Longevity News Digest
Extreme Longevity Goes Mainstream
Dear Future Centenarian,Â
In case youÂ missed it, CNN™s œInside Man documentary series ran a segment Sunday evening titled œThe Future. And the œfuture topic for this show was nothing less than extreme life extension.
You might know of host Morgan Spurlock. He shot to fame by gorging himself on McDonald's three times a day to see what happens if he lived off only that¦ and he ate the largest size that workers pushed, in the now famous documentary "Super Size Me."
Where following the Super Size Me diet almost killed him, he did an about face on last weekend™s show. Not only did he chronicle his quest for longevity, but he incorporated much of what he learned into his personal life¦ and crisscrossed the country trying to find out how he could live œforever.
Now Spurlock quaffs supplements and exercises. Since shooting that episode, he has lost 25 pounds and is reversing his aging profile.
How is he doing that? No mystery if you read Smart, Strong and Sexy at 100.
For one thing, he quit eating carbohydrates. No bread. No pasta. And now, thanks to Dr. Terry Grossman, sugar is also a no-no. He says he feels better than he ever has. That doesn™t mean he doesn™t enjoy himself. He still drinks wine dinner with dinner when he wants and probably sneaks secret indulgences whenever he wants too.
The happiest life extensionists do not follow Spartan lifestyles. Remember, we want to live long¦ and also well.
The big takeaway from this program was you don™t need to be an immortality seeker to both enjoy it “ and benefit from it. It covered the gamut from a complete longevity workup followed by specific results and recommendations from Dr. Grossman to Kurzweilian never-say-die projections.
The video opened right here in S. California where people try various ways to extend their lives. In fact it was œright here where Spurlock learned from some of the masters who attended MaxLife™s annual longevity party, as well as from of some of their over the top healthy students.
Some extremists take a hundred supplements daily. And some, including yours truly, follow the Paleo diet. Some train hard. Others moderately. Movers and shakers in the cryonics community, Max and Natasha Vita-More were two featured attendees as well as œbecoming really famous sci fi author, Zoltan Istvan, and already famous super doc Lord Lee-Benner.
Lots of other notables too, including Dr. Stephen Coles who just revealed the results to me of an undercover four-year stem cell research project. He said the science could be Nobel prize caliber. I will report details soon.
The show moved from here to Denver's Grossman Wellness Center, where Spurlock has an incredibly thorough physical exam.
Then to regenerative medicine legend Dr. Anthony Atala at North Carolina™s Wake Forest University San Francisco, and on to genome hacking Cambrian Genomics in San Francisco, before interviewing Ray Kurzweil. Ray was predictably on top of his game and 100% positive that we will crack the aging code through technology.
After that, Spurlock made a pit stop in a pub to interview a virtual reality expert. Â That led him to Stanford University's Virtual Human Interaction Lab¦ where they treated him to some heart pounding experiences “ and even created a Spurlock avatar.
Finally, Spurlock™s trek led him back to S. California to USC. They treated him to incredible hologram technology where they created a Spurlock hologram. It even had Spurlock (the original) confused for a moment as to which one was which. That gave us a peek into what uploading your consciousness onto another platform might be like one of these days.
Spurlock then summed up his experience. At first a skeptic, he came away from the experience understanding how extreme life extension is definitely probable¦ and that it could be in the cards for him.
His parting words of advice were to get the most out of your life, and your time, no matter how long you might live.
Latest Headlines from Fight Aging!
TRF2 as a Potential Biomarker of Cellular Senescence - Monday, April 14, 2014
The accumulation of senescent cells with age is one of the causes of degenerative aging, as senescent cells behave badly, emitting proteins that harm surrounding tissues
Finding a way to clearly identify senescent cells is a necessary step on the path to a targeted treatment that can destroy them, using engineered immune cells, nanoparticles, viruses, or any of the other approaches to selective cell destruction that are presently under development. Much of the work towards this end is focused on p16, which seems promising but may or may not in the end prove to be discriminating enough. Here researchers are exploring a different marker of senescence.
Learning to Reverse Aspects of Cell Aging By Observing the Embryo - Monday, April 14, 2014
Adults are old, but children are young: at some point in the early development of an embryo, a collection of presently poorly cataloged processes erase the changes of aging present in the adult cells that created it.
It is probably the case that there is little in this that can be applied directly to making us live longer, as the sort of radical restructuring of cells that takes place in the developing embryo would be fatal to the much more complex adult organism. We couldn't apply this to ourselves for all the same reasons that we can't constantly renew ourselves like the tiny creatures called hydra.
Our nervous system, mind, and other complex and finely balanced processes depend on the present detailed structure of our long-lived cells, and that structure would be erased.
