Healthy Life Extension
Declaration of Aging Independence
posted on July 10th, 2012
Dear Future Centenarian,
I quietly celebrated my favorite Holiday last Wednesday¦ The œFourth of July or œIndependence Day.
On the Fourth, I reflected on the amount of liberty that has eroded over the past two centuries, and especially the amount of control we have lost over our own bodies. Then I took liberty with the Declaration of Independence by modifying it as it might pertain to our health¦ and even our survival.
With humble apologies to our Founding Fathers, here it is:
When, in the course of human events, it becomes necessary for one people to dissolve the political bands which have connected them with our health and longevity, and to assume among the powers of the earth, the separate and equal station to which the laws of nature and of nature's God entitle them, a decent respect to the opinions of mankind requires that they should declare the causes which impel them to dismiss politically imposed regulations which cause avoidable individual and collective suffering and premature death.
We hold these truths to be self-evident, that all men are created with the potential to escape the ravages of aging, that they are endowed by their Creator with certain unalienable rights, that among these are maximum wellness and longevity, disease-free lives, liberty of their health freedom choices and the pursuit of radical lifespans.
And that they should be free to reap the benefits or suffer the consequences of their individual decisions, without interference by any governmental agency and without mandated support of any third party in the event of harmful personal choices. Each individual, acting alone or in collaboration with others shall be endowed with the right to freely seek and to offer to others, any and all information upon which he or she may rely in making such choices.
That to secure these rights, governments are instituted among men, deriving their just powers from the consent of the governed. That whenever any form of government becomes destructive to these ends, it is the right of the people to ignore, alter or to abolish it, and to pursue their own unrestricted initiatives in the pursuit of wellness and open-ended longevity.
The United States Government has obstructed the administration of optimal medical care, by throwing up regulatory barriers to innovation and implementation.
It has erected a multitude of new offices, and sent hither swarms of officers to harass our people, and eat out their substance.
It has declared itself invested with power to legislate for us in all cases whatsoever.
We, therefore, solemnly publish and declare, that we individuals are, and of right ought to be free and independent persons; that we are absolved from all allegiance to any form or jurisdiction of government that hastens our death and that restricts our pursuit of health freedom to be totally dissolved; and that as free individuals, we have full ownership and power over our own bodies, and to do all other acts and things which free individuals may of right do to ensure maximum wellness.
And for the support of this declaration, with a firm reliance on the protection of Divine Providence, we mutually pledge to each other our cooperation in achieving our common interests in maximum wellness, maximum longevity and health freedom.
LATEST HEADLINES FROM FIGHT AGING!
CONSIDERING MITOCHONDRIAL DYNAMICS IN THE CONTEXT OF AGING Friday, JulyÂ 6, 2012
A herd of mitochondria exists in every cell, producing the ATP necessary to power that cell. Damage to mitochondria is important in aging, but how damage progresses in a cell's mitochondrial population is complicated by the fact that these are not completely discrete and static entities.
They multiply like bacteria (fission), can merge with one another (fusion), and can also exchange individual components of their molecular machinery - so damage can be both passed around or mitigated depending on circumstances.
STEM CELL TRANSPLANT EXPLORED AS ALZHEIMER'S DISEASE THERAPY Friday, JulyÂ 6, 2012
Work on stem cell transplants in rats is outlined here: "Alzheimer's disease (AD) has been called the disease of the century with significant clinical and socioeconomic impacts. Epidemiological studies point out that AD affects 5% of the population over 65, and, parallel with increasing lifespan, the incidence of disease will rise dramatically.
NITRIC OXIDE AND AGING BLOOD VESSELS Thursday, JulyÂ 5, 2012
Nitric oxide levels are a possible target for therapies aimed at some of the signs of aging in blood vessels: "Many disorders emerge with advancing aging, and cardiovascular diseases (CVD) are a major cause of morbidity and mortality in the elderly.
The term vascular aging encompasses all the structural and functional alterations in the blood vessels with progressive aging. Both smooth muscle cells and intima layers are affected. These vascular changes lead to¦
SUGGESTING A TEST OF RAPAMYCIN AND METFORMIN TOGETHER Thursday, JulyÂ 5, 2012 Rapamycin extends life in mice through mechanisms similar to those of calorie restriction, but has serious side-effects - though researchers are working to separate the positive mechanisms from the undesirable negative mechanisms.
Metformin is also thought to be a calorie restriction mimetic drug, but the evidence for it to extend life in mice is mixed. Here, researchers suggest trying both drugs at the same time in the hopes that metformin blunts some of the side-effects of rapamycin:
CALORIE RESTRICTION BOOSTS STEM CELL FUNCTION Wednesday, JulyÂ 4, 2012
It is known that calorie restriction increases stem cell capacity in aging, thereby helping to maintain tissues for longer. From Extreme Longevity, a recent commentary on the mechanisms involved: "Like it or not food lovers, the single most effective known means of extending animal lifespan is through reducing daily caloric intake.
DISCUSSING IGF-1 AND HEART HEALTH IN MAMMALS Wednesday, JulyÂ 4, 2012
An open access commentary: "The mammalian heart must maintain its structural and functional integrity for decades, yet the response to damage in this vital organ is remarkably inadequate and often results in heart failure.
Moreover, patients with chronic heart failure show profound metabolic changes, leading to peripheral abnormalities in addition to an initial cardiac impairment. Several evidences have suggested a relationship between the IGF-1 system and cardiovascular disease.
ON OSTEOARTHRITIS Tuesday, JulyÂ 3, 2012
This open access review paper discusses what is known of osteoarthritis: "Half of all persons aged over 65 suffer from osteoarthritis (OA). As a matter of fact, age is the most prominent risk factor for the initiation and progression of OA. The common explanation for this is the cumulative effect of mechanical load over the years, resulting clinically in 'wear and tear' and pathologically in cartilagepathogenesis and progression of OA.
AKH, PHYSICAL ACTIVITY, AND CALORIE RESTRICTION BENEFITS Tuesday, JulyÂ 3, 2012 We know that autophagy seems to be required for calorie restriction to provide benefits to health and longevity, and here researchers argue that exercise is also required:
A DIFFERENT ARGUMENT FOR THE AGE-DEPENDENCE OF CANCER Monday, JulyÂ 2, 2012
The general view of cancer is that it occurs in the old because it depends on nuclear DNA mutations that accumulate over time - the more mutations, the greater the chance of one of them being suitable to trigger a cancer.
Here a researcher argues that it has less to do with the number of mutations and more to do with the changing (and more damaged) state of tissue and systems in the body, which increases the ability of mutated cells to survive and prosper:
ANOTHER APPROACH TO CREATING BLOOD VESSELS IN ENGINEERED TISSUE Monday, JulyÂ 2, 2012
Many research groups are working on ways to overcome the challenge of generating suitable blood vessel networks for engineered tissue, as this is one of the major blocking issues in generating large tissue masses from scratch: "Researchers are hopeful that new advances in tissue engineering and regenerative medicine could one day make a replacement liver from a patient's own cells, or animal muscle tissue that could be cut into steaks without ever being inside a cow.