It’s Even Better Than We Thought

Healthy Life Extension

Funding Aging Research

It's Even Better Than We Thought

posted on December 20th, 2011

Dear Future Centenarian,

In a previous issue, I profiled a new anti-aging nutraceutical called Stem Cell 100 which had some impressive science behind it. It acts at the cellular level to revitalize your body™s own regenerative stem cells, which tend to lose function with age. This can help you feel better, look younger and improve your overall health. 

In my last report on Stem Cell 100, I wrote about the exciting experiments showing that it could double the maximum lifespan of an animal model. Now, more recent experiments show that even when Stem Cell 100 is added at midlife when 40% of the test animals had already died, the remaining 60% of animals could still double their maximum lifespan. This astounded me.

Moreover, within a few days of treatment at midlife, all-cause mortality dropped precipitously and remained low until maximum lifespan was reached. The dramatic lowering of all-cause mortality has not been previously observed with any genetic, small molecule, or dietary restriction treatment. Effects on stem cells, telomere support, and inhibition of mTOR are thought to be the main mechanisms responsible for these dramatic effects on lifespan by Stem Cell 100.

It is well known that stress is one of the persistent factors in our fast moving culture that can promote disease and shorten life. 

The supplement was tested in an animal model for its effects on stress resistance. These experiments show it provides potent resistance to stress, and treatment with Stem Cell 100 allows the animals to survive some 3 times longer under extreme stress. 

Fertility with and without Stem Cell 100 was also tested as a function of age. Young animals had virtually identical fertility with or without treatment. But the untreated animals lost much of their fertility with age, whereas treated animals retained high levels of fertility well past the point where most of the untreated animals had died.  Treated animals also appear more vigorous throughout life. Unlike the case with most longevity treatments, Stem Cell 100 treated animals thus appear to gain enhanced fitness and vitality.

Benefits include support for: 

- Healthy cardiovascular system 
- Healthy blood glucose, cholesterol and blood pressure for those already in the normal range 
- Younger looking skin 
- Improved focus and learning 
- Increased endurance
- Enhanced resistance to stress 
- Healthy immune system 
- Healthy colon, breasts, pancreas, and prostate 
I love this product. For more information, go to

Long Life,
David Kekich


One of the ways in which general health practices - such as exercise and fitness - steer cognitive health is through the state of the blood vessels in your brain: if they are deteriorating more rapidly, then more microinfarcts will occur, destroying more of the function of the brain, one tiny piece at a time. This is a mechanism quite distinct from the root causes of dementias like Alzheimer's disease, as this study illustrates: "This study was untaken to investigate the association of micro brain infarcts (MBIs) with antemortem global cognitive function (CF).

Subjects were 436 well-characterized male decedents from the Honolulu Asia Aging Autopsy Study. Brain pathology was ascertained with standardized methods, CF was measured by the Cognitive Abilities Screening Instrument, and data were analyzed using formal mediation analyses, adjusted for age at death, time between last CF measure and death, education, and head size. Based on antemortem diagnoses, demented and nondemented subjects were examined together and separately. In those with no dementia, MBIs were strongly associated with the last antemortem CF score. This suggests that microinfarct pathology is a significant and independent factor contributing to brain atrophy and cognitive impairment, particularly before dementia is clinically evident. The role of vascular damage as initiator, stimulator, or additive contributor to neurodegeneration may differ depending on when in the trajectory toward dementia the lesions develop."

NAYSAYERS ABOUND Friday, December 16, 2011
Opposition to enhanced human longevity, which often advocates collectivism and the use of government force to prevent other people from extending their lives through biotechnology, is based on a range of factors: fear of change, the green-eyed monster of envy (who has set up shop in the environmentalist movement these days), and ignorance of basic economics. In the latter case, some folk naively believe all resources to be limited - jobs, wealth, and so forth - rather than growing with population and length of life. But all of these things are made by people, and the more people there are and the longer those people live in good health, the more creation will take place. But there are always naysayers who have convinced themselves that a hundred thousand deaths due to aging every day and the ongoing suffering of hundreds of millions is necessary because of their own vague and unrealized anxieties about the future. Here is one example:

"Wolpe's own perspective is that our drive toward immortality is basically selfish. He sees few benefits to society, and a good deal of potential harm, in our living to 200 or beyond. There is a natural wisdom in replacing us. There's a natural wisdom in the idea that new people who arise in new circumstances have new perspectives on the world. Look at the generations living now from the World War II generation to the Baby Boomers, to Gen-X, all the way down.  The young generation today, the people in their teens and 20's today were steeped in a different brine than I was as a Baby Boomer. 

