Longevity News

Too Busy to Think?

posted on July 20, 2010

Are you like me? More often than not, I get too busy to think.

I’m painfully aware that an hour of effective thinking is worth a month of hard work, are you? Then why is it most of us don’t spend enough productive time thinking? Is it because we just get too busy? I have concluded that the answer is “Yes”.

That’s a pity. And inexcusable. I know better, and so do you. So why do we persist? Routines might be one answer. Routines suppress thinking. We get stuck in comfortable remote control modes. Interruptions are another answer. How many times a day do you instantly react to someone or something that interrupts your schedule? If you think about it, these are moving parades of stress creating events. Imagine how much easier and less stressful the rest of our lives would be if we took time out for regular, private focused thinking.

Most of us don’t though, and entire industries are build around this human weakness. Consultants abound to think for us. Let’s take a look at estate planning.

We typically spend more time planning our death than planning our lives. That’s because planners do it for us. There are big profits here. They call themselves financial planners, retirement planners, estate planners or life insurance salespersons. They get our attention by pointing out the big benefits to us from their planning. Our estate taxes are reduced, our assets don’t get tied up in probate, our loved ones get taken care of, our favorite charities benefit, and our businesses are protected.

But how about us? The success of all this thinking and planning depends on our dying. Well that sucks.

In all fairness, many of these planners perform good services. I just want to obsolete them, that’s all. Most of them are clever and resourceful, and they can find other lines of work as society evolves. And evolve we will. I see a whole new industry springing up that plans for our longevity enhanced lives. Wouldn’t it be more rewarding to help someone plan their long life than their death?

Now let’s get back to thinking. Thinking takes work. But it also saves a lot more work. Try this for one month:

Set aside a half hour a day, or at least two to three times a week, to sit in a quiet spot where no one and no thing will disturb you. Shut off your phone and email. Close your door, and give instructions to everyone in your household or office to not disturb you except for extreme emergencies. Better yet, find a quiet peaceful place away from your home or office.

Take a tablet and a pen, and write your most pressing challenge or your biggest goal at the top of the paper. Then open your mind to any and every possible idea, solution or plan you can think of. There are no bad ideas. Write them out as fast as you can think. About the time you think you have exhausted your ideas, you will come up with your best solutions. That’s because we usually write down the obvious at first, a lazy way of thinking. So stretch a little.

How about taking some time to plan what you want to do in fifty years or longer? When you get into this mindset, you’ll tend to start laying out steps to help ensure you live fifty more years. These steps could include your changes in your diet, fitness program and more.

Now here’s a critical key: After you finish your mindstorming, review your list carefully. Isolate your best ideas and immediately ACT on them. This is the step that makes your hour of thinking worth a month of hard work.

I was interviewed again on Superhuman Radio last week. You may want to tune in to:

http://www.superhumanradio.com/components/com_podcast/media/mp3s/SHR_Show_540.mp3

If you’d like to hear a previous interview, here’s a link:

http://www.superhumanradio.com/components/com_podcast/media/mp3s/SHR_Show_506.mp3

Long Life,
David Kekich
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ANNOUNCEMENTS

IMMORTALITY INSTITUTE INTERNATIONAL CONFERENCE IN OCTOBER

The Immortality Institute volunteers have put together a great line-up of speakers for their forthcoming conference in Brussels, Belgium on October 9th, including researchers Leonid Gavrilov, Michael Rose, Aubrey de Grey (of course), some of the Russians from the Science Against Aging initiative, and a range of others:

http://www.fightaging.org/archives/2010/07/immortality-institute-international-conference-october-2010-in-brussels.php

LIFESTAR INSTITUTE LAUNCHES NEW WEBSITE

The LifeStar Institute is a project of the Millard Foundation, a family organization whose principals decided a few years ago to throw their weight behind making rejuvenation medicine a reality.

http://www.fightaging.org/archives/2010/07/lifestar-institute-launches-new-website.php

"The Institute volunteers recently launched a new website to coincide with their call for global collaboration in longevity science. Leaders in the biology and polices of aging research at the first LifeStar Institute Global Aging Science Summit conclude the time has come to launch an ambitious global effort to keep aging generations youthful, productive, and engaged to unprecedented ages. In laboratories all over the world, using genome sciences, diets including calorie restriction, and techniques of cell science and regenerative medicine, scientists are now keeping living organisms alive and healthy for increasing lengths of time never before thought possible. The obvious question: When will medical science do the same for us?"
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LATEST HEALTHY LIFE EXTENSION HEADLINES

