Through Mechanisms Other than Garbage Collection? – Tuesday, January 6, 2015
Lysosomes within cells recycle cellular waste and damaged cellular structures, ingesting them and then breaking them down with a range of enzymes.

Over time, however, lysosomes in long-lived cells such as those of the central nervous system become bloated with a buildup of comparatively rare waste products that they cannot recycle and their functional activity declines.

This certainly has a serious impact on the ability of an older cell to function, but is this only because of the growing level of unrecycled garbage in the cell? Researchers here uncover another way in which lysosomes are influencing longevity in a lower animal, and it will be interesting to see if comparable mechanisms also operate in mammals.

Read More https://www.fightaging.org/archives/2015/01/are-lysosomes-influencing-longevity-through-mechanisms-other-than-garbage-collection.php

A Historical Correlation Between Solar Activity at Birth and Consequent Life Expectancy – Wednesday, January 7, 2015
It has been suggested that greater levels of solar radiation may reduce life expectancy by raising the likelihood of damage during embryonic and later development, and researchers have in the past mined historical data in search of correlations.

At this point discussion of possible mechanisms is still quite speculative, however. Here is another example of this line of research.

Read More https://www.fightaging.org/archives/2015/01/a-historical-correlation-between-solar-activity-at-birth-and-consequent-life-expectancy.php

Stem Cell Depletion Does Not Accelerate Muscle Loss in Aging – Wednesday, January 7, 2015
Researchers aiming to produce a mouse model of accelerated sarcopenia, the characteristic loss of muscle mass and strength that occurs with aging, instead found that depleting muscle stem cell populations had no effect on this condition.

This implies that the loss of stem cell activity in muscle tissue associated with aging may not be all that important in the development of sarcopenia after all.

Read More https://www.fightaging.org/archives/2015/01/stem-cell-depletion-does-not-accelerate-muscle-loss-in-aging.php

Measures of Function are Maintained to a Greater Degree Over Time in Fit People – Thursday, January 8, 2015
Here is a study that gives some idea of the degree to which the majority of people who do not maintain a good level of fitness are harming themselves over the years.

Read More https://www.fightaging.org/archives/2015/01/measures-of-function-are-maintained-to-a-greater-degree-over-time-in-fit-people.php

A Less Dysregulated Immune System is Associated With Better Cognitive Function in Aging – Thursday, January 8, 2015
The adaptive immune system declines with age for reasons that are partially structural. The slow rate of production of new immune cells in adults and the pace of turnover results in an effective cap on the number of these cells present at any one time.

Immune cells are devoted to remembering threats as they occur, but some otherwise largely innocuous and widespread pathogens like cytomegalovirus cannot be effectively cleared from the body. Ever more memory T cells are devoted to that particular topic over the years, and this leaves ever less space for naive T cells capable of destroying invading pathogens.

So to a first approximation the more memory cells you have in old age the worse off you are. Here is a correlation between that measure of immune system dysregulation and age-related declines in cognitive function.

We can speculate that linking mechanisms might include the chronic inflammation that accompanies age-related immune system dsyfunction or a decline in aspects of the supporting role played by portions of the immune system that are specific to brain tissue.

Read More https://www.fightaging.org/archives/2015/01/a-less-dysregulated-immune-system-is-associated-with-better-cognitive-function-in-aging.php

More Work on Engineering New Intestinal Tissue – Friday, January 9, 2015
A number of research groups are working towards growing intestinal tissue, but this area of the field of tissue engineering is still at the exploratory stage, with no-one much past the level of creating small sections of usefully structured tissue.

Getting the structure right is one of the challenging parts of tissue engineering; every organ is different and requires the development of its own particular recipe and methodology.

Read More https://www.fightaging.org/archives/2015/01/more-work-on-engineering-new-intestinal-tissue.php

Senescent Cells and Detrimental Remodeling of Aged Lungs – Friday, January 9, 2015
Senescent cells accumulate with age. Transition into a senescent state is, at least initially, a defense against cancer in which cells that are damaged or likely to become damaged due to a dysregulated tissue environment permanently suppress their ability to divide.

Many destroy themselves or are destroyed by the immune system, but all too many of them linger on intact. In old skin a large portion of tissue is made up of senescent cells, for example.

Cellular senescence as a cancer defense is likely an adaptation of a tool used to shape tissue growth during embryonic development, which might explain why senescent cells secrete a range of molecules that cause harm to surrounding extracellular matrix structures and negatively impact the behavior of nearby cells.

The more senescent cells you have the more their presence degrades the function of tissues and organs. Eventually a large enough number of senescent cells and their secreted signals tip over from being protective against cancer due to removing the ability for damaged cells to replicate to a state of promoting cancer by creating inflammation and other harms in tissue.

The best solution to all of this is periodic clearance of senescent cells via some form of targeted cell killing technology, such as those under development in the cancer research community. That approach, like most related to repairing the causes of aging, receives comparatively little attention and funding, however. Here is another of the many examples of the damage done to a particular organ by growing numbers of senescent cells.

Read More https://www.fightaging.org/archives/2015/01/senescent-cells-and-detrimental-remodeling-of-aged-lungs.php

DISCLAIMER:  News summaries are reported by third parties, and there is no guarantee of accuracy. This newsletter is not meant to substitute for your personal due diligence and is not to be taken as medical advice. For originating report, please see www.fightaging.org/

David A. Kekich
Maximum Life Foundation

“Where Biotech, Infotech and Nanotech
Meet to Reverse Aging by 2033″