Pain – Aging sucks

Healthy Life Extension

Funding Aging Research

Pain


posted on June 12th, 2012

Dear Future Centenarian,

In the off chance I haven™t made myself clear the past six years, let me put it this way:

œAging sucks!

Almost, but not everything about aging is negative. Sure, we should gain more wisdom, accumulate fond memories, see our children and grandchildren evolve and hopefully become financially secure.

Before I get into the negative aspects of aging, let™s look deeper into the positive ones I have mentioned.

  1. Wisdom “ Close to half of us get Alzheimer™s by age 85. More after that. So wisdom gets erased. If you dodge dementia, aging kills you, and there goes the wisdom for those who do not get demented.
  2. Fond memories “ See #1.
  3. Progeny “ We™re limited as to how many generations we can enjoy. Then you break their hearts when you die.
  4. Financial security “ Most people kiss their nest eggs goodbye to pay for late-age medical care. If you™re real lucky, you die rich and leave your hard-earned fortune to others to enjoy.

 

Before I go any further, let me point out I™m not being cynical, just realistic. It may not be politically correct to burst the rosy picture that aging proponents and apologists paint and glorify, but we™re not going to solve a problem as major as curing aging by being delicate.

Now to get into the meat.

Here is a partial list of the aging-related horrors we are determined to put an end to:

  1. Chronic pain “ Intense pain, acute or chronic, may be the single most difficult thing to cope with, young or old. When it gets severe, it overrides nearly every thought you may want to hold on to. You know what I mean, don™t you? Unfortunately, chronic pain goes hand-in-hand with aging more often than not.
  2. Heart disease “ The single biggest killer. Solving aging goes a long way to eliminating this one.
  3. Cancer “ This horrifying disease is the second biggest killer and is largely a disease of aging.
  4. Arthritis “ Cure aging and mostly eliminate the fear of being crippled by this painful disease.
  5. Osteoporosis “ This is not a friendly prospect. It™s crippling and causes deadly falls.
  6. Dementia “ Lose your sense of identity and death can be a welcome reprieve.
  7. Hearing loss “ This goes way beyond an annoyance and keeps getting worse with age.
  8. Visual impairment “ I don™t know of a single aged friend who does not need reading glasses with the exception of some nearsighted people. Then consider cataracts, glaucoma, macular degeneration and more.
  9. Loss of independence “ Animals in the wild die from this. People decay in nursing homes.
  10. Loss of strength, energy and endurance “ Are you feeling this yet? It gets worse.
  11. Faded looks “ Who doesn™t want to look their best? We just don™t when we™re old.
  12. More¦ including of course, the inevitability of death

 

No wonder people don™t dwell on this issue. Except for some philosophers, throughout history, we usually learned to suppress these thoughts. And wegenerally found some rationalizations or even good in aging and death. Why not? We couldn™t stem the tide. It was our destiny to deteriorate and die, so we made the best of it.

But I™m here to tell you, it™s a new era. We finally know how aging may be cured and are building the tools to make it a reality. With enough support, it can happen in your lifetime.

More Life,
David Kekich

P.S.  Two weeks ago, I offered you a free Kindle version of Smart, Strong and Sexy at 100? Were you one of the many hundreds who downloaded it? If so, did you get a chance to read it yet? If you did, you now understand how and why we can expect to be rejuvenated one of these days. You also now know how you can improve your odds.

P.P.S. If you found my book worthy of a 5 star review, won™t you take a moment to give it one on the Amazon site? Please go to http://www.amazon.com/Smart-Strong-Sexy-100-ebook/product-reviews/B00865MDJC/ref=sr_cr_hist_all?ie=UTF8&showViewpoints=1 and click on œCreate your own review.
______________________________

LATEST HEADLINES FROM FIGHT AGING!

POPULAR PRESS ON INTERMITTENT FASTING Friday, June  8, 2012
Andrew Weil, who is something of an apologist for aging, here holds forth on the merits of intermittent fasting (IF) - shown to improve health and extend life in laboratory animals through mechanisms that largely, but not entirely, overlap with those of calorie restriction:

"An IF regime works, proponents say, because it aligns with our evolutionary history. Over the 250,000 years that Homo sapiens have been around, food supply has waxed and waned. We evolved to take advantage of this fact, building muscle and fatty tissue during times of abundance, then paring it back during lean ones. Fasting periods accelerate the clearing-out of waste left by dead and damaged cells, a process known as autophagy. A failure of autophagy to keep up with accumulated cellular debris is believed by many scientists to be one of the major causes of the chronic diseases associated with aging.

