Birthdays are Good for You

Longevity News Digest

Funding Aging Research

"Birthdays are Good for Your Health

Dear Future Centenarian,

Studies show that those who have more birthdays tend to live longer. O

That was lesson #1 for the week.

#2 is what you eat¦ and #3 is how you move.

Rather than going into details here re #s 2 and 3, wouldn™t you rather have a personal file? All you need to do for your free report is to¦

¦Click Here

I REALLY encourage you to read this report carefully “ and then to keep it for future reference.

Look. We ARE closing in on the capability to rejuvenate the elderly. Some of us will live long enough to make it by a hair. Sadly, some will fall just a little short. Whichever group you might fall into may be largely up to you.

I wish I knew when that magical event emerges. But I don™t. No one does. We do know this simple truism. It won™t raise the dead, except for the possibilities cryonics offers.

How I envy the younger generations. They won™t have to work as hard for open-ended youthfulness. But they won™t appreciate it as much either.

For the older generations, make no mistake about it¦ survival is going to take work. A small percentage of us are working in various ways to help get these technologies developed. Raising research funds, doing the research, activism, and basically living and breathing longevity pursuits.

But ALL of those who are SERIOUS about having their clocks turned back plan their personal lifestyles toward that goal.

I™ll bet you know people who pay lip service to extreme wellness, only to wrap those same lips around a plateful of charred French fries. Actions speak louder than words. Actions can kill or cure.

You probably know that the vast majority of heart attacks, strokes and cancers are avoidable. Not all. But most. Estimates go as high as 95%. Other aging related diseases are largely avoidable too.

PLEASE. Swing the odds to your side. You don™t need to be a monk. You just need to respect your body.

The same people who pollute their bodies wouldn™t think of using anything but the highest premium gasoline and motor oil in their luxury cars. Heaven forbid you have a maintenance problem. But your most precious and most fragile machine? Most heap the kind of abuses on our personal meat bags that we would never do to the buckets of bolts that get us to our favorite fast food joint.

What are they thinking???

So here you go: Just click on Stop Aging and be Lean for Life and start on you path to super longevity today.

More Life,
David Kekich

P.S. It™s going to take some radical innovations to reverse aging. You will be interested in Zoltan Istvan™s interview by Michael Nuschke. See http://www.retirementsingularity.com/fireside-chat-with-zoltan-istvan-author-of-the-transhumanist-wager/. Zoltan is a key thought leader in the life extension community. Michael is a financial planner with a unique slant on how to plan in this age of exponential advancements.
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Latest Headlines from Fight Aging!

Molecular Tweezers Targeting Transthyretin Amyloidosis - Monday, April 28, 2014
Various forms of amyloid build up in tissues with age, forming fibrils and clumps. These are precipitates of misfolded proteins, and while the harm caused by amyloids is not fully understood in all cases they are associated with numerous specific diseases of aging.

The amyloid plaques that accompany Alzheimer's disease are perhaps the best known, for example. It is thought that the oldest people, those who live longer than 110 years of age, are largely felled in end by senile systemic amyloidosis which involves amyloids formed of misfolded transthyretin.

There is also a rare genetic disease in which this occurs early in life, called transthyretin-related hereditary amyloidosis or familial amyloidotic polyneuropathy - and as is often the case in such matters research into the rare genetic disease has more funding than research into the common age-related condition. Fortunately any potential treatment involving removal of amyloid is directly applicable to both types of condition.

Read More https://www.fightaging.org/archives/2014/04/molecular-tweezers-targeting-transthyretin-amyloidosis.php

Envisaging 3-D Printing of Replacement Cartilage Inside an Injured Joint - Monday, April 28, 2014
An ambitious form of 3-D printing is envisaged by these researchers: they want to develop the means to print out replacement cartilage tissue in place inside the body by use of minimally invasive techniques such as the introduction of a catheter threaded with the print head machinery that deposits cells and matrix materials.

Read More https://www.fightaging.org/archives/2014/04/envisaging-3-d-printing-of-replacement-cartilage-inside-an-injured-joint.php

Heat Shock Protein 25 and Naked Mole Rat Longevity - Tuesday, April 29, 2014
Naked mole rats live up to nine times longer than other similarly sized rodents and are to all appearances immune to cancer.

These facts make the species of considerable interest to researchers who study aging: what exactly are the biological mechanisms by which this longevity is achieved? So far it seems that naked mole rats are very resistant to the consequences of high levels of oxidative damage to molecular machinery within cells, and they have exceptionally good maintenance of proteostasis, the ability to keep protein levels stable over time and avoid the buildup of amyloids made up of misfolded proteins.

But there is still much to be determined of the mechanisms by which these attributes are managed. Here is a recent report from researchers involved in these investigations, focusing on cellular quality control mechanisms.

Read More https://www.fightaging.org/archives/2014/04/heat-shock-protein-25-and-naked-mole-rat-longevity.php

Clearance of Senescent Liver Cells Following Cell Transplant - Tuesday, April 29, 2014
Cellular senescence is an important topic in aging: the number of senescent cells increases with age, and they cause harm to surrounding tissues.

The research community is on the verge of being able to effectively remove these cells, however, using the tools under development by the cancer research community to target and destroy cancer cells with minimal side effects.

