Healthy Life Extension
œOlder and Uglier¦ or Not?
Dear Future Centenarian,
A close friend has a very funny line when people ask him how he is. He fires back, œolder and uglier.
However, he™s neither old nor ugly. But he will be if nothing changes. So will you. So will I. And so will everyone else including every supermodel you see on magazine covers.
I don™t mean to say there aren™t lots of attractive elderly people. There are. But they œlook good for their age. Can you honestly say an aging supermodel looks as good as she did at the height of her career? And I have yet to see an attractive supercentenarian (110 or older).
There are tons of world-class athletes over the age of 60. But they are world-class in their respective age groups. How many NBA players do you see in their 40™s? I just looked it up. Three. They are all exactly 40. And two of them ride the bench.
So am I saying your physical future is grim? Not at all. I™m just reminding you how things are today.
What™s our destiny? It may be older and uglier, just like our ancestors. But we have a fighting chance for œyounger (biologically) and sexier. All it takes is œwork.
So what else is new?
Everything worth having takes work. At least on someone™s part. You may inherit a bunch of stuff that™s worth having. But someone before you worked for it. And for those of us who weren™t born rich, we™re painfully aware of the work it takes to not only thrive¦ but to survive.
Then here™s your work assignment:
- Take care of yourself. I can™t remind you too often. Amazing things are happening in research labs all over the world. Don™t let bad habits prematurely age and kill you when you could be close enough to tomorrow™s emerging breakthroughs to be able to take advantage of strong rejuvenating therapies.
- Monitor your thoughts¦ and your words. Our bodies react to them. Positive thoughts and words reinforce every cell in your body. Negative thoughts and words do the opposite. This is well-documented. Comments and thoughts like œolder and uglier get imbedded in your subconscious and take you in the opposite direction of your wellness and longevity goals.
- Consider cryonics. Not all of us will make it, and cryonics is the only lifeboat available today. This hardly takes any work at all. See www.alcor.org.
- If you can afford it, invest in promising life extending technologies.
- If you can™t afford to invest, enlighten your friends who can.
We may not be supermodels or star athletes today, but I™ll let you in on a little secret.
When rejuvenating technologies mature, you won™t just be a younger version of yourself. You™ll be better. Smarter, Stronger and Sexier. Yep. We™ll be enhanced. Improved if you want to be.
And your future could very well be open-ended.
No guarantees, but an excellent chance. Isn™t that worth fighting for?
LATEST HEADLINES FROM FIGHT AGING!
A LOOK AT THE AGING LIVER Friday, March 22, 2013
This paper examines some aspects of aging in the liver, giving a general review in the course of getting to a discussion on immune system changes that occur in aging and their influence on the liver.
Note the importance of a buildup of unwanted protein byproducts inside liver cells, something that occurs due to the progressive failure of cellular housekeeping components known as lysosomes.
COMMENTS ON RECENT RESEARCH RELEVANT TO COMBATING AGING Friday, March 22, 2013
Commentary on various recently published research relevant to the SENS view of biotechnology to repair and reverse aging appears as an occasional feature at the journal Rejuvenation Research.
The latest is open access, so take a look at the PDF format paper, containing commentaries such as this one on a method of wrapping enzymes in polymer nanocapsules to ensure their delivery to specific locations within cells or the body:
CONSIDERING LONGEVITY, AGING, AND MEDICAL SCIENCE Thursday, March 21, 2013
An open access review on the topic of aging and longevity, largely focused on mainstream work aimed at producing ways to gently slow aging by metabolic manipulation:
"Aging drives disease. Nearly every major killer in developed countries shares a common feature: your risk of getting the disease increases dramatically as you get older.
AN UPDATE ON TRIALING ENGINEERED T CELLS AGAINST LEUKEMIA Thursday, March 21, 2013
Following on from research noted last year: "Genetically engineered immune cells can drive an aggressive type of leukemia into retreat, a small clinical trial suggests.
FURTHER INVESTIGATION OF DEER ANTLERS Wednesday, March 20, 2013
One lesser branch of regenerative medicine is involved in searching the animal kingdom for examples of potent regeneration and seeking to understand the mechanisms involved.
For example, there is the quest to discover whether the potential for salamander-like organ and limb regeneration, observed in many lower species, lies dormant in mammals by virtue of being an ancient process, evolved long ago and shared across most species.
A POSSIBLY IMPORTANT FINDING IN ALZHEIMER'S RESEARCH Wednesday, March 20, 2013
This has the look of something that might lead to an intermediary therapy for Alzheimer's disease, one that allows patients to better function despite beta amyloid build up - but it will be compensatory only, and won't solve the underlying damage and dysfunction of aging that causes beta amyloid to accumulate in the first place.
PUBLICITY FOR THE 2045 INITIATIVE Tuesday, March 19, 2013
Some press for the 2045 Initiative: " Russian multi-millionaire is targeting the business community to raise money to fund a project that aims to make immortality a reality by 2045.
It may sound like something straight out of a science fiction novel, but Dmitry Itskov, a 35-year-old media mogul, is seeking investors to fund research for technology that will make eternal life possible by transferring human consciousness in an artificial form to avatars (robotic bodies).
AN INTERVIEW WITH DAVID ETTINGER Tuesday, March 19, 2013
An interview on the topic of cryonics, the low-temperature preservation of the body and brain following death.
This aims to preserve the brain's fine structure - where the data of the mind is stored - so as to enable a chance at the development of future technologies to restore that individual to life: "Cryonics is based on a bet about the future, that technology will advance.
A LOOK AT HALTING OR REVERSING THYMIC INVOLUTION Monday, March 18, 2013
Left to its own devices, your immune system supports a fairly fixed upper limit of T-cells, and the fraction of those cells that can respond effectively to new threats, or patrol the body to destroy senescent or precancerous cells, declines with age.
On the one side ever more T-cells become specialized in futile attempts to deal with persistent but otherwise not terribly threatening viruses such as CMV, and thus become useless for other activities. On the other side,
A REVIEW ON THE TOPIC OF MICROGLIA IN AGING Monday, March 18, 2013
Microglia are immune cells of the central nervous system (CNS).
As is the case for the rest of the immune system, they are involved in the rising levels of chronic inflammation that accompany aging, inflammation that contributes to the development of neurodegenerative disease.