Healthy Life Extension
posted on February 11th, 2013
Dear Future Centenarian,
What do you think this number signifies?
The dollars spent in the US on healthcare in a month? No. We actually spend twice that amount each month on a broken healthcare system.
How about the amount we think it might take to œcure aging? Nope. We calculate we can do it for less than $5 billion.
The number of times the average human heart beats in a lifetime? Not even close. But we™re working on it.
The answer is¦
Tom Feltenstein says anthropologists tell us a hundred and seven billion people were born in all of our history.
One hundred billion humans already lived and died.
Do you know how special you are? You have a unique opportunity. You have a chance for open-ended youthful life. They don™t. One hundred billion hearts have beaten and stopped. Seven billion beat today. Think of the diversity. A hundred and seven billion people, no two quite the same. For most, their lives™ chapters have closed.
But for the seven billion of us who are still here, it's our opportunity. It™s our turn to laugh and cry, our turn to love and be loved, our turn to dream and to make those dreams come true, our chance to keep sharing our diversity with the world”possibly for much longer than any of those 100 billion ever imagined.
The chance to have the opportunity we have now, to have it and squander it, is beyond tragic.
This is an extraordinarily unique, precious, and rare opening. And it's yours. This is your life we're talking about. And you can do anything you'd like with the rest of it, including energizing and extending it.
You have that power. And the good news”the phenomenally good news”is that when it comes to manifesting change, it™s easier and more timely than most think.
LATEST HEADLINES FROM FIGHT AGING!
AN INTERVIEW WITH JUDITH CAMPISI Friday, February 8, 2013
Scientific American interviews Judith Campisi, a member of the SENS Research Foundation's scientific advisory board and a noted figure in the aging research community.
You'll note that her views are fairly conservative, much closer to the mainstream of longevity science than to SENS, however: "[SciAm]: Why is it so hard to figure out what causes aging? [Judith Campisi]: In many ways we already know what causes aging.
PARKINSON'S DISEASE AS LOCALIZED GARBAGE CATASTROPHE Friday, February 8, 2013
Alpha-synuclein is associated with Parkinson's disease (PD), and is believed to play a central role in the mechanisms that cause the destruction of dopamine-generating neurons, and thus the pathology of the condition.
Here, researchers dig deeper into the processes involved:
AN ACTUARIAL OVERVIEW ON HUMAN LONGEVITY AND MORTALITY Thursday, February 7, 2013
When you look at the vast sums of money involved, one might argue that the actuarial community has a greater incentive to understand aging than the aging research establishment does - billions of dollars rest on the degree to which predictions of future human longevity match up to reality.
Unfortunately for the actuaries (and the rest of us) that future is very uncertain. We stand at a cusp in biomedical research, an era of rapid progress in fundamental biotechnology, and one in which great leaps forward in application may or may not happen at any time.
A POPULAR SCIENCE ARTICLE ON THE STUDY OF THE AXOLOTL Thursday, February 7, 2013
From the Australian press, an example of one of a number of research groups that are studying the axolotl with an eye to mapping the mechanisms that drive their exceptional regenerative prowess:
"They are masters at regenerating their own limbs, tails, jaws, retina and heart. They can recover from spinal cord and brain injury and can easily tolerate organ transplants. And to top things off, they don't get cancer. Meet the axolotl, otherwise known as the Mexican walking fish.
TELOMERE LENGTH AS BIOMARKER OF SOMATIC REDUNDANCY Wednesday, February 6, 2013
A paper of relevance to the reliability theory view of aging: "Biomarkers of aging are essential to predict mortality and aging related diseases.
Paradoxically, age itself imposes a limitation on the use of known biomarkers of aging, because their associations with mortality generally diminish with age. How this pattern arises is however not understood.
BEING OVERWEIGHT IS HARMFUL AT ALL AGES, IN NO WAY PROTECTIVEÂ Wednesday, February 6, 2013
Researchers here argue that flawed data led to some scientists to conclude that being overweight is less harmful to long-term health than it in fact is:
"Obesity kills, giving rise to a host of fatal diseases. This much is well known. But when it comes to seniors,
CHROMATIN AND TRANSPOSONS IN SENESCENT CELLS Tuesday, February 5, 2013
Senescent cells have removed themselves from normal operation and really should be destroyed, either by their own programmed cell death processes or by the immune system.
Senescent cells accumulate with age, however, and while in place cause harm to surrounding tissues.
GENE COPY NUMBER VARIATIONS ASSOCIATED WITH LONGEVITY Tuesday, February 5, 2013
One imagines that genetic copy number variations between individuals will prove to be much like other small differences in DNA, in that there are many tiny contributions to longevity, and it is hard to find consistent results in different study populations.
"Copy number variations (CNVs) are rare losses and gains in DNA sequences that have been importantly implicated in the pathogenesis of various neurodevelopmental and psychiatric diseases.
THE PROXIMAL CAUSE OF AGING FROM THE POINT OF VIEW OF THE PROGRAMMED AGING CAMP Monday, February 4, 2013
I noted a review paper a few months back that considered the proximal cause of aging in terms of the evolution of cellular damage versus damage repair mechanisms.
That aging is caused by an accumulation of certain forms of molecular and cellular damage is the dominant paradigm at present, though there is always debate over which forms of damage are primary, which secondary, and which important over a human life span.
THE FIRST PERSON TO LIVE TO 150 HAS ALREADY BEEN BORN Monday, February 4, 2013
Wagering on the proposition that the person who will first reach 150 years of age is already alive is no wager at all, really.
It's a very safe bet that at some point in the next century the medical technologies needed for significant human rejuvenation will be developed. The risky bet is on whether it will happen soon enough for those of us in mid-life now - that will take much more advocacy, public enthusiasm, and rapid growth in research funding than has so far emerged.