However, as the authors of this paper point out, there is potentially much to be learned from the embryo that could be of benefit for stem cell treatments. In this case the research community absolutely wants to be able to reverse the damage of aging in induced pluripotent stem cells (IPSCs) generated from an old patient. To a certain extent this already happens, but greater control and effectiveness is desired.
The Fragile Elderly Hip - Tuesday, April 15, 2014
Here is an open access review that looks at what is known of the proximate mechanisms that cause increasing fragility of bone with advancing age.
These are not the root causes, but it remains to be determined how exactly the laundry list of primary differences between old tissues and young tissues produces the results discussed below.
Arguably it is faster and more efficient to investigate by doing; work to reverse these primary changes in tissue samples and animals and see what happens. That is a lot easier than trying to understand the full scope of the complexity of aging, and has a much greater chance of producing meaningful therapies to halt the advance of aging in the near term.
More Evidence of the Inverse Relationship Between Dementia and Cancer Mortality - Tuesday, April 15, 2014
It is perhaps unexpected that incidence of dementia and incidence of cancer seem to have a robust inverse relationship, one that has shown up in multiple different study populations. In general we think of aging as a global phenomenon in the body keyed to rising levels of damage in all tissues: if you are farther down the road than your peers for whatever reason then you would expect a higher risk of all of the potential failure modes in the complex systems of your body.
In one sense, yes, this is true. But in some people risk of cancer rises significantly more rapidly than risk of dementia, and in others vice versa. As this study shows the differentiation in risk starts early in the progression of age-related cognitive decline.
A Decellularized Oesophagus Demonstrated in Rats - Wednesday, April 16, 2014
Researchers here make use of the process of decellularization to match a donor organ to the recipient. In the ideal procedure, donor cells are removed and the remaining extracellular matrix of the organ is repopulated with the recipient's cells, thereby eliminating most issues of transplant rejection.
The use of a donor matrix bypasses the present inability to construct a sufficiently complex scaffold for most tissues, complete with cues and guides for blood vessel formation and other structures within tissue.
A Canine Longitudinal Aging Study Proposed - Wednesday, April 16, 2014
As noted below researchers are making an effort to establish the basis for a comprehensive study of aging in longer-lived species.
Most present work on aging in mammals takes place in mice and rats, and while there are many similarities between mice and humans there are also sometimes unexpected differences in the biochemistry of aging between short-lived and long-lived species.
For example that the important types of advanced glycation end-product (AGE), which produce cross-links that accumulate in tissues over a life span to cause damage and dysfunction, turned out to be very different in rodents and humans sabotaged some of the first serious efforts to produce AGE-breaker drugs to slow or reverse this contribution to the aging process.
Public Views on the Future of Technology - Thursday, April 17, 2014
A few things are of interest in this survey, with one being that a majority of people don't like specific instances of societal change resulting from technological advances if asked about them, which isn't much of a surprise given human nature.
Another is that extended human longevity shows up as a desired goal for a larger minority than has been the case in the past - I would expect to see growth in this number when measured, given the events of the past few years. This being a survey there is little distinction made between the fantastical drawn from science fiction and the plausible drawn from science, which is unfortunate, but it is still worth a look.
A Midlife Crisis for the Mitochondrial Free Radical Theory of Aging - Thursday, April 17, 2014
Here is an open access paper that covers some of the challenges that have faced the interpretation of just how and why it is that mitochondria have an important role in the aging process.
The mitochondrial free radical theory of aging has been broadly considered, in several forms, but as for just about every theory of aging early models turned out to be too simple and straightforward. The reality on the ground is more complex, which is why you'll find a mass of data that supports this theory and another mass of data that contradicts it.
Turning Cells into Programmable Medical Devices - Friday, April 18, 2014
Targeted delivery of drugs and proteins to modify metabolism and cell behavior may in the future be accomplished by engineered cells. Cells already do a great many useful things, so why reinvent the wheel when there is existing machinery that can be adapted to new purposes?
This is a line of research with the potential to radically change the face of medicine and our own biology, leading to a future in which most of us have large numbers of enhanced and altered cells in every organ, monitoring and reacting to local conditions in order to help maintain the body against the processes of aging and disease far more effectively than our present evolved mechanisms can manage.
Is Parkinson's an Autoimmune Disease? - Friday, April 18, 2014
This is an interesting view on the later stages Parkinson's disease that seems fairly orthogonal to the present mainstream focus on Î±-synuclein and its removal.
Read More https://www.fightaging.org/archives/2014/04/is-parkinsons-an-autoimmune-disease.php
DISCLAIMER:Â News summaries are reported by third parties, and there is no guarantee of accuracy. This newsletter is not meant to substitute for your personal due diligence and is not to be taken as medical advice. For originating report, please see www.fightaging.org/
David A. Kekich
Maximum Life Foundation
"Where Biotech, Infotech and Nanotech
Â Â Â Â Meet to Reverse Aging by 2033"