Healthy Life Extension
Who is that Dragon Lurking Behind You?
Dear Future Centenarian,
I hope you like short stories. I know you have an interest in longevity.
Nick Bostrom, a Swedish philosopher at the University of Oxford, expresses his passion for longevity to a fascinating level with his short story, The Fable of the Dragon-Tyrant.
This is one of the more clever, right on-the-mark, entertaining and uplifting stories I have read. I first saw it at least five years ago, and now it™s ANIMATED.
Nick is a fascinating guy. Although our paths have not yet crossed, I have read about him and have read things by him for years. He™s a popular speaker as well as a prolific writer on topics ranging from existential risks to super-intelligence. His work has been translated into more than 20 languages, and there have been some 100 translations or reprints of his works.
I look forward to meeting him one of these days.
Reason likes him too and says œFable of the Dragon-Tyrant is a noted modern morality tale, written to highlight our acceptance of death by aging, and more importantly our grand, widespread failure to work towards building therapies to treat aging.
œEven though the research community now knows enough to achieve that goal, and even though biotechnology is in the midst of an unprecedented revolution in capacity and capabilities, research aimed at producing human rejuvenation is hardly funded at all in comparison to other more prosaic fields.
œFurther, if asked, most people gladly declare that they have no interest in living longer or treating aging as a disease to be cured - despite the fact that they would no doubt be among the masses taking advantage of rejuvenation therapies were those treatments available, just as they now take advantage of modern medicine unavailable to their ancestors.
œSo we march towards death and suffering, doing next to nothing about this avoidable fate. It is this sort of everyday madness that inspires the writing of fables.
œYou might recall that a couple of years back there was some talk of animating the Fable of the Dragon-Tyrant. This was generally agreed to be a good idea. I'm pleased to note that someone actually went ahead and did it. Follow [this] link [below] to watch the animation.
Nick™s homepage is www.nickbostrom.com
LATEST HEADLINES FROM FIGHT AGING!
ANOTHER STEP TOWARDS EARLY ARTIFICIAL CELLS Friday, April 5, 2013
It is worth keeping an eye on progress towards the creation of artificial cells and cell-like structures, as they are potentially useful in a very broad range of biotechnologies relevant to longevity science, regenerative medicine, and so forth.
The first swarms of medical microrobots will quite likely be modified cells or artificial cells, packed with specific forms of molecular machinery to achieve some sort of effect in the body - such as manufacturing signaling compounds in response to local conditions, so as to steer the activities of surrounding cells.
LONGER LIFE OR UNLIMITED LIFE? Friday, April 5, 2013
This article looks past the immediate challenges of aging and early medical biotechnologies aimed at extending human longevity, and into the future of merged molecular manufacturing and biotechnology, when it will become possible to replace our biology with far more robust and long-lasting machinery:
"If we're talking far-future, non-biological approaches to life-extension will win out over biological approaches, due mainly to their comparative advantages (e.g. ease of repair and modification).
WITHIN A SPECIES, LARGER SIZE TENDS TO MEAN A SHORTER LIFE Thursday, April 4, 2013
You might look at this research on size and longevity in the context of what is known of growth hormone and aging.
The presently longest lived mice, for example, are those in which growth hormone is removed or blocked, and they are small in comparison to their peers.
AN EXAMPLE OF MITOHORMESIS Thursday, April 4, 2013
Mitohormesis is a process by which a low dose of some toxic substance or environmental effect causes mitochondria in cells to emit a little more in the way of damaging reactive oxygen species, which in turn causes cellular maintenance mechanisms to ramp up their efforts.
The end result is a net gain in health and longevity:
ON HUNGER WITHOUT CALORIE RESTRICTION Wednesday, April 3, 2013
It is suspected that some fraction of the benefits of calorie restriction for health and longevity are keyed to the hunger response in some way - i.e. that being hungry more often is necessary to gain the full effects.
There's not all that much work on this so far as I'm aware, however.
A TRIAL OF VERY SMALL EMBRYONIC-LIKE STEM CELLS FOR BONE REGROWTH Wednesday, April 3, 2013
"Very small embryonic-like stem cells" (VSELs) is one name given to populations of stem cells in the adult body that appear to share some characteristics with embryonic stem cells - such as the ability to differentiate into multiple cell types.
If this pans out, these cells will be useful in therapy - and here is news of an upcoming trial:
PHARMACOLOGY LAGS BEHIND GENETIC ENGINEERING AND ENVIRONMENTAL CAUSES OF LONGEVITY Tuesday, April 2, 2013
This is a somewhat obvious point, but seems worth making once or twice.
The primary methods of extending life in laboratory animals involve genetic engineering and environmental line items such as calorie restriction - these are how new metabolic states that lead to increased longevity are discovered in the research mainstream.
Read More http://www.fightaging.org/archives/2013/04/pharmacology-lags-behind-genetic-engineering-and-environmental-causes-of-longevity.php
OLD BLOOD VERSUS YOUNG BLOOD FROM A PROGRAMMED AGING PERSPECTIVE Tuesday, April 2, 2013
The programmed aging camp points to experiments such as this as supportive of their view that aging is a genetic program that gives rise to damage and change, rather than resulting from damage that causes epigenetic changes to arise in reaction.
The data could be interpreted either way, however, and there are other reasons to believe that aging is caused by damage:
THE IMPORTANCE OF AUTOPHAGY FOR MITOCHONDRIA Monday, April 1, 2013
Mitochondria are the powerplants of the cell, bacteria-like entities that produce chemical stores of energy to power cellular processes.
The accumulation of damaged mitochondria is thought to cause a fair portion of degenerative aging, and differences in the ability of mitochondria to resist damage appear to play an important role in determining variation in life span between similar species.
HEIGHT LOSS CORRELATES WELL WITH OTHER ASPECTS OF AGING Monday, April 1, 2013
Aging is a global phenomenon throughout the body, and thus we should expect the pace of progression of any one aspect to correlate well with the others.
So it is for height loss - meaning that you have the same modest level of control via lifestyle choices such as exercise and calorie restriction as is the case for aging in general:
DISCLAIMER:Â News summaries are reported by third parties, and there is no guarantee of accuracy. This newsletter is not meant to substitute for your personal due diligence and is not to be taken as medical advice. For originating report, please see www.fightaging.org/
David A. Kekich
Maximum Life Foundation
"Where Biotech, Infotech and Nanotech
Â Â Â Â Meet to Reverse Aging by 2033"