Healthy Life Extension
Major Drug Breakthrough?
posted on November 13th, 2012
Dear Future Centenarian,
So many disciplines contribute to extending healthy lifespans. This includes rational drug development, not necessarily designed to extend lives but often to keep diseases from killing you prematurely while reducing or eliminating dangerous side effects.
Enter TNI BioTech, Inc (TNIB). This is a biotech company combating fatal diseases through activating and mobilizing the body's immune system using their patented immunotherapy. Their products and immunotherapy technologies are designed to harness the power of the immune system to improve the treatment of cancer, infections such as HIV/AIDS, chronic inflammatory diseases, and autoimmune diseases.
Their technology, therapies and patents, will be used to treat a wide range of cancers, HIV/AIDS and infectious disease. One of the therapies involved in clinical trials in China involve immunotherapy that works by isolating a patient's lymphocytes (a type of white blood cells) and then incubating them together with Methionine Enkephalin (MENK) in an enriching external incubation system.
After incubation the patient's lymphocytes are re-infused back into the patient where they combat and destroy tumor cells. However, even though Management considers any condition that results in altered-immune response a target for investigation, the Company will most likely pursue additional investigations for LDN and MENK as a valuable candidate in the treatment of the following:
- Autoimmune states such as rheumatoid arthritis and multiple sclerosis;
- As an adjunct to antibiotics in the treatment of infectious diseases;
- In cancer patients undergoing chemotherapy, radiation treatments or surgery;
- Patients with AIDS, in combination with retroviral drug therapy; and
- In wound healing or herpes viral infections.
Immunotherapy presents a number of potential advantages over approved cancer treatments. The traditional tools for treating cancer have been around for years, radiation since the 1800, chemotherapy after World War I and surgery. All of these treatments are based upon destroying the cells either by damaging their DNA, selective toxicity or removing them. All of these therapies have a high order of side effects.
Immunotherapy goal is to treat the disease by avoiding the necessity for these traditional treatments.
The immune system is a diverse one with three major biological functions, that is (1) immune defense which works against infectious organisms such as bacteria, viruses, fungi, parasites; (2) immune homeostasis which works to remove senescent cells and debris; and (3) immune surveillance to clear mutated cell or cancer cell.
Researchers discovered that the principal cells in the immune system that attacked viruses and tumors were Macrophage, DC cells, T cells, NK cells, NKT cells and Gammadelta T cells. These cells originate in bone marrow and play functions in peripheral blood or immune organs.
The most important participant in the immune response is lymphocytes. These cells develop in the bone marrow and are released into general circulation.
One of the most significant medical advances in the past twenty years is the discovery of the hormones of the immune system, known as "cytokines. Cytokines are small proteins or polypeptides produced by certain body cells that interact with other cells of the immune system in order to regulate the body's response to disease or other disorder.
Clinically, these cytokines have been found to be useful in stimulating the immune system and in treating viral infections such as HIV/AIDS, hepatitis as well as in numerous types of cancers.
Two of the most important compounds to come out the current research for TNIB are LDN (Low Dose Naltrexone) and MENK (Methionine Enkephalin). Both LDN and MENK in a combinational way are proven immune-enhancing drugs with synergism. They boost the immune system by increasing the T and NK cells in the body, thereby activating its own natural defenses.
TNIB scientists have published strong articles proving that MENK plays a very important role in immune restoration in 21 cancer patients or cancer patients after chemotherapy without side effects, and that MENK showed more advantages in boosting the human immune system than either interferon or interleukin-2.
Their research results indicate that MENK at suitable doses boost the immune system through:
- Increasing proliferation and functional activities of T cells, which will play a role in anti-virus and anti-tumor activities.
- Increasing maturation of dendritic cells, which will initiate and intensify T cell responses.
- Increasing secretion of cytokines which will amplify the T cell response and mediate interaction among immune cells, forming a balanced immunity.
- Increasing functions of macrophages, resulting in concerting cellular immunity through secreting a set of cytokines.Â
- Increasing activity of NK cells, which will kill cancer cells.
Based on these findings they have developed new therapies. Those therapies are especially important when the patient's immune system is compromised due to either treatment, or diseases that can initially prevent an adequate cellular response.
Some of the treatable conditions are MS, HIV/AIDS, Parkinson™s, Inflammatory Bowel Disease, Crohn™s as well as general immune system modulation. http://www.tnibiotech.com
Free Stem Cell Presentation Alert
Bryant Villeponteau, Ph.D. the formulator of Stem Cell 100 will give a powerfully brief presentation about the Centagen Adult Stem Cell Therapy Breakthrough on Thursday, November 15, at 6:00 PM Pacific Time (9:00 PM Eastern Time). He will also take questions. Dr. Villeponteau is one of the world's foremost authorities on longevity and anti-aging.