THE CASE FOR LATE-LIFE INTERVENTIONS IN AGING (July 16 2010) http://www.longevitymeme.org/news/vnl.cfm?id=4815
A position paper by Aubrey de Grey, a number of other important biogerontologists, and folk from the LifeStar Institute: "The social and medical costs of the biological aging process are high and will rise rapidly in coming decades, creating an enormous challenge to societies worldwide. In recent decades, researchers have expanded their understanding of the underlying deleterious structural and physiological changes (aging
damage) that underlie the progressive functional impairments, declining health, and rising mortality of aging humans and other organisms and have been able to intervene in the process in model organisms, even late in life. To preempt a global aging crisis, we advocate an ambitious global initiative to translate these findings into interventions for aging humans, using three complementary approaches to retard, arrest, and even reverse aging damage, extending and even restoring the period of youthful health and functionality of older people." This more or less reflects the LifeStar Institute position, complementary with that of the SENS Foundation, but with more of an organizational focus.

A CONSERVATIVE VIEW OF LONGEVITY SCIENCE (July 15 2010) http://www.longevitymeme.org/news/vnl.cfm?id=4813
This opinion piece is an example of the sort of viewpoint held by those who believe that metabolic manipulation to modestly slow aging is the only viable way forward in longevity science: "When I tell people that anti-aging drugs are no longer a distant prospect, they often assume I'm talking about the quest for immortality. That's not surprising, given the buzz generated in recent years by visionaries who speculate about re-engineering the human body to last thousands of years. But actually I don't find that far-out prospect very interesting - it bears the same relationship to serious aging science that warp-drive spaceships do to aeronautical engineering. What really grabs me are experimental advances that may impinge on the lives of people I know, maybe even mine. The only practical, near-term way to substantially increase healthy life span today is to simultaneously lower the risk of all diseases of aging. The way we now mainly buy time - administering therapies for one progressive, old-age disease at a time when it's too late to do much good - can't do that. Anti-aging drugs could, and at the same time they would go a long way toward ending the ruinously costly game of diminishing returns we're playing in geriatric medicine, as we eke out incremental gains with ever pricier palliatives. In effect, they would be preventive medicines of unprecedented scope and efficacy, drastically lowering the risk of everything from Alzheimer's to osteoporosis to wrinkles in the way that hypertension drugs now cut heart-attack risk."

URGING A GLOBAL COLLABORATION AGAINST AGING (July 15 2010) http://www.longevitymeme.org/news/vnl.cfm?id=4812
From the LifeStar Institute: "Leaders in the biology and polices of aging research at the first LifeStar Institute Global Aging Science Summit conclude the time has come to launch an ambitious global effort to keep aging generations youthful, productive, and engaged to unprecedented ages. In laboratories all over the world, using genome sciences, diets including calorie restriction, and techniques of cell science and regenerative medicine, scientists are now keeping living organisms alive and healthy for increasing lengths of time never before thought possible. The obvious question: When will medical science do the same for us? The scientific panel proposes that the United States and nations across the world create a global collaboration and launch an Apollo-like Project with the following goal: translate laboratory knowledge about the degenerative changes of aging into new kinds of medicines for humans that can prevent and repair those changes. The panel urges governments and the biomedical industry to fund three key initiatives: (1) Use public health agencies to inform citizens on how they can improve their lifestyles. (2) Develop the first genuine anti-aging medicines that are able to boost the body's ability to maintain health (3) Develop and apply regenerative methods that can remove, replace, repair, and neutralize the cellular and molecular damage that accumulate in aging bodies and restore youthful structure and function."

USING STEM CELLS TO BUILD TEST PLATFORMS (July 14 2010) http://www.longevitymeme.org/news/vnl.cfm?id=4811
Here is an example of the other use for stem cells: to grow tissue that can be used to test and understand specific diseases. "Researchers are applying new stem cell technology to use skin samples to grow the brain cells thought to be responsible for the onset of Parkinson's disease. [the] team will be gathering data from over 1,000 patients with early stage Parkinson's disease and taking small samples of skin tissue to grow special stem cells - induced pluripotent stem cells (iPS cells). iPS cells can be generated from accessible tissue such as the skin and then used to generate specific types of cell. The researchers will use the iPS cells to grow dopamine neurons - the brain cells responsible for the production of dopamine, as it is these cells which die in patients with Parkinson's, leading to the onset of the disease.  iPS cells provide new and exciting opportunities to grow and study dopamine neurons from patients for the first time. This technology will prove to be extremely important in diseases which affect the brain because of its relative inaccessibility - it's far easier to get a skin sample than a brain biopsy. Once we have neurons from patients we can compare the functioning of cells taken from patients with the disease and those without to better understand why dopamine neurons die in patients with Parkinson's."

