Extreme Life Extension Research
New Book Opens Your Door to Endless Youth Technology
posted on September 22, 2009
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I had an interesting week. In conjunction with Life Extension Foundation (LEF) and Greta Blackburn, we played host to many of the Emmy award actors, actresses and other entertainment industry personalities. It was a pre-Emmy Award event where celebrities go to try out your œstuff and to hype the Emmys.
It was a fun event from which I learned a few things. First, the celebrity crowd is much younger than I thought. They somehow look older on TV. It™s been years since I watched much television, and now I know another reason why. I thought was simply a waste of time for most shows, and for me, it is. That™s because most of the shows target audiences from teenagers to the thirty-somethings. So the experience made me feel old. Ouch! But it also strengthened my resolve to recapture my youth.
The second thing I learned is the young hip Hollywood crowd is not in tune with life extension. In fact, many did not even know what œlife extension means. But once they get to be around thirty that changes. Those over forty were almost unanimously fascinated by what is and what might be available to them.
We went to the show to make the entertainment industry more aware of healthy life extension possibilities. Of course, they were almost all interested in beauty enhancements. But they seemed to be more aware of surgical answers then the non-invasive approaches LEF offers. And for the most part, they knew little to nothing about extreme life extension possibilities and technologies.
This will soon change. The entertainment industry has more influence than most, and they gravitate toward anything that could make them younger or appear younger. That™s why we were there. By educating only that core group, we can leverage our way to much wider audiences. That in turn legitimizes an industry that many perceive as one that is top heavy with quacks selling their snake oils to a desperate crowd. Once they understand what works and what doesn™t, and once they understand that science-based age reversal may no longer be an impossible dream for them, it will no longer be an uphill battle getting them to support the research.
Life Extension Express clearly explains the concept and was written to change the way most people think about the inevitability of aging and decline. Get your copy now at
LATEST HEALTHY LIFE EXTENSION HEADLINES
THE OXIDATION-INFLAMMATION THEORY OF AGING (September 18 2009) http://www.maxlifesolution.com/inflammex/
An interesting paper: "The aging process is one of the best examples of the effects of a deterioration of homeostasis, since aging is accompanied by an impairment of the physiological systems including the homeostatic systems such as the immune system. We propose an integrative theory of aging providing answers to the how (oxidation), where first (mitochondria of differentiated cells) and why (pleiotropic genes) this process occurs. In agreement with this oxidation-mitochondrial theory of aging, we have observed that the age-related changes of immune functions have as their basis an oxidative and inflammatory stress situation. Moreover, we have also observed that several functions of immune cells are good markers of biological age and predictors of longevity. Based on the above we have proposed the theory of oxidation-inflammation as the main cause of aging. Accordingly, the chronic oxidative stress that appears with age affects all cells and especially those of the regulatory systems, such as the nervous, endocrine and immune systems and the communication between them. This fact prevents an adequate homeostasis and, therefore, the preservation of health. We have also proposed a key involvement of the immune system in the aging process of the organism, concretely in the rate of aging, since there is a relation between the redox state and functional capacity of the immune cells and the longevity of individuals."
AN INTERVIEW WITH MEREDITH AVERILL AND PAUL MCGLOTHIN (September 17 2009) http://www.longevitymeme.org/news/vnl.cfm?id=4383
h+ Magazine interviews calorie restriction (CR) practitioners Meredith Averill and Paul McGlothin, noted for their work to spur the scientific community into greater human studies of CR: "McGlothin says he 'had the good fortune' to come into contact with one of the country's leading internist, who is a calorie restrictor. It was through this physician that McGlothin and Averill both became smitten with CR practice and science and surrounded themselves with a team of doctors in an attempt to sort out fact from fiction in the practice. They also initiated the first CR study of humans, accomplished with MetaMetrix Clinical Laboratory in 2001.
Subsequently, they formed a partnership with Drs. Luigi Fontana and John Holloszy at the Washington University in Saint Louis School of Medicine. His work in testing CR results led to his being named Research VP of the CR Society, where he works with scientists to plan studies. We want everything we do to be backed by solid scientific research and testing. That is why we helped set up the first longitudinal study of calorie-restricted humans. Now, for the past seven years, we and a cohort of other calorie-restricted humans have been thoroughly tested by teams of scientists headed by Drs. Luigi Fontana and John Holloszy at the School of Medicine at Washington University in St. Louis."
