Longevity News Digest
Are You Overlooking this CRITICAL Longevity Step?
Dear Future Centenarian,Â
It™s so simple. It™s so cheap. It can even be free.
But it™s deficiency is making millions sick¦ and dead. In fact, some governments actually warn against it.
I™m talking about one of the more studied and validated¦ yet one of the more overlooked vitamins on the planet “ Vitamin D3.
Here are excerpts from a June, 2014 Bioscience and Technology article that demonstrate how absolutely insane it is to skip this KEY wellness step:
œResearchers at the UCSD School of Medicine have found that persons with lower blood levels of Vitamin D were twice as likely to die prematurely as people with higher blood levels.
"This new finding is based on the association of low Vitamin D with risk of premature death from all causes, not just bone diseases.
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œThe blood level amount of Vitamin D associated with about half of the death rate was 30 ng/ml. Two-thirds of the U.S. population has an estimated blood Vitamin D level below 30 ng/ml.
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"This study should give substantial reassurance that Vitamin D is safe when used in appropriate doses up to 4,000 international units (iu) per day. Daily intakes above 4,000 iu per day may be appropriate for some patients under medical supervision.
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œThe average age when the blood was drawn in this study was 55 years. The study included residents of 14 countries, including the United States, and data from 566,583 participants.
You can find the article HERE.
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As you probably know by now, your best source of D3 is¦ THE SUN!
After the Aussies were publicly warned to cover up and to use sunscreen to avoid skin cancer, many took heed. And the incidence of skin cancer did indeed go down. But what the government did not take into consideration was that D3 is one of the stronger protectants against cancer in general.
So what happened? A measurable uptick of deadly cancers.
Sure, excessive sun damages your skin, especially the sensitive skin on your face. So splatter sunscreen on your face or wear a hat. But expose the rest of your skin (that is legally permissible in your local jurisdiction) to the sun for 20-40 minutes a day (depending on how fair you are) at least a couple of days a week.
So what do you do if you work indoors? Or during winter months? Easy. Pop a pill a day. Cost? 5000 IU of D3 is maybe a dime a day. Cheaper than the sun tan lotion that blocks its benefits in the first place.
If you haven™t read my section on D3 in Smart, Strong and Sexy at 100 yet, I suggest you review it or get the book now. I poured my soul into that book, because it could be all that stands between you and extreme healthy longevity. Maybe between life and death. Here™s your link.
Finally, I have a bonus for you. Dr. Pompa™s Anti-Aging Secret #1 (maybe not a secret to you, but a good reminder¦ just like Vitamin D) https://www.youtube.com/watch?v=101Jbr4g4z4
Latest Headlines from Fight Aging!
A Novel Form of Cancer Immunotherapy - Monday, June 23, 2014
The immune system is very complex and one of the least understood areas of our biology, which is reflected in the presently poor knowledge of the causes of autoimmune disorders and lack of effective treatment options.
There is a lot of work taking place on manipulating the immune system to attack cancer, however, and this and other work on immunity will in the years ahead establish the understanding that is presently lacking. This research is an example of the type, and may ultimately turn out to be more valuable for what it reveals about the immune system rather than its use in cancer treatment.
Working on the Next Generation of Prototype Artificial Vision - Monday, June 23, 2014
Artificial vision devices are presently very crude: grids of electrodes embedded in the retina that can stimulate retinal cells to create the appearance of a pattern of glowing dots based on what a camera sees.
This is enough to pick out letters, navigate a room, or distinguish faces with practice, which is a big step up from being absolutely blind. These are still prototypes, however, steps on the way to better things. Researchers are laying the groundwork for more a subtle integration between microelectronic devices and retinal cells.
The SENS Approach to Mitochondrial Damage in Aging - Tuesday, June 24, 2014
It is always good to more respectful attention given to the Strategies for Engineered Negligible Senescence (SENS) approach to rejuvenation treatments. Rendering us immune to mitochondrial DNA damage and its consequences is just one of a number of future therapies that will be needed to reverse all of the underlying causes of aging, but in and of itself this is perhaps the most technically interesting of the biotechnologies adopted and advocated by SENS.
Speculative Calorie Restriction Research in Nematodes - Tuesday, June 24, 2014
Calorie restriction extends life and slows progression of near all measurable aspects of aging in near all species tested to date.
The underlying mechanisms are inherited from the deep evolutionary past and are therefore very similar even between yeast, nematode worms, mice, and humans. One of the most interesting things about the calorie restriction response is that researchers can study nematodes and then have a fair expectation that much of what is learned will have some relevance to human biochemistry.