Read More http://www.fightaging.org/archives/2012/06/popular-press-on-intermittent-fasting.php

LINKING RUSSIAN COSMISM TO MODERN THOUGHT ON ENGINEERED LONGEVITY Friday, June  8, 2012 This interview, machine-translated from the Russian, will be of interest to those who look into the history of transhumanist thought on the defeat of aging and radical life extension. It has deep roots back into the early 20th century, and one thread of these ideas was evolving through the ongoing disaster that was Russia of that century - the Russian cosmists are thought of as important predecessors to modern transhumanism, for example.

These are some thoughts and recollections of someone who was publishing and thinking on the topic in the 1960s and later; note that the Russian end of the longevity science community are far from shy when it comes to talking about physical immortality as the end goal of medicine.

Read More  http://www.fightaging.org/archives/2012/06/linking-russian-cosmism-to-modern-thought-on-engineered-longevity.php

IMPLICATING STEM CELLS IN HARDENED ARTERIES Thursday, June  7, 2012
Via EurekAlert!: "For the first time, we are showing evidence that vascular diseases are actually a kind of stem cell disease.

It is generally accepted that the buildup of artery-blocking plaque stems from the body's immune response to vessel damage caused by low-density lipoproteins. Such damage attracts legions of white blood cells and can spur the formation of fibrous scar tissue.

Read More http://www.fightaging.org/archives/2012/06/implicating-stem-cells-in-hardened-arteries.php

WAIST CIRCUMFERENCE ASSOCIATED WITH TYPE 2 DIABETES Wednesday, June  6, 2012 Here is a study that points to amount of visceral fat as a dominant contribution to the risk of age-related type-2 diabetes - a condition rarely suffered by people who successfully avoid putting on weight over the years - something that doesn't just happen, but requires exercise and a sensible approach to diet and lifestyle.

Read More http://www.fightaging.org/archives/2012/06/waist-circumference-associated-with-type-2-diabetes.php

TESTING TREATMENT OF EMPHYSEMA WITH LUNG STEM CELLS Tuesday, June  5, 2012 Via EurekAlert!: "When autologous (self-donated) lung-derived mensenchymal stem cells (LMSCs) were transplanted endoscopically into 13 adult female sheep modeled with emphysema, post-transplant evaluation showed evidence of tissue regeneration with increased blood perfusion and extra cellular matrix content. Researchers concluded that their approach could represent a practical alternative to conventional stem cell-based therapy for treating emphysema.

Read more http://www.fightaging.org/archives/2012/06/testing-treatment-of-emphysema-with-lung-stem-cells.php

EXTENDING LIFE IN FLIES VIA PINK1 OVEREXPRESSION Monday, June  4, 2012
Researchers became interested in the Pink1 gene and its protein product because mutations in it are associated with a form of Parkinson's disease. Pink1 appears to be important in mitochondrial quality control: it is a part of the machinery that ensures damaged mitochondria can be effectively destroyed.

Regular readers will know that an accumulation of damaged mitochondria is an important contribution to aging, so it should is perhaps not surprising that boosting levels of Pink1 extends life, here demonstrated in flies.

Read More http://www.fightaging.org/archives/2012/06/extending-life-in-flies-via-pink1-overexpression.php

AN INTERVIEW WITH SONIA ARRISON Monday, June  4, 2012 http://www.fightaging.org/archives/2012/06/an-interview-with-sonia-arrison.php
Over at the IEET blog, a video interview: "Sonia Arrison is the author of "100 Plus: How the Coming Age of Longevity Will Change Everything, from Careers and Relationships to Family and Faith."

In this video, Sonia discusses: how and why she got interested in technology in general and transhumanism and regenerative medicine in particular; how science and technology will allow us to live longer and healthier lives; the most common objections against increased longevity; the implications thereof on major religions; cryonics; her take on the technological singularity and our chances of surviving it; the fact that we cannot simply sit down and wait for longevity to happen." As noted, the future isn't a conveyor belt automatically bringing us better medicine and extended healthy life: every advance has to be advocated, funded, and built by someone. If too few people are working on longevity science, then rejuvenation biotechnology will not be developed in time.

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