A PROFILE OF LEONARD GUARENTE (September 16 2009) http://www.longevitymeme.org/news/vnl.cfm?id=4381
Aging researcher (and competitor in the Mprize for longevity science) Leonard Guarente is profiled at the MIT News: "After winning tenure at MIT in 1986, biology professor Leonard Guarente did some soul-searching. He had made his mark by studying gene regulation in yeast, but that field was getting overrun with researchers, and he wanted to pursue a riskier project, where success would have a dramatic scientific impact. With the help of some bright graduate students who arrived in his lab in 1991, he hit on the idea of looking for genes that control aging in yeast. At the time, it was a plan with little prospect for success: Few scientists believed that aging might be controlled by a single gene (or small group of genes). Guarente turned that view around - and pioneered a new field of study - with his discovery of so-called longevity genes, which dramatically boost the lifespan of yeast, worms, mice and potentially humans. The human version of the gene, known as SIRT1, is now the target of several drugs in development to treat the diseases of aging, including diabetes, Alzheimer's and cardiovascular disease."
ON THE REVIVAL OF CRYONICS PATIENTS (September 16 2009) http://www.longevitymeme.org/news/vnl.cfm?id=4380
Over at Depressed Metabolism, Aschwin de Wolf has assembled a list of literature on how we expect cryosuspended people to be restored in the future. The general class of technologies required are fairly well understood, and a lot of thought has gone into the processes and machineries that must be developed: "There is a growing literature that discusses the technical aspects of revival of cryonics patients. [This list] of the published literature was compiled by Ralph Merkle and Robert Freitas and published as an appendix of their article on molecular nanotechnology in Cryonics Magazine 2008-4." Much of the list is available online for interested readers, such as Merkle's technical feasibility outline: "This paper considers the limits of what medical technology should eventually be able to achieve (based on the currently understood laws of chemistry and physics) and the kinds of damage caused by current methods of freezing. It then considers whether methods of repairing the kinds of damage caused by current suspension techniques are likely to be achieved in the future."
DECIPHERING THE GERMLINE-LONGEVITY LINK (September 15 2009) http://www.longevitymeme.org/news/vnl.cfm?id=4379
Researchers are making progress in understanding exactly how germline cells are linked to longevity in flies and nematodes: "In Caenorhabditis elegans and Drosophila melanogaster, the aging of the soma is influenced by the germline. When germline-stem cells are removed, aging slows and lifespan is increased. The mechanism by which somatic tissues respond to loss of the germline is not well-understood. Surprisingly, we have found that a predicted transcription elongation factor, TCER-1, plays a key role in this process. TCER-1 is required for loss of the germ cells to increase C. elegans' lifespan, and it acts as a regulatory switch in the pathway. When the germ cells are removed, the levels of TCER-1 rise in somatic tissues. This increase is sufficient to trigger key downstream events, as overexpression of tcer-1 extends the lifespan of normal animals that have an intact reproductive system. Our findings suggest that TCER-1 extends lifespan by promoting the expression of a set of genes regulated by the conserved, life-extending transcription factor DAF-16/FOXO."
DISABLING MITOCHONDRIAL GENES FOR LONGEVITY (September 15 2009) http://www.longevitymeme.org/news/vnl.cfm?id=4378
Researchers make flies live longer by interfering with components of the mitochondrial energy-generating machinery: "Mitochondria have long been proposed to play an important role in the aging process. In the nematode Caenorhabditis elegans, genes important for mitochondrial electron transport chain (ETC) function stand out as a principal group of genes affecting life span. However, it has been suggested that this may be a peculiarity of nematode biology. In the present study, we have used an in vivo RNA interference (RNAi) strategy to inactivate ETC genes in Drosophila melanogaster and examine the impact on longevity. RNAi of five genes encoding components of mitochondrial respiratory complexes I, III, IV, and V leads to increased life span in flies. Our data suggest that the role of mitochondrial ETC function in modulating animal aging is evolutionarily conserved and might also operate in humans. Furthermore, our findings suggest that the longer life span of flies with reduced ETC gene expression cannot simply be attributed to reduced energy production leading to decreased 'rate of living.'"
SEEKING THE CURE FOR AGING (September 14 2009) http://www.longevitymeme.org/news/vnl.cfm?id=4377
The Telegraph notes the recent SENS4 conference: "Cranks and crooks have been peddling immortality potions since before the dawn of history. All manner of bizarre antidotes to ageing have been tried, including the drinking of mercury salts and the eating of diced monkey testicles. Immortality, it would seem, has long been inextricably entwined with lunacy. But that may be about to change. Earlier this month, 200 scientists descended on Queens' College Cambridge to discuss ways of radically extending human lifespan - and even achieving immortality. The Strategies for Engineered Negligible Senescence (SENS) conference, drew together researchers from disciplines as diverse as tissue engineering, artificial intelligence, law, demographics and politics. 'Most people fail to understand how fast medical science is advancing in this area,' says the conference organizer Dr Aubrey de Grey, editor-in-chief of the journal Rejuvenation Research and co-founder of the SENS Foundation. 'Conventional medical progress has ensured that a child born today can expect to live 120 to 150 years. I think it's possible for them to live far longer. If we make the right breakthroughs in the next 25 years, then there is a 50:50 chance that people alive today could live to be 1,000 years old."