Healthy Life Extension
Fascinating Holiday Excursions
posted on January 2nd, 2013
Dear Future Centenarian,
Holiday Party #1
On December 20th, we attended the annual SENS Foundation End of Year Event.
Aubrey de Grey founded SENS Foundation about four years ago, and he has made amazing progress since. Aubrey started developing SENS (Strategy for Engineered Negligible Senescence) in June, 2000 at Maximum Life Foundation™s first conference. Since then, he has become somewhat of a rock star because of his high international media profile as an advocate for extreme life extension.
More importantly, his strategy may save your life and pave your path to open-ended youthfulness.
In essence, SENS takes an engineering approach to aging. The rationale being that it will easier to repair aging damage if it™s caught in time rather than waiting for extremely complex interventions to slow, stop or reverse it. SENS makes sense. It withstood criticism and strict scrutiny by some of the world™s leading gerontologists.
You can learn more at http://sens.org, and you can get a summary in Smart, Strong and Sexy at 100?
Aubrey™s presentation was extremely encouraging and impressive. SENS Foundation already supports research projects at 12 major universities as well as its own lab. The party was fun too with lots of bright people to mingle with, scientists and others.
Holiday Party #2
This one was totally different and strictly social.
A friend and supporter of some of MaxLife™s initiatives invited me to an incredible party at his Malibu mansion. A few hundred people attended, including lots of celebrities. Every single one was fascinating, and they all looked great.
I did not see or talk to a single one who did not seem fit and look youthful. All, or nearly all, were into health and wellness. Not one was overweight. (In fact, I didn™t notice even one obese person out of the hundreds who attended.) None smoked.
You and I have one thing in common with all the celebs. No matter how much money, power, celebrity, good genes and good lifestyle habits you have, your aging clock subtracts 24 hours from your remaining time day in and day out. Nobody escapes.
We can extend our lives with what we know now. But aging is the great equalizer. It will make us all eventually bite the dust¦ until we put an end to it.
It breaks my heart seeing it happen to the stars I grew to love as a child and as a young adult. They seemed bigger than life. But as the years passed, so did too many of them.
What lost treasures! Now that we finally know how to control aging, how many more will we lose before we attract enough resources to kill death from aging?
When we finally learn to age without aging, we™ll look back (those of us who are left) on today and wonder why, in spite of our vast resources, we didn™t put even the tiniest fraction to work against aging. We™ll wonder why so much was spent on researching aging-related diseases and in keeping people alive in agony for extra days, weeks and months while ignoring the cause of most diseases.
Cure aging and be entertained by your favorite stars as long as you want. Cure aging, and you™ll have time to do almost anything you want.
LATEST HEADLINES FROM FIGHT AGING!
THE EMERGENCE OF BIOGERONTOLOGY AS A DISCIPLINE Friday, December 28, 2012 http://www.fightaging.org/archives/2012/12/the-emergence-of-biogerontology-as-a-discipline.php
Here is a review paper that looks back at the recent history of biogerontology as a field of study, noting the struggle with long-held perceptions of fraud associated with the intersection of aging and medicine:
CONSIDERING THE BUSINESS OF REGENERATIVE MEDICINE Friday, December 28, 2012
Looking back at past commercial development in medicine is a fair way to manage expectations for present efforts to bring therapies to the clinic.
The short version of the story is that there are certainly cycles in which expectations outpace results, but those results arrive in the end: "Like many advanced technologies, the field of regenerative medicine has gone from boom to nearly bust to boom again in the span of just 30 years.
REVIEWING MITOCHONDRIAL ACTIVITY AND LONGEVITY Thursday, December 27, 2012
Mitochondria are the power plants of your cells, responsible for creating the energy stores that are used to power cellular operations.
Mitochondrial composition is an important determinant of longevity, and accumulating mitochondrial damage - self-inflicted in the course of the operation of metabolism - is one of the root causes of aging.
Here researchers review what is known of mitochondrial decline in aging, and the ways in which mitochondrial function can be altered to extend life in laboratory animals:
USING STEM CELL TRANSPLANTS TO BOOST NEUROGENESIS Thursday, December 27, 2012
Failing neural plasticity, the ability of the brain to adapt and continue creating new neurons, seems to be important in aging.
Here researchers investigate the ability of some forms of stem cell transplant to boost the pace of the creation of neurons:
BLOCKING MIR-15 BOOSTS REGENERATIVE CAPACITY IN THE HEART Wednesday, December 26, 2012
One important outgrowth of stem cell research is the search for ways to manipulate existing cell populations into greater feats of regeneration.
Eventually, it would be hoped, the research community can gain sufficient control over cells in the body so as not to need stem cell transplants at all.
PROGRESS IN THERAPIES FOR RETINITIS PIGMENTOSA Wednesday, December 26, 2012
Therapies for several forms of degenerative blindness have been under development for some years. Here is news of progress towards trials for two of them:
FURTHER COMMENTARY ON HYDRA LONGEVITY Tuesday, December 25, 2012
Last month the popular press was doing its normal breathless job of failing to adequately understand and present the facts in relation to research into aging and longevity. In this case it related to recent research into hydra.
These small water creatures may be ageless, or at least age very slowly, and are certainly very competent when it comes to regeneration from injury, but that's about as far as it goes - it seems unlikely that profound advances immediately applicable to humans lurk in hydra biology.
SUPPRESSING THE INFLAMMASOME IN ALZHEIMER'S Tuesday, December 25, 2012
Inflammation is an important process in the progression of Alzheimer's disease, and researchers have been turning their attention to ways to manipulate inflammation as a form of treatment:
"The complex named "NLRP3 inflammasome" is composed of several proteins and plays a key role in the immune system. It resembles a fire alarm sensor that triggers a chain reaction when activated. As a result, immune cells are mobilized and substances that foster inflammation are released.
REPAIRING BLINDNESS DUE TO CORNEAL LIMBAL STEM CELL DEFICIENCY Monday, December 24, 2012 http://www.fightaging.org/archives/2012/12/repairing-blindness-due-to-corneal-limbal-stem-cell-deficiency.php
Here is an example of a stem cell therapy that is just a little advanced over established medical techniques - in effect just a more sophisticated and cost-effective version of a tissue transplant:
HEALTH EXTENSION SALONS, BAY AREA AND EXPANDING Monday, December 24, 2012
The Health Extension salons are an ongoing series of meetups in the Bay Area for people interested in supporting and advancing longevity science, associated with the energetic technology entrepreneur community there.
This sort of initiative is important, as grassroots efforts associated with this community have a way of growing and getting things done.