There may also be other ways to deal with senescent cells. The research result below was published earlier this year and makes for an interesting companion piece to a more recently published paper in which researchers showed that a method of growing large numbers of liver cells called hepatocytes via serial transplantation in mice was reversing cellular senescence along the way.

Here cancer researchers find that cell transplants into rats have a similar effect, at least for cellular senescence that is artificially induced via introduction of a mild toxin that causes DNA damage and other cellular dysfunction leading to cancer. I would have to see a similar result in old animals with natural levels of cellular senescence before becoming too enthusiastic about this.

Read More https://www.fightaging.org/archives/2014/04/clearance-of-senescent-liver-cells-following-cell-transplant.php

Investigating Salamander Heart Regeneration - Wednesday, April 30, 2014
Researchers hope that continued study of salamanders and other species with exceptional regenerative capabilities will yield results that can inform the development of regenerative treatments for humans.

Read More https://www.fightaging.org/archives/2014/04/investigating-salamander-heart-regeneration.php

Biodegradable Nanoparticles Target Brain Cancer Cells - Wednesday, April 30, 2014
The future of cancer treatment will be based upon a wide range of methodologies that selectively target cancer cells to deliver payloads that destroy only those cells. The end result will be highly effective treatments that can eliminate even metastatic cancer with minimal side effects. Here is an example of work in progress.

Read More https://www.fightaging.org/archives/2014/04/biodegradable-nanoparticles-target-brain-cancer-cells.php

Pig Extracellular Matrix as a Scaffold for Muscle Regeneration - Thursday, May 1, 2014
Mirroring some of the work taking place in the tissue engineering field with decellularized donor tissue, in which the donor's cells are removed and then the structure left behind repopulated with the recipients cells, researchers here are using extracellular matrix (ECM) material from pig tissue as the basis for scaffolds to spur regrowth in large muscle injuries.

Read More https://www.fightaging.org/archives/2014/05/pig-extracellular-matrix-as-a-scaffold-for-muscle-regeneration.php

Tissue Engineered Cartilage via Mesenchymal Condensation - Thursday, May 1, 2014
Recently researchers have made inroads in using the embryonic development process of mesenchymal condensation to generate tissue engineered teeth, or at least to show promising signs of progress along that road.

Here this same process is turned to building cartilage, a type of tissue that has proven to be very challenging to engineer. Its mechanical properties are crucial to its role in the body, and these properties depend absolutely on the small-scale arrangement of cells and extracellular matrix. Even slight differences result in artificial tissue that is just an arrangement of cartilage cells, not the real thing, and not up to the task of supporting weight in joints.

Here researchers are claiming to have generated cartilage that is sufficiently similar to natural cartilage to be a candidate for use in the clinic.

Read More https://www.fightaging.org/archives/2014/05/tissue-engineered-cartilage-via-mesenchymal-condensation.php

A New Potential Treatment for Progeria - Friday, May 2, 2014
The accelerated aging condition Hutchinson-Gilford Progeria Syndrome (HGPS) is not in fact accelerated aging, but only appears that way. It is caused by dysfunctional lamin A, a protein vital to nuclear structure in cells, and this dysfunction leads to all sorts of cellular issues and damage.

Malformed lamin A does show up in normal aging in very small amounts, but it is unclear whether or not this is significant in comparison to other causes of aging, and whether it is a primary or secondary effect. Researchers have also managed to extend life in mice by manipulation of lamins, which is intriguing but may not be relevant to either human aging or progeria as the mechanisms of action are not yet fully understood. Still, all told it seems worth keeping an eye on progress in the development of treatments for progeria.

Read More https://www.fightaging.org/archives/2014/05/a-new-potential-treatment-for-progeria.php

Extending Life in Mice With Artificially Shortened Life Spans is Rarely Directly Relevant or Useful - Friday, May 2, 2014
There are numerous examples of studies that use mice genetically engineered to suffer forms of shortened life span with the appearance of accelerated aging. One has to be very cautious in reading anything into this sort of work, however: it is rarely of any great relevance to normal aging, as it creates and then attempts to ameliorate an entirely artificial situation.

The appearance of accelerated aging is not in fact accelerated aging, but is rather often caused by mechanisms that are of little importance in normal aging. Even when the mechanisms are relevant, the overall metabolic circumstances can render it impossible to determine whether or not a partial treatment will be of any use in normal aging. The gold standard for relevance when evaluating new methods is the extension of life in unmodified mice, but unfortunately this is expensive and slow.

The publicity materials quoted below are a good example of research in animals exhibiting shortened life spans. Here scientists are investigating a protein involved in the induction of cellular senescence. As is often the case, however, from the structure of the work it is impossible to tell whether or not their drug candidate will be of any use as a treatment to lower levels of cellular senescence in normal aging and thus produce benefits such as extended health and life span. Those tests will still have occur.

Read More https://www.fightaging.org/archives/2014/05/extending-life-in-mice-with-artificially-shortened-life-spans-is-rarely-directly-relevant-or-useful.php
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DISCLAIMER:  News summaries are reported by third parties, and there is no guarantee of accuracy. This newsletter is not meant to substitute for your personal due diligence and is not to be taken as medical advice. For originating report, please see www.fightaging.org/

David A. Kekich
Maximum Life Foundation
www.MaxLife.org

"Where Biotech, Infotech and Nanotech
     Meet to Reverse Aging by 2033"



 

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