LEF FUNDS GRANULOCYTE CANCER THERAPY (July 14 2010) http://www.longevitymeme.org/news/vnl.cfm?id=4810
A press release: "In a discovery that made headline news around the world, Dr. Zheng Cui, of the Wake Forest University School of Medicine, developed a colony of mice with super-charged granulocytes that successfully fight off many forms of virulent cancer.  In a surprising turn of events Dr. Cui also found that a similar cancer-killing activity is present in the granulocytes of some healthy humans.  When the Life Extension Foundation learned that this potential cancer cure was not being funded, it immediately made a $200,000 grant to fund the study at the South Florida Bone Marrow/Stem Cell Transplant Institute. This new clinical trial will test this approach in humans with advanced cancer, including metastases, who have not been helped by conventional cancer therapies. The trial has received an IND (investigational new drug) status from the Food and Drug Administration (FDA) and Institutional Review Board approval. In January of this year, Dr. Maharaj notified the Life Extension Foundation that progress was being slowed because expected funding sources had dried up. Life Extension responded with another grant of $600,000 to further advance what could be a cure for cancer."

THE GENETICS OF HORMESIS-INDUCED LONGEVITY (July 13 2010) http://www.longevitymeme.org/news/vnl.cfm?id=4809
Hormesis is the process whereby suffering a little biochemical damage switches metabolism into a high-repair, damage-resistant mode, thereby extending life. Here, researchers examine changes in gene expression associated with hormesis: "Ionizing radiation generates oxidative stress, which is thought to be a major cause of aging. Although living organisms are constantly exposed to low levels of radiation, most studies examining the effect of radiation have focused on accelerated aging and diminished life span that result from high-dose radiation. On the other hand, several studies have suggested that low-dose radiation enhances the longevity of Drosophila melanogaster. Therefore, investigation of the biological effects of low-dose radiation could contribute to a more comprehensive understanding of the aging process. In this study, microarray and quantitative real time-PCR were used to measure genome-wide changes in transcript levels in low-dose irradiated fruit flies that showed enhanced longevity. In response to radiation, approximately 13% of the genome exhibited changes in gene expression, and a number of aging-related genes were significantly regulated. These data were compared with quantitative trait loci affecting life-span to identify candidate genes involved in enhanced longevity induced by low-dose radiation. This genome-wide survey revealed novel information about changes in transcript levels in low-dose irradiated flies and identified 39 new candidate genes for molecular markers of extended longevity induced by ionizing radiation. In addition, this study also suggests a mechanism by which low-dose radiation extends longevity."

THE COST OF OBESITY (July 13 2010) http://www.longevitymeme.org/news/vnl.cfm?id=4808
A good example of what obesity does to your long term health: "Men who enter adult life obese face a life-long doubling of the risk of dying prematurely, new research has found. In a study presented today (Tuesday) at the International Congress on Obesity in Stockholm, researchers tracked more than 5,000 military conscripts starting at the age of 20 until up to the age of 80. They found that at any given age, an obese man was twice as likely to die as a man who was not obese and that obesity at age 20 years had a constant effect on death up to 60 years later. They also found that the chance of dying early increased by 10% for each BMI point above the threshold for a healthy weight and that this persisted throughout life, with the obese dying about eight years earlier than the non-obese. Body mass index (BMI) was measured at the average ages of 20, 35 and 46 years, and the researchers investigated that in relation to death in the next follow-up period. A total of 1,191 men had died during the follow-up period of up to 60 years. The results were adjusted to eliminate any influence on the findings from year of birth, education and smoking. At age 70 years, 70% of the men in the comparison group and 50% of those in the obese group were still alive and we estimated that from middle age, the obese were likely to die eight years earlier than those in the comparison group."

PTEN AND NERVE REGENERATION (July 12 2010) http://www.longevitymeme.org/news/vnl.cfm?id=4806

Via EurekAlert!: "Scientists have discovered a way to enhance nerve regeneration in the peripheral nervous system. This important discovery could lead to new treatments for nerve damage caused by diabetes or traumatic injuries. Peripheral nerves connect the brain and spinal cord to the body, and without them, there is no movement or sensation. Peripheral nerve damage is common and often irreversible. [Researchers] used a rat model to examine a pathway that helps nerves to grow and survive. Within this pathway is a molecular brake, called PTEN, that helps to prevent excessive cell growth under normal conditions. In addition to discovering for the first time that PTEN is found in the peripheral nervous system, [the team] demonstrated that following nerve injury, PTEN prevents peripheral nerves from regenerating. The team was able to block PTEN, an approach that dramatically increased nerve outgrowth. We were amazed to see such a dramatic effect over such a short time period. No one knew that nerves in the peripheral system could regenerate in this way, nerves that can be damaged if someone has diabetes for example. This finding could eventually help people who have lost feeling or motor skills recover and live with less pain."

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