They were brought up with technology at their fingertips.  They move naturally and easily through that world.  And the idea that if I got to live to, you know, 150 or 200, that that would be a good thing for anyone other than me, I think is a misguided notion.  And there's a deep selfishness in the move towards immortality and these people like Aubrey de Grey and others who are really looking for that Fountain of Youth. If we don't change, for example, reproduction, if reproduction stayed between let's say, 20 and 40, that means that you would have another 80 years after reproducing that you'd be around. So there's even the question of how we're going to restructure the human lifespan. Is that a proper dynamic to have your children and then live another hundred years?" As usual, this is airy nonsense when held up against the reality of the vast and pervasive suffering caused by aging - suffering that we can work to address instead of just waffling about intangibles.

The use of nanoparticles to precisely deliver compounds to cells and specific locations within cells has a far broader application than just cancer therapies. Any existing drug that can be targeted this way can be made far more effective: provided in much smaller doses and with greatly reduced side-effects. For example: "Hitching a ride into the retina on nanoparticles called dendrimers offers a new way to treat age-related macular degeneration and retinitis pigmentosa. A study [shows] that steroids attached to the dendrimers target the damage-causing cells associated with neuroinflammation, leaving the rest of the eye unaffected and preserving vision.

There is no cure for these diseases. An effective treatment could offer hope to hundreds of millions of patients worldwide. [Researchers] tested the dendrimer delivery system in rats that develop neuroinflammation. The target was microglial cells, inflammatory cells in charge of cleaning up dead and dying material in the eye. When activated as 'trash collectors,' the cells cause damage via neuroinflammation - a hallmark of each disease. The microglial cells gobble up the dendrimers, and the drug then shuts down the cells' activity. Surprisingly, the activated microglia in the degenerating retina appeared to eat the dendrimer selectively, and retain them for at least a month. The drug is released from the dendrimer in a sustained fashion inside these cells, offering targeted neuroprotection to the retina. The treatment reduced neuroinflammation in the rat model and protected vision by preventing injury to photoreceptors in the retina. Though the steroid offers only temporary protection, the treatment as a whole provides sustained relief from neuroinflammation."

Via EurekAlert!: researcher have "developed a new method to design antibodies aimed at combating disease. The surprisingly simple process was used to make antibodies that neutralize the harmful protein particles that lead to Alzheimer's disease. Antibodies are large proteins produced by the immune system to combat infection and disease. Scientists have long sought methods for designing antibodies to combat specific ailments. However, the incredible complexity of designing antibodies that only attached to a target molecule of interest has prevented scientists from realizing this ambitious goal.

When trying to design an antibody, the arrangement and sequence of the antibody loops is of utmost importance. Only a very specific combination of antibody loops will bind to and neutralize each target. The new antibody design process was used to create antibodies that target a devastating molecule in the body: the Alzheimer's protein. We are actually exploiting the same protein interactions that cause the disease in the brain to mediate binding of antibodies to toxic Alzheimer's protein particles.

Alzheimer's disease is due to a specific protein - the Alzheimer's protein - sticking together to form protein particles. These particles then damage the normal, healthy functions of the brain. The formation of similar toxic protein particles is central to diseases such as Parkinson's and mad cow disease. Importantly, the new Alzheimer's antibodies [only] latched on to the harmful clumped proteins and not the harmless monomers or single peptides that are not associated with disease. [Researchers] see the potential for their technique being used to target and better understand similar types of protein particles in disorders such as Parkinson's disease.

A couple of videos on economics and engineered longevity, by G. Stolyarov II and Aubrey de Grey: "Mr. Stolyarov discusses how indefinite human life extension will bring about numerous economic benefits to human beings and human civilization. He approaches the subject from the standpoint of the idea of time preference and the time horizons that would be greatly expanded for humans who live much longer. Furthermore, indefinite human longevity will enable humans to confront major existential threats - such as the threat of a meteor impact or a new ice age - that are beyond the timeframe of the individual lifespan today. Radical life extension would have a huge impact on the economics of society - possibly a dangerous one.

Aubrey de Grey explains why he remains optimistic that the economy would adapt well to the drastically new paradigm presented by human immortality." Sadly, there's always someone out there who thinks that extended healthy human life is dangerous, despite the evidence of past centuries and many regions of the world that show greater life expectancy walks hand in hand with economic growth and higher standards of living. This is one of the reasons that advocacy for longevity science is even necessary in the first place. Nonetheless, the two upward trends of longevity and wealth are entwined and drive one another wherever they can start. But despite living in an age of change, so very many people fear change to the point of rejecting it even when it is overwhelmingly positive.

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