There are of course limits to the degree to which one can take findings in lower animals and expect them to hold up in humans. Nematodes for example have a dauer stage in growth that they enter and exit based on environmental circumstances: it is a form of stasis in which they can survive for great lengths of time in comparison to their normal life span. Effects that involve the dauer stage are unlikely to be of any great relevance to higher species that do not have this capability, however. So I think it is very speculative that this research will have any great application to human metabolism, for all that it is well crafted.
A Review of Immunotherapy for Alzheimer's Disease - Wednesday, June 25, 2014
Why build a completely new method of removing unwanted proteins or destroying unwanted cells, when a system capable of these tasks already exists in the body?
That is the idea behind the many different forms of immune therapy, technology platforms that will come to be commonplace in medicine over the next few decades. Here is an open access review of the recent past and near future approaches to enlisting a patient's immune system to treat Alzheimer's disease.
Drug Discovery in Search of Ways to Boost Autophagy - Wednesday, June 25, 2014
There is a wealth of evidence to show that benefits to health and longevity result from increased levels of autophagy in various species.
Autophagy refers to processes of cellular housekeeping that remove damaged components, and which have been found to operate with greater enthusiasm as a result of a range of different interventions in laboratory animals that increase life span and slow the progression of aging. Indeed, some researchers believe that increased autophagy is an important contribution to all of these longevity-enhancing approaches.
Given this it is surprising to see so little effort going towards drug discovery with safely increased autophagy as the primary target. As is usually the case, where drug discovery is undertaken, efforts are first focused on repurposing existing drugs that are already approved, even if the effects are marginal.
This is because it costs much less to try to obtain regulatory approval for a new use of an existing drug than to push through a completely new medical technology - one of the many ways in which medical regulation distorts the research process in the direction of deliberately aiming for inferior results and slower progress towards new knowledge.
A Lower Mortality Rate for Vegetarians - Thursday, June 26, 2014
Studies show that vegetarians tend to have modestly lower mortality rates, but as for all such observations of human populations there is plenty of room to debate why this is the case.
All the normal arguments can be deployed: that a vegetarian diet tends to result in a lower calorie intake and thus less excess fat tissue, that it is more often practiced by people who are more health-conscious in the first place, that it is associated with greater wealth and education, that it results in a lower intake of dietary advanced glycation end products, and so forth. But which of those factors are more important? Therein lies the question.
The development of better medical technologies in the future has the goal of making all of this sort of debate over health practices irrelevant. Rejuvenation biotechnology and other forms of new medicine should render it moot as to how you lived your life: the benefits provided to health and longevity will be enormous in comparison to those derived by living well.
But we are not there yet, and there are decades yet to get past if we want to benefit from the rejuvenation treatments presently in very early development. These research press materials are an odd mix of environmentalist and health concerns, and I point it out for the latter, not the former.
Improving the Infrastructure for Therapeutic Transfer of T Cells - Thursday, June 26, 2014
I suspect that we'll see spreading use of immune cell transfer therapies in the years ahead. The time is right for it: stem cell researchers are continually improving their ability to generate cells to order, knowledge of how the immune system works in detail is growing, and so is the understanding of just how important immune system decline is in aging.
Somewhere between today and a future in which an age-damaged immune system can be completely restored to youthful function lies a span of decades in which regular infusions of tailored immune cells are a routine part of older life, a treatment that temporarily enhances immune system function across the board, or which can be used to attack specific targets such as an infection or a cancer.
For this to come to pass the infrastructure for such therapies must improve, becoming more efficient, more reliable, and much less costly than is presently the case. This is happening now, step by step, such the progress cited in this article. It is aimed at use for transplant patients, but should be relevant to a range of similar future applications.
Longevity Correlates with Childbirth at Later Ages - Friday, June 27, 2014
There is a natural range of variation in the pace of aging that is largely determined by lifestyle until later old age, at which point genetic influences become more important.
Aging is a global phenomenon throughout the body: if someone ages more rapidly, it tends to be the case that every manifestation of aging is worse at any given chronological age. So when researchers find ways to measure an aspect of aging at one age, it should be expected that this measure correlates statistically with differences in future life span.
Fasting May Be a Useful Addition to Many Medical Procedures - Friday, June 27, 2014
Intermittent fasting can extend life in laboratory animals and was recently demonstrated to improve immune function under at least some circumstances.
There is a fair amount of research that demonstrates the benefits of fasting in conjunction with standard cancer treatments. The changes in metabolism that take place during fasting may make it a useful addition to a range of medical procedures, improving outcomes and survival rates. Here is one example of supporting evidence for this assertion.
DISCLAIMER:Â News summaries are reported by third parties, and there is no guarantee of accuracy. This newsletter is not meant to substitute for your personal due diligence and is not to be taken as medical advice. For originating report, please see www.fightaging.org/
David A. Kekich
Maximum Life Foundation
"Where Biotech, Infotech and Nanotech
Â Â Â Â Meet to Reverse Aging by 2033"