Healthy Life Extension
The Most Important Person in the World
posted on August 21st, 2012
Dear Future Centenarian,
You know how to boil a frog alive, right? (Not that we want to¦)
The secret is to gradually turn up the heat. If you make it real hot, real fast, the frog will jump out of the pot. But if you turn up the heat slowly, before the frog realizes it, it will be too late, and the frog slowly dies. As aging humans, we are all slowly (and some not so slowly) being boiled alive by the ravages of time.
What if we had a major sudden breakthrough in a technology that could make possible the complete rejuvenation of a human being, turning back the clock to optimum health and youth? Allowing for MORE time with family and friends and MORE time to achieve all of the goals one dreams of?
Making super sexuality a forever thing, not just a highly-charged stage of adolescent life? Going and doing and moving like a well-oiled machine once again? Don™t you think aging billionaires, and anyone who could afford it, would make mad dashes to their checkbooks to complete the research before it™s too late for them?
We don™t have that breakthrough¦ yet! But it™s on the horizon “ just beyond our reach.
Our scientists say they KNOW how to do it, and in our lifetime. But that™s contingent on funding.
Meanwhile, the world™s 1,226 billionaires, like that ill-fated frog in the story above, are slowly being boiled alive. (In fact, Steve Forbes estimates there are actually about 3,000 billionaires.)
Why, then, aren™t they, or at least several of them, stepping up to the plate and getting out of the slowly heating œpot that will put an end to all that they now enjoy and have worked so successfully to achieve?
After all, at least 215 of them have $5 billion or more, and we estimate we might solve aging for less than $5 billion total spread over the next 16-20 years. To put it in perspective, we spend more than that in the U.S. every day on a broken healthcare system.
For one thing, a proposal to fund the necessary research is out of the scope of their business or their favorite charity(s). After all, most high achievers at that level have diverse 1) business interests, 2) charitable activities and 3) investment portfolios.
But having what we™re proposing as a focus makes little sense according to their (obsolete) guidelines. The ONE SINGLE activity that could extend all three, supporting life-extending research, better enables every other personal or business pursuit.
Let™s analyze these three:
- Business Interests “ Anti-aging is an emerging trillion dollar industry. Entrepreneurs will build enormous companies, especially those who commercialize technologies that would dramatically extend the youthful portions of our lives, let alone reverse aging.
- Charitable Activities “ We lose 100,000 people to aging every single day. Then factor in the suffering. And how about the trillions of dollars of related medical costs? Then there are the social costs of continually losing our most productive and valuable minds. Learn how to control aging and we have pretty much solved heart disease, stroke, cancer, arthritis, etc.
They™re all important diseases to solve in themselves, but solve one, and another will probably get you. If you consider aging as a cause, and it is, then the others could be considered as symptoms. In other words, what could be a more impactful charitable contribution?
- Investment Portfolios “ Nearly every billionaire is invested directly or indirectly in soft drink, fast food, tobacco, processed food or alcoholic beverage companies. Another common thread is that they have virtually zero dollars invested in companies or technologies which will keep them from being slowly boiled to death. Isn™t this seriously out of balance?
We believe that once people know about emerging technologies that could dramatically extend the youthful portions of their lives and their families™ lives, they will change the mix of their three major financial activities. No one wants to suffer and die and to see their families die when they have the power to avoid or at least delay that. And that is the proposition we are engaged in.
Even if any thought there was just an outside chance for open-ended youthfulness, they would probably be very interested in giving it a shot. And the worst thing that would happen to them is there would be slightly less money for their heirs.
Some billionaires actually get it and in fact have offered some funding. But none has made a major commitment as far as I know. And that™s tragic “ for them and for you.
This isn™t about any single person taking a plunge. On the other hand, someone who was able to single-handedly fund all the research, and completely change the world as we know it, would probably be recognized as œthe most important person in the world. Certainly preserving 37 million lives a year would be worthy of that title.
More realistically, however, the investments and donations will be spread among many. But those who step up to the plate now will be the ones who make the most impact. Every day™s delay could ultimately cost up to 100,000 lives¦ they included.
The bottom line is¦ it completely baffles me why the world stresses and becomes obsessed over their businesses while they ignore extreme life extension endeavors. Building empires, investing, new innovations, competition, distribution, regulatory nightmares, administration, human resources and other activities consume business and financial leaders.
Then around eightyish, they die. How have their activities contributed to their wellness and longevity, or anyone else™s for that matter? Except for the prospect of leaving something behind, what did it ultimately matter to them?
Please understand, I support and admire enterprise, contributions to society, a purpose of life and the commercial intricacies that enabled complex societies to develop and flourish. Without them, we would not have reached this point¦ where controlling aging is finally possible.
Suddenly, the whole world is different. Transitory pursuits will still play key roles in our economies. But transitory they are, and transitory we are as long as we focus on traditional financial and business pursuits to the exclusion of life extension.
Instead of planning on leaving a legacy, those with the financial means can now plan on LIVING their legacy if they so choose.
