Longevity News Digest
The #1 Longevity Lesson that I Learned
Dear Future Centenarian,Â
Recently, a new friend pointed out to me that one of the biggest lessons I learned through my experience was that overcoming life™s challenges has a lot to do with attitude.
I™ve been thinking about that and realized that one little step I took over thirty years ago may prove to put you on the path to extreme longevity.
An old friend used to talk about right turns and left turns. What he meant was, whatever decision you make could, and usually does affect the rest of your life and the lives of those around you. Sometimes small effects. Sometimes big. But they all change your point of reference. Sometimes not consciously noticeable¦ and sometimes majorly.
An opposite decision could have entirely different effects on you and others.
And this is a never ending process.
Let me tell you about one small turn in my life that brought me to where I am today, how I ended up starting this newsletter seven years ago, and how I got immersed in the pursuit of radical life extension.
You may know that I had a devastating injury a long time back that made me think my life came to an end. After a few years, I gradually regained my healthy attitude. And here™s what my early attitudinal changes grew to:
After turning into a semi-slug after I got hurt, I eventually started a local chapter of the Spinal Cord Society. Then I held a successful fundraiser for paralysis research¦ and realized my brain still worked.
That gradually got me out of my funk and put me back on the path to actually having a life.
Over time, I turned my efforts toward longevity and held an oldies dance fundraiser for Maximum Life Foundation. Proceeds funded our first international longevity research conference. That conference spawned a bona fide scientific roadmap to not just slow, but to actually reverse aging.
How cool is that?
One researcher, who was unknown at the time, formulated his strategy to repair the damage that aging causes during the conference.
Now he™s internationally famous, and his foundation has raised millions of dollars, funding a network of research projects at about ten major universities.
The ripple effect from that conference ended up having a direct and potentially big influence on a Google funded and sponsored company dedicated to curing aging.
Maybe most importantly, all this led to our funding a special advanced form of artificial intelligence that has discovered the genetic network codes for what causes inflammation, aging brain weaknesses, possibly weight loss¦ and aging itself.
But that™s not all.
The AI then discovered networks of natural compounds to address these issues that all too often, make life suck. After extensive testing, we recently introduced the first of these targeted and effective nutritional supplements.
I want to point out that these discoveries go far beyond what humans are capable of doing on their own.
What™s the encore performance going to be?
An AI scientist that could be hundreds of times as effective as teams of humans. Incredible, huh? Soon, we™ll start looking to a few investors for a surprisingly small amount of money to develop a working model within two years.
AI will be the tool that changes the landscape of humanity, and it™s a thrill being a part of this. AND THIS ALL STEMMED FROM ONE SMALL ACTION STEP AND ONE SMALL CHANGE IN ATTITUDE.
So. Simply put, attitude is everything.
Let me repeat that. œAttitude is everything. What happens to you is not nearly as important as how you react to it.
Attitude is the backbone of professional and personal success too¦ and life itself.
It™s so important that I devoted a chapter to it in my book, Smart, Strong and Sexy at 100?
In fact, in many ways, it™s the most important chapter. For one thing, the left and right turns that led to my even writing the book would not have happened if it weren™t for the single little step that led to my change of attitude.
But it™s mainly the most important chapter because it lays the foundation for your healthy longevity.
We ALL have issues holding us back from time to time. No one is exempt. Those that are able to consistently overcome are the ones who achieve everything from massive business success to managing the personal stuff that stands in the way of everything we want to do.
What stuff stands in your way?
We should all know by now what it takes to optimize our wellness. But few of us do it. If you know any of these people, have them read or reread Chapter 7.
Latest Headlines from Fight Aging!
Are All Those Memory T Cells Present in the Elderly in Fact Due to CMV Exposure? - Monday, February 17, 2014
The failing immune system of the elderly is characterized by a greatly increased number of memory T cells, and too few naive T cells capable of taking on new threats.
One explanation for why this is the case is exposure to cytomegalovirus (CMV), a ubiquitous herpesvirus that the immune system cannot clear. Ever more T cells become uselessly devoted to fighting it until the immune system can no longer do its job. There are research results from human studies to support this view. It isn't the only reason that the immune system fails, but it may be one of the more important ones.
These researchers see a different picture when working in mice, however. To their eyes memory T cells are expanding in number with age due to some other process, something yet to be fully understood. CMV may prove to be a red herring yet, or this may turn out to be a significant difference between the immunology of mice and people.
Decellularization Demonstrated in Human Lungs - Monday, February 17, 2014
The lung is a very complex organ, and that complexity is one reason why the tissue engineering of lungs is lagging behind that of other, less complex organs. It will be a while yet before any organ can be reliably grown from the starting point of a patient's own cells - though groups like the New Organ initiative hope to speed the arrival of that goal.
There is a technology to bridge the gap between the donor transplants of today and the organs grown to order of tomorrow, however: it is decellularization. A donor organ can be stripped of its cells, leaving only the structure of the extracellular matrix. When new cells are introduced, such as those derived from a recipient's stem cells, they are guided by the scaffold and chemical cues of the extracellular matrix to reassemble the correct tissues.
The end result is an organ that will match the patient with little to no threat of immune of rejection. It will even possible to use organs from pigs or other similarly sized animals to create a source of decellularized tissues for transplantation.
A few years ago researchers demonstrated the ability to create and transplant decellularized rat lungs. Here this popular science article notes that decellularization in human lungs has reached the proof of concept stage. It is interesting to see that researchers are far more ready to put timelines for development on the table than they were in past years.
Multiplying Still-Functional Old Muscle Stem Cells to Reverse Age-Related Muscle Declines - Tuesday, February 18, 2014
Researchers here demonstrate a way to restore old muscle stem cell populations to youthful levels of activity and tissue maintenance, and show that it produces benefits in old mice.
More Mitochondrial DNA in Long-Lived Individuals - Tuesday, February 18, 2014
A herd of mitochondria exist in every cell, each with their own copies of mitochondrial DNA.
Mitochondria replicate like bacteria, and mitochondrial dynamics are complex and reactive. So counting mitochondria, such as by measuring levels of mitochondrial DNA, doesn't necessarily tell us anything about cause and effect.
If we see this measure declining with aging, but not in long-lived individuals, that really only says that we might want to look more closely at the role of mitochondria in aging. Long-lived individuals are long-lived precisely because they have less damage and fewer age-related changes in their biochemistry.
Suggesting That Mitochondrial Changes Are Consequences, Not Causes of Aging - Wednesday, February 19, 2014
It is thought that mitochondrial DNA damage - and consequent mitochondrial dysfunction - is a contributing cause of aging.
There is plenty of evidence to support that view, but it still lacks the sort of conclusive proof needed to sink all arguments, such as engineering longer life for laboratory animals through mitochondrial DNA repair, something that will soon be possible. Here, researchers look at specific forms of age-related mitochondrial change in nematodes and suggest that they are consequences, not causes of aging.
More Evidence Against a Late-Life Mortality Plateau in Mammals - Wednesday, February 19, 2014
At the high level aging is defined as an increase in mortality rate with time due to intrinsic causes. By this definition some species become "immortal" in old age: their mortality rates grow to become high but then cease to rise further in the final stage of life.
The best data for this effect has been gathered in flies, and a lot of theorizing has taken place on what this might mean for the evolution of aging. Finding this same effect in humans is a more challenging undertaking, as the data for human aging in extreme old age is sparse.
he number crunching to date has leaned strongly towards there being no slowing of the increase in mortality rate over time in humans, and certainly no late life mortality plateau of the sort that occurs in flies. Here is a recent publication on this topic.
A Programmed Aging Theory Involving RNA - Thursday, February 20, 2014
These researchers put forward a theory of programmed aging that is based on the interactions between RNA populations and the genome.
At present the mainstream view is that aging is not programmed, but rather a matter of stochastic accumulation of damage and the reactions to that damage - therefore developing methods of repair is the best way to prevent and reverse aging. No view in a developing field is ever shared universally of course.
Immunotherapy Effective Against Advanced Leukemia - Thursday, February 20, 2014
The next generation of cancer treatments will be targeted approaches that destroy only cancer cells, with few or no side-effects.
Given the results of the past decade of work, it looks likely that a majority of these treatments will be immune therapies, in which a patient's immune cells are engineered or trained to identify and attack the cancer. Clinical trials for a few such therapies are ongoing, mixed in with established treatment options. This is an example one of the more effective applications to date.
Protein Misfolding and Reversal of Age-Related Sleep Issues - Friday, February 21, 2014
An interesting relationship between cellular maintenance machinery and age-related issues with sleep is uncovered and partially reversed by researchers here - though I would like to see more work on this topic before going along with their interpretation as to what is happening under the hood.
Accelerometer Studies Show That Even Marginal Differences in Activity Have Noticeable Effects on Health - Friday, February 21, 2014
Wearable accelerometers are a comparatively new development in studies of the effects of exercise and activity on health. One of the outcomes is better evidence to suggest that even activities that don't rise to the level of what most people would consider exercise do in fact make a difference - standing versus sitting, for example.
DISCLAIMER:Â News summaries are reported by third parties, and there is no guarantee of accuracy. This newsletter is not meant to substitute for your personal due diligence and is not to be taken as medical advice. For originating report, please see www.fightaging.org/
David A. Kekich
Maximum Life Foundation
"Where Biotech, Infotech and Nanotech
Â Â Â Â Meet to Reverse Aging by 2033"