To participate from the United States, call toll free (877) 526-1243 and enter the pin code 9769863# when prompted. To join the call outside the USA, call the international toll access number (650) 425-7104 and use the same pin code as above. For international calls you can save the long distance charges by using SKYPE. Questions may be asked by phone after or emailed to firstname.lastname@example.org by Thursday morning.
LATEST HEADLINES FROM FIGHT AGING!
WORK ON BETTER UNDERSTANDING OXIDATIVE DAMAGE IN AGING Friday, NovemberÂ 9, 2012
Oxidative stress is a term you'll see a lot when reading the literature of aging research. The more reactive oxidant compounds there are in a cell, the more they will react with important proteins, modifying them and thus causing cellular machinery to run awry or require repair.
Aging is characterized by rising levels of oxidative stress, caused by things such as increased presence of metabolic byproducts that are ever more inefficiently removed, accumulating damage to mitochondria, and so forth.
TOWARDS TISSUE ENGINEERED LARGE INTESTINES Friday, NovemberÂ 9, 2012
Last year a research group demonstrated that they could build tissue engineered sections of small intestine in mice. That same group is also working on producing structures of the large intestine using human cells, and here is an update on their progress:
LOWER VITAMIN D LEVELS CORRELATED TO HUMAN LONGEVITY Thursday, NovemberÂ 8, 2012 This research result is noted because it stands in opposition to the present consensus on vitamin D and long term health in humans; the evidence to date supports a correlation between higher levels of vitamin D, a lower risk of age-related disease, and a longer life expectancy.
But here we see the opposite result.
HYPOTHESIZING A LINK BETWEEN TASTE RECEPTORS AND LONGEVITY Thursday, NovemberÂ 8, 2012
Since calorie intake has a comparatively large impact on natural variations in life expectancy, any genetic difference that systematically reduces calorie intake in some way should be correlated with increased longevity.
So how about differences in the genes that determine taste? Here researchers search for signs of that correlation:
SOME VISIBLE SIGNS OF AGING REFLECT BIOLOGICAL AGE Wednesday, NovemberÂ 7, 2012
As one might expect, some of the easily measurable, more visible signs of aging tend to reflect a correspondingly greater risk of age-related conditions. Aging is a body-wide process, after all.
Different people age at modestly different rates, predominantly due to lifestyle choices involving diet and exercise these days, now that the burden of infectious disease is greatly reduced.
QUANTIFYING GAINS IN LIFE EXPECTANCY CORRELATED WITH EXERCISE Wednesday, NovemberÂ 7, 2012
In recent years a number of studies have tried to put numbers to the gains in life expectancy that might accompany exercise.
Here is another: "In pooled data from six prospective cohort studies, the researchers examined associations of leisure-time physical activity of a moderate to vigorous intensity with mortality.
COMPRESSION OF MORBIDITY THROUGH PHYSICAL ACTIVITY Tuesday, NovemberÂ 6, 2012
Compression of morbidity is a hypothesis suggesting that advances in medical science are causing, or will cause, a compression of the terminal period of frailty, illness, and disability at the end of life, squeezing it into an ever-shorter fraction of the overall human life span.
In colloquial use compression of morbidity is often spoken of as a practical goal by medical researchers who do not wish to talk openly about extending human life for political or funding reasons.
THE MECHANISM OF BLIND MOLE RAT CANCER IMMUNITY Tuesday, NovemberÂ 6, 2012
Blind mole rats, like naked mole rats, do not appear to suffer from cancer - an aspect of their biology that probably drives more research interest at the moment than their exceptional longevity.
The cancer suppression mechanism in naked mole rats has been explored in recent years, but here researchers discover that blind mole rats have evolved a different method of achieving the same end:
LIFESTYLE CHOICES AND THE PACE OF AGE-RELATED MEMORY DECLINE Monday, NovemberÂ 5, 2012
Longitudinal studies generally show the anticipated results when it comes to physical activity and age-related decline - if you are more active, you tend to exhibit a slower pace of decline.
Education, intelligence, and wealth are also correlated with longer life and slower onset of frailty and disability, but unlike physical activity it is less clear as to what the root causes of these correlations might be:
ANOTHER EXAMPLE OF A MITOCHONDRIALLY TARGETED ANTIOXIDANT Monday, NovemberÂ 5, 2012
Mitochondria, the powerplants of the cell, generate damaging reactive oxygen species as a side-effect of their operation.
Unfortunately, they are vulnerable to those very same reactive compounds, and some forms of resulting damage to proteins and genes can create dysfunctional cells that contribute to degenerative aging. The longer you live, the more of these dysfunctional cells you have, and the larger their harmful effects.