LATEST HEADLINES FROM FIGHT AGING!
EVERYONE SUFFERS THE DOWNWARD SPIRAL OF EXERCISE CAPACITY Friday, August 17, 2012
Other than calorie restriction, regular exercise is the most potent presently available method available to maintain health and extend life expectancy - which is actually more of a criticism of our lack of advanced biotechnology than praise for the merits of exercise.
Exercise is beneficial even for the elderly, however, and one part of the downward spiral that comes with age is that loss of strength and increasing frailty constrain the ability to exercise sufficiently vigorously to obtain its benefits. This is true even for the longest-lived humans:
MORE BLOOD VESSEL ENGINEERING Friday, August 17, 2012
Many research groups are working on building blood vessels. Here is one: scientists "have developed [an] artificial functioning blood vessel outside of the body, made from reprogrammed stem cells from human skin.
The team also saw the cells develop into a blood vessel inside the body for the first time. The new technique could have real potential to treat patients with heart disease [by] either injecting the reprogrammed cells into the leg or heart to restore blood flow or grafting an artificially developed vessel into the body to replace blocked or damaged vessels.
NANOFACTORIES TO PRODUCE AND TARGET DRUGS IN THE BODY Thursday, August 16, 2012
Another branch of targeted therapies is the design of nanofactories that can be steered to specific locations in the body and there produce proteins and other drugs in response to local conditions or external commands.
Early work in this field is underway: "Science is one step closer to producing drugs in the right place at the right time in the body, avoiding the collateral damage of untargeted treatments.
NANOPARTICLES AND RNA INTERFERENCE VERSUS CANCER Thursday, August 16, 2012
A novel form of targeted therapy under development in the cancer research community: "By sequencing cancer-cell genomes, scientists have discovered vast numbers of genes that are mutated, deleted or copied in cancer cells.
This treasure trove is a boon for researchers seeking new drug targets, but it is nearly impossible to test them all in a timely fashion. To help speed up the process, [researchers] have developed RNA-delivering nanoparticles that allow for rapid screening of new drug targets in mice.
AN IMPROVEMENT IN ENGINEERED PANCREATIC TISSUE Wednesday, August 15, 2012
From ScienceDaily: "researchers have built pancreatic tissue with insulin-secreting cells, surrounded by a three-dimensional network of blood vessels. The engineered tissue could pave the way for improved tissue transplants to treat diabetes.
The tissue [has] some significant advantages over traditional transplant material that has been harvested from healthy pancreatic tissue. The insulin-producing cells survive longer in the engineered tissue, and produce more insulin and other essential hormones.
THE POSSIBILITY OF A VACCINE FOR HEART DISEASE Wednesday, August 15, 2012
Via EurekAlert!: "Most people probably know that heart disease remains the nation's No. 1 killer. But what many may be surprised to learn is that cholesterol has a major accomplice in causing dangerous arterial plaque buildup that can trigger a heart attack. The culprit?
Inflammatory cells produced by the immune system.
THE NEXT STEP IN BUILDING A BETTER EYE PROSTHESIS Tuesday, August 14, 2012
Present prosthetic retina technology consists of an implanted electrode grid; progress is increasing the resolution by adding more electrodes to the grid. Here researchers take a different route, investigating ways to encode information such that neural cells will better process the resulting image:
"More than 20 million people worldwide become blind owing to the degeneration of their retina, the thin tissue at the back of the eye that turns light into a neural signal.
GADD45A ORCHESTRATES MUCH OF MUSCLE ATROPHY Tuesday, August 14, 2012
An important regulatory gene for muscle atrophy is identified: "We now understand a key molecular mechanism of skeletal muscle atrophy. This finding could help us find a therapy for treating muscle atrophy in patients.
The team has identified a single protein, called Gadd45a, and determined that it orchestrates 40 percent of the gene activity that ultimately causes skeletal muscle to atrophy.Â
ON BOREDOM AND RADICAL LIFE EXTENSION Monday, August 13, 2012
Some people knee-jerk against the prospect of a greatly extended healthy life by thinking of boredom - they can't imagine what they'd do with additional time. To my mind this fits well with the demographic who are ambivalent about being alive at all.
To live a longer or shorter life will always be a choice, however. You won't have to undergo the rejuvenation therapies when they are available, just as you don't have to exercise, eat less, or otherwise maintain your health today: a shorter life is right there for the taking, if you feel so inclined.
"NOT A HARMLESS PART OF THE AGING PROCESS" Monday, August 13, 2012
There is a pervasive mythology surrounding aging: that it includes many harmless changes, things that are "normal" and therefore not worthy of the attention of medicine. This is all nonsense.
All changes that happen with aging are damage-driven declines, but because the overall effect is so disastrous it can be hard to pin down and separate out the lesser components. As biotechnology improves, we will see ever more pieces of aging segmented off and named as specific diseases - but in reality it's all harmful, and the full breadth of aging should be fought against: