Healthy Life Extension
How Anyone Can End a World in an Instant
Dear Future Centenarian,
I recently watched a World War II documentary. There was lots of graphic footage, including film of victims being executed by single shots to the head¦ thus instantly ending their worlds.
Imagine, a whole lifetime of experiences, education, wisdom, relationships and consciousness forever vanishing in a split second.
Consider the unknown loss to humanity which that single victim might have delivered had he or she lived. Multiply that by the 15 million Jews, Poles, Russians, Serbs, Czechs and others who Hitler™s Nazis exterminated. How many Nobel Laureate™s, scientists, business titans, inventors and great statesmen never lived to fulfill their destinies? Then add the sixty million plus slaughtered or starved by Mao, Stalin and Tojo. And this was only at the hands of four dictators during a forty year span¦ and does not include the millions of young soldiers killed in battle.
How could the social and economic losses to the world ever be calculated? The undiscovered products and technologies can barely be imagined and could be worth trillions to the world™s economies. How could the losses to their friends and families ever be determined? And the injustice to those millions of no longer existing individuals is beyond comprehension.
We tend to become more desensitized to such horrors as the numbers mount. Maybe they seem too distant and abstract. Local, current individual tragedies impact us harder, especially when they strike close to home.
Although my witnessing the shots to the heads was separated by 70 years and 7,000 miles, it had a dramatic effect on me. Some of the thoughts that instantly flooded my mind as their heads recoiled “ and before their limp bodies hit the ground “ were stated in my second paragraph above.
Then my thoughts seamlessly transitioned to the horrors of death from aging. People don™t seem to consider those same losses as 100,000 œold people expire every 24 hours. 37 million deaths from aging every year is a big number. Too big for most to be sensitized to it. Too remote unless it™s a loved one. And too œnatural to even think of doing anything about it. But I agonize over it every day. When I read of a notable person™s death, it™s more than passing news or a œtoo bad reaction to me. It™s a never-ending reminder to eliminate life™s closing chapter once and for all.
A big hurdle is raising funds for aging research. In addition to other challenges such as lack of believability in the prospects of curing aging, people don™t plan far enough ahead to avoid conditions that they perceive to take place many years in the future, let alone decades. Their concerns are the œHere and Now. Break a toe, and they™ll drop everything to ease the pain. But take steps to avoid suffering and death from aging in the indefinite future? Forget it. It™s too remote. There™s that important Board meeting to plan for and the vacation decision to make.
There have been some recent discussions in the life extension community of other reasons behind the lack of funding for research. Most agree that once about 10% of the population understands the possibilities of ending aging as we know it, then we would have reached the tipping point that will trigger the funding needed to finish the job. If we all do just a bit to educate our circles of friends and associates, we™ll reach that 10% sooner rather than later.
Meanwhile, funding a couple of key technologies will accelerate our success. And of course taking steps on your personal level to stay healthier longer, positions you to profit from tomorrow™s aging breakthroughs.
Latest Headlines from Fight Aging!
Mass Production of Patient-Specific Cancer-Targeting T Cells - Monday, August 12, 2013
Infusions of massive numbers of immune cells is a promising strategy for treating many conditions, as well as being something that would probably benefit any old person as a periodic compensation for the decline in the aging immune system. The technologies to enable this sort of therapy are falling into place.
An Example of the Importance of Mitochondrial Membrane Composition - Monday, August 12, 2013
The membrane pacemaker hypothesis suggests that longevity is heavily influenced by the composition of mitochondrial membranes, and thus their resistance to oxidative damage.
The details of mitochondrial structure and operation correlate strongly with variations in longevity between species, and minor genetic variations between individuals within a species may also correlate with natural variations in longevity, though the evidence for that is less compelling. Damage to mitochondrial DNA is implicated as one of the root causes of degenerative aging, however, and issues with mitochondrial function show up in many of the common age-related diseases.
That mitochondria are so influential in aging means that we should place a high priority on the development of means to repair and replace mitochondria in old tissues, and thus remove whatever contribution to degenerative aging is caused by this damage. Here is a little more evidence that supports the membrane pacemaker hypothesis.
The Most Dangerous Pessimists are Those Who Think Themselves Optimists - Tuesday, August 13, 2013
A little while back a mainstream media entity published a discussion on longevity between Aubrey de Grey of the SENS Research Foundation, an organization working on the foundation for rejuvenation biotechnology, and Walter Bortz, a long-time advocate for a better approach to health and aging, but a skeptic on the development of new and radically more effective ways to intervene in the aging process.
This is a later opinion piece in which Bortz comments on the discussion and de Grey replies in the comments.
As Expected, Health is About as Heritable as Longevity - Tuesday, August 13, 2013
Measures of health in old age and measures of mortality and longevity should all stem from the same root causes: the state of cellular damage, the integrity of repair systems, decline in function of organs, and so on. So if one of these general measures is shown to be inherited to a given degree, you'd expect the rest to be similarly heritable.
Curing Leukemia in Mice With Non-Replicating Viruses - Wednesday, August 14, 2013
Researchers here demonstrate a way to greatly increase the number of cancer-targeted viruses that can be safely infused into a patient. By disabling the ability of the virus to self-replicate they prevent it from causing dangerous side-effects.
Why Do Old Flies Die? - Wednesday, August 14, 2013
Here is an interesting view on the process of final decline and fatal systems failure due to damage and maladaptive responses to damage that occurs at the end of aging.
SENS6 Conference Press Release - Thursday, August 15, 2013
The sixth Strategies for Engineered Negligible Senescence conference will be held in September, the latest in a series of conferences devoted to rejuvenation biotechnology, building the means to reverse aging.
Targeting Redox Biology to Reverse Mitochondrial Dysfunction - Thursday, August 15, 2013
Mitochondria are the power plants of the cell, generating chemical fuel stores that can be used to power cellular processes. They are important in aging, and this has a lot to do with the generation of reactive oxygen species (ROS) that happens as a side-effect of their operation.
Researchers have shown that benefits to health and longevity can be realized in laboratory animals by targeting antioxidants to mitochondria in order to soak up some ROS before they cause harm. Other research focuses on repairing the damage that mitochondria inflict upon themselves this way, so as to stop it from contributing to degenerative aging.
Another Way to Improve Memory in Old Mice - Friday, August 16, 2013
In recent years researchers have demonstrated a number of ways to improve memory in old laboratory mice. Here is another.
A Short Overview of 3-D Printing in Tissue Engineering - Friday, August 16, 2013
Technologies derived from rapid prototyping and 3-D printing will likely play an important role in the future of tissue engineering, just as they are coming to do in many fields.
Read More https://www.fightaging.org/archives/2013/08/a-short-overview-of-3-d-printing-in-tissue-engineering.php
DISCLAIMER:Â News summaries are reported by third parties, and there is no guarantee of accuracy. This newsletter is not meant to substitute for your personal due diligence and is not to be taken as medical advice. For originating report, please see www.fightaging.org/
David A. Kekich
Maximum Life Foundation
"Where Biotech, Infotech and Nanotech
Â Â Â Â Meet to Reverse